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View Structure Prediction Details

Protein: Ilp2-PA
Organism: Drosophila melanogaster
Length: 137 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for Ilp2-PA.

Description E-value Query
Range		 Subject
Range
INS1_RAT - Insulin-1 OS=Rattus norvegicus GN=Ins1 PE=1 SV=1
 114.0 [0..1] [133..1]
INS_PONPY - Insulin OS=Pongo pygmaeus GN=INS PE=3 SV=1
 111.0 [0..1] [133..1]
INS - insulin
gi|22901140 - gi|22901140|gb|AAN06935.1| insulin precursor [Gorilla gorilla]
gi|123992113, gi... - gi|61361299|gb|AAX42026.1| insulin [synthetic construct], gi|61361296|gb|AAX42025.1| insulin [synthe...
INS_GORGO - Insulin OS=Gorilla gorilla gorilla GN=INS PE=3 SV=1
 111.0 [0..1] [133..1]
gi|30584395, gi|... - gi|60653575|gb|AAX29481.1| insulin [synthetic construct], gi|60653573|gb|AAX29480.1| insulin [synthe...
 110.0 [0..1] [133..1]
INS_CHLAE - Insulin OS=Chlorocebus aethiops GN=INS PE=1 SV=1
 110.0 [0..1] [133..1]
INS_CRILO - Insulin OS=Cricetulus longicaudatus GN=INS PE=1 SV=2
gi|305360, gi|21... - gi|305360|gb|AAA37089.1| preproinsulin, gi|2137094|pir||I48166 insulin precursor - golden hamster
 110.0 [0..1] [133..1]
INS_CHICK - Insulin OS=Gallus gallus GN=INS PE=1 SV=1
 110.0 [0..1] [133..1]
INS_MACFA - Insulin OS=Macaca fascicularis GN=INS PE=3 SV=1
 110.0 [0..1] [133..1]
INS_PANTR - Insulin OS=Pan troglodytes GN=INS PE=1 SV=1
 110.0 [0..1] [133..1]

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Predicted Domain #1
Region A:
Residues: [1-137] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSKPLSFISM VAVILLASST VKLAQGTLCS EKLNEVLSMV CEEYNPVIPH KRAMPGADSD  60
   61 LDALNPLQFV QEFEEEDNSI SEPLRSALFP GSYLGGVLNS LAEVRRRTRQ RQGIVERCCK 120
  121 KSCDMKALRE YCSVVRN

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 15.0
Match: 1bqtA
Description: THREE-DIMENSIONAL STRUCTURE OF HUMAN INSULIN-LIKE GROWTH FACTOR-I (IGF-I) DETERMINED BY 1H-NMR AND DISTANCE GEOMETRY, 6 STRUCTURES
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
receptor binding 4.96234302646827 bayes_pls_golite062009
insulin-like growth factor receptor binding 4.48857896892351 bayes_pls_golite062009
growth factor activity 4.19304935106952 bayes_pls_golite062009
insulin receptor binding 3.85109459565499 bayes_pls_golite062009
binding 2.07081269731637 bayes_pls_golite062009
insulin-like growth factor binding 1.91342474664514 bayes_pls_golite062009
growth factor binding 1.84573028463276 bayes_pls_golite062009
protein binding 1.63714982602479 bayes_pls_golite062009
hormone activity 1.5588633384762 bayes_pls_golite062009
protein complex binding 1.3998769992239 bayes_pls_golite062009
protease binding 0.619038701508311 bayes_pls_golite062009
YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle