Protein Overview: Ilp2-PA

General Information:
Name(s) found:	Ilp2-PA / FBpp0076058 [FlyBase]
Description(s) found: Found 26 descriptions. SHOW ALL	The gene Insulin-like peptide 2 is referred to in FlyBase by the symbol Dmel\Ilp2 (CG8167, FBgn0036046). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 3L:9792798..9793545. It has the cytological map location 67C8. Based on sequence similarity, it is predicted to have molecular function</span>: insulin receptor binding. There is experimental evidence that it is involved in the biological process</span>: insulin receptor signaling pathway; larval feeding behavior; regulation of multicellular organism growth; regulation of cell size; germ-line stem-cell niche homeostasis. 4 alleles are reported. No phenotypic data is available. It has one annotated transcript and one annotated polypeptide. [FlyBase]
Organism:	Drosophila melanogaster
Length:	137 amino acids
Gene Ontology:
Cellular Component:	extracellular region [ISS]
Biological Process:	larval feeding behavior [IMP] regulation of multicellular organism growth [IMP] insulin receptor signaling pathway [IGI][ISS][TAS] germ-line stem-cell niche homeostasis [IMP] regulation of cell size [IMP] growth [TAS] positive regulation of multicellular organism growth [TAS]
Molecular Function:	insulin receptor binding [ISS] hormone activity [IEA][NAS]

Sequence:
Sequence: [PDR BLAST] [ProtParam]	1 11 21 31 41 51 \| \| \| \| \| \| 1 MSKPLSFISM VAVILLASST VKLAQGTLCS EKLNEVLSMV CEEYNPVIPH KRAMPGADSD 60 61 LDALNPLQFV QEFEEEDNSI SEPLRSALFP GSYLGGVLNS LAEVRRRTRQ RQGIVERCCK 120 121 KSCDMKALRE YCSVVRN

Protein Complex Data

No complex found for this protein.

Mass Spectrometry Data

No mass spectrometry results found for this protein.

Yeast Two-Hybrid Data

The following interactions contain this protein:

SHOWING SINGLE HITS. [ Hide Single Hits ]

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No yeast two-hybrid interactions found for this protein.

Microscopy / Localization Data

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No microscopy data found in the PDR for this protein.

Protein Structure Data

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[View Top Sequence Alignments] [Show Ginzu Version Information]

Domains predicted:

#		Region(s)	Method	Confidence	Match Description
1	View Details	[1..137]	PSI-BLAST	15.0	THREE-DIMENSIONAL STRUCTURE OF HUMAN INSULIN-LIKE GROWTH FACTOR-I (IGF-I) DETERMINED BY 1H-NMR AND DISTANCE GEOMETRY, 6 STRUCTURES

Functions predicted (by domain):

#

Gene Ontology predictions

1

Term	Confidence	Notes
receptor binding	4.96234302646827	bayes_pls_golite062009
insulin-like growth factor receptor binding	4.48857896892351	bayes_pls_golite062009
growth factor activity	4.19304935106952	bayes_pls_golite062009
insulin receptor binding	3.85109459565499	bayes_pls_golite062009
binding	2.07081269731637	bayes_pls_golite062009
insulin-like growth factor binding	1.91342474664514	bayes_pls_golite062009
growth factor binding	1.84573028463276	bayes_pls_golite062009
protein binding	1.63714982602479	bayes_pls_golite062009
hormone activity	1.5588633384762	bayes_pls_golite062009
protein complex binding	1.3998769992239	bayes_pls_golite062009
protease binding	0.619038701508311	bayes_pls_golite062009

Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

Philius Transmembrane Prediction:

[View Details]

Source: Reynolds et al. 2008. Manuscript submitted

Philius confidence legend

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