Protein Overview: Gug-PA

General Information:
Name(s) found:	Gug-PA / FBpp0076343 [FlyBase]
Description(s) found: SHOW ONLY BEST	gi\|24660946\|ref\|NP_659574.1\| grunge, isoform A [Drosophila melanogaster] [NCBI NR] gi\|23093912\|gb\|AAN12008.1\| grunge, isoform A [Drosophila melanogaster] [NCBI NR] The gene Grunge is referred to in FlyBase by the symbol Dmel\Gug (CG6964, FBgn0010825). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 3L:8443416..8465769. It has the cytological map location 66C13-66D1. There is experimental evidence that it has the molecular function</span>: histone deacetylase activity; transcription repressor binding; transcription corepressor activity; DNA binding. There is experimental evidence that it is involved in the biological process</span>: eye development; segment specification; negative regulation of transcription; negative regulation of epidermal growth factor receptor signaling pathway; embryonic pattern specification; segmentation; imaginal disc-derived wing vein morphogenesis; imaginal disc-derived leg morphogenesis. 38 alleles are reported. The phenotypes of these alleles are annotated with: leg; embryonic head; interommatidial bristle; embryonic segment; tarsal segment; wing; larval brain; ommatidium; wing vein. It has 4 annotated transcripts and 4 annotated polypeptides. [FlyBase] >CG6964-PA translation from_gene[CG6964 Gug FBgn0010825] seq_release:3 mol_weight=208169 cds_boundaries:(3L:8,420,751..8,429,477[+]) aa_length:1966 transcript_info:[CG6964-RA seq_release:3] gene_info:[gene symbol:Gug FBgn0010825 gene_boundaries:(3L:8,4 [hmr_yeast5_DM3-1_pombe.fasta] (Q8IQA6) CG6964-PA [DrosMelano7227.FASTAC.txt] CG6964-PA, isoform A [Drosophila melanogaster]gi\|24660946\|ref\|NP_659574.1\| CG6964-PA [Drosophila melanogaster] [nrdb_11152004_Chlamydomonas] type=protein; loc=3L:join(8455141..8455203,8456104..8456337,8456401..8461174,8461235..8461358,8461439..8461583,8461644..8461804,8462510..8462593,8462665..8462791,8463254..8463287,8463385..8463479,8463540..8463583,8463855..8463870); ID=FBpp0076343; name=Gu [fly-100309-contam.fasta] CG6964-PA, isoform A [Drosophila melanogaster] [nr-271106-contam.fasta] Grunge CG6964-PA, isoform A [Drosophila melanogaster] [nr-271106-contam.fasta] type=protein; loc=3L:join(8455141..8455203,8456104..8456337,8456401..8461174,8461235..8461358,8461439..8461583,8461644..8461804,8462510..8462593,8462665..8462791,8463254..8463287,8463385..8463479,8463540..8463583,8463855..8463870); ID=FBpp0076343; name=Gug-PA; parent=FBgn0010825,FBtr0076616; dbxref=FlyBase:FBpp0076343,FlyBase_Annotation_IDs:CG6964-PA,GB_protein:AAN12008.1,REFSEQ:NP_659574,GB_protein:AAN12008; MD5=0f60d95340905402035ecdfbf8386545; length=1966; release=r5.16; species=Dmel; [fly-contam-His-TEV-Tub4complex.fasta] type=protein; loc=3L:join(8455141..8455203,8456104..8456337,8456401..8461174,8461235..8461358,8461439..8461583,8461644..8461804,8462510..8462593,8462665..8462791,8463254..8463287,8463385..8463479,8463540..8463583,8463855..8463870); ID=FBpp0076343; name=Gug-PA; parent=FBgn0010825,FBtr0076616; dbxref=FlyBase:FBpp0076343,FlyBase_Annotation_IDs:CG6964-PA,GB_protein:AAN12008.1,REFSEQ:NP_659574,GB_protein:AAN12008; MD5=0f60d95340905402035ecdfbf8386545; length=1966; release=r5.21; species=Dmel; [Other_drosophila_na_09-09-2009_reversed.fasta] Grunge, isoform A OS=Drosophila melanogaster GN=Gug PE=2 SV=1 [UniProt_drosophila_07-01-2011_reversed.fasta] type=protein; loc=3L:join(8455141..8455203,8456104..8456337,8456401..8461174,8461235..8461358,8461439..8461583,8461644..8461804,8462510..8462593,8462665..8462791,8463254..8463287,8463385..8463479,8463540..8463583,8463855..8463870); ID=FBpp0076343; name=Gug-PA; parent=FBgn0010825,FBtr0076616; dbxref=FlyBase:FBpp0076343,FlyBase_Annotation_IDs:CG6964-PA,GB_protein:AAN12008.1,REFSEQ:NP_659574,GB_protein:AAN12008,FlyMine:FBpp0076343,modMine:FBpp0076343; MD5=0f60d95340905402035ecdfbf8386545; length=1966; release=r5.46; species=Dmel; [fly-062812-sfps-sandra-contam.fasta] type=protein; loc=3L:join(8462041..8462103,8463004..8463237,8463301..8468074,8468135..8468258,8468339..8468483,8468544..8468704,8469410..8469493,8469565..8469691,8470154..8470187,8470285..8470379,8470440..8470483,8470755..8470770); ID=FBpp0076343; name=Gug-PA; parent=FBgn0010825,FBtr0076616; dbxref=FlyBase:FBpp0076343,FlyBase_Annotation_IDs:CG6964-PA,GB_protein:AAN12008.1,REFSEQ:NP_659574,GB_protein:AAN12008,FlyMine:FBpp0076343,modMine:FBpp0076343; MD5=0f60d95340905402035ecdfbf8386545; length=1966; release=r6.02; species=Dmel; [fly-2014-05-contam.fasta] type=protein; loc=3L:join(8462041..8462103,8463004..8463237,8463301..8468074,8468135..8468258,8468339..8468483,8468544..8468704,8469410..8469493,8469565..8469691,8470154..8470187,8470285..8470379,8470440..8470483,8470755..8470770); ID=FBpp0076343; name=Gug-PA; parent=FBgn0010825,FBtr0076616; dbxref=FlyBase:FBpp0076343,FlyBase_Annotation_IDs:CG6964-PA,GB_protein:AAN12008.1,REFSEQ:NP_659574,GB_protein:AAN12008,FlyMine:FBpp0076343,modMine:FBpp0076343; MD5=0f60d95340905402035ecdfbf8386545; length=1966; release=r6.07; species=Dmel; [fly-08202015-contam.fasta] Isoform of M9PHT1, Grunge, isoform A OS=Drosophila melanogaster GN=Gug PE=1 SV=1 [DROME.fasta.20160308] FBpp0076343 type=protein; loc=3L:join(8462041..8462103,8463004..8463237,8463301..8468074,8468135..8468258,8468339..8468483,8468544..8468704,8469410..8469493,8469565..8469691,8470154..8470187,8470285..8470379,8470440..8470483,8470755..8470770); ID=FBpp0076343; name=Gug-PA; parent=FBgn0010825,FBtr0076616; dbxref=FlyBase:FBpp0076343,FlyBase_Annotation_IDs:CG6964-PA,GB_protein:AAN12008.1,REFSEQ:NP_659574,GB_protein:AAN12008,FlyMine:FBpp0076343,modMine:FBpp0076343; MD5=0f60d95340905402035ecdfbf8386545; length=1966; release=r6.09; species=Dmel; [dmel-all-translation-r6.09.fasta] [fly-122215-dmel-6-09-contam.fasta] type=protein; loc=3L:join(8462041..8462103,8463004..8463237,8463301..8468074,8468135..8468258,8468339..8468483,8468544..8468704,8469410..8469493,8469565..8469691,8470154..8470187,8470285..8470379,8470440..8470483,8470755..8470770); ID=FBpp0076343; name=Gug-PA; parent=FBgn0010825,FBtr0076616; dbxref=FlyBase:FBpp0076343,FlyBase_Annotation_IDs:CG6964-PA,GB_protein:AAN12008.1,REFSEQ:NP_659574,GB_protein:AAN12008,UniProt/TrEMBL:Q8IQA6,FlyMine:FBpp0076343,modMine:FBpp0076343; MD5=0f60d95340905402035ecdfbf8386545; length=1966; release=r6.14; species=Dmel; [fly-dmel-jan2017-sandracontam.fasta]
Organism:	Drosophila melanogaster
Length:	1966 amino acids
Gene Ontology:
Cellular Component:	nucleus [IDA]
Biological Process:	imaginal disc-derived leg morphogenesis [IMP] eye development [IMP] segmentation [IMP] negative regulation of transcription [IDA] embryonic pattern specification [IMP] imaginal disc-derived wing vein morphogenesis [IMP] negative regulation of epidermal growth factor receptor signaling pathway [IGI] segment specification [IMP]
Molecular Function:	DNA binding [IDA] transcription repressor binding [IPI] histone deacetylase activity [IDA] transcription corepressor activity [IDA][IGI][NAS]

Sequence:

Sequence:
[PDR BLAST]
[ProtParam]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MAASTQGEIR VGPGHQVNDV YAKLPDYNPI SSFPIDKETD ERELEESRWS PGVVADGDLL  60
   61 MFLRAARSMA AFQGMCDGGL EDGCLAASRD DTTINALDVL HDSGYDPGKA LQALVKCPVS 120
  121 KGIDKKWTED ETKKFIKGLR QFGKNFFRIH KDLLPHKDTP ELVEFYYLWK KTPGANNNRP 180
  181 HRRRRQSALR RNRVTRANNS NSNTPPKKED TPEPQTATTA TAAATAASET ASRSSPAVSK 240
  241 EENSSLTEDD ASECDSDSSL THKRDESPSR MRTRNKQQNN NSSTSSGNNT AGNGGGNATS 300
  301 ISSGSTGGGA AGGNSSSKDQ SANAVANGKR PKRGSETPDV SGGASVDSPK TPTKAVAESS 360
  361 ANKRKGGKQD TPNKKKRTEQ ESNEPSAHEE NAIKEKRKRP DSPVESMNSD SRPDSVLDDG 420
  421 ESNTTDTTTA EQQSTKDSKE TVSCKEEREM VTNDLEAKAE EKAIKAEALA EDSKDSAIKN 480
  481 MDEETNIQAP SSADTSLVDG PNPNALPSPV AAPITMKVPT IATVEALNAS VDRKEAIEKM 540
  541 ESCDSDPEML KKLATIKQEV SPQQQQHMQQ QSQQQMQQQL APVGIPQPPS CPPSESVYIK 600
  601 KEPMEDSMDA TCNQNSNEPQ DLKVKIEIKN EDALKHSAGG LPPSGPCAPP SALHPLSGAP 660
  661 VESGQEPLHL QHMPHGQVTT QPPPGYLIDG QLKYGPSGQG VPPQPPQLHS DAAGGVSGAP 720
  721 PGAPTTPQKY PPEMEMKFAP QDLKYPPPPP LDALKYSQEM QAAAAAAAAA GKYDMKYMME 780
  781 QQGKYNVELS AAHQPPSKPG YQDSLKIPDI KPGFGHLPHN VGSPLDAAHK YGPPPTSQES 840
  841 QQQQPQPPAH QVPPGATPPP GIAMPKPHYQ HDVQTPPLGR PFEPTGLMLK YGDPLAAKYG 900
  901 PPQDLKYPMP PVSQAGPADV KPYGGENLIK SSPYGPPPES PIDASARSTP GQDSQGSNSN 960
  961 SQPPSMPPQP QQFQSPHPSP HMPSPAGGGL PPGMHPQNLI HGPPPGAAGG SGPQPPPPPT1020
 1021 SLHQPTPTSA GPPSLQHGLH PGHQHSQLSV ASSIPPSSIG IPPTLSTMAP SHMHPHLHPH1080
 1081 AHLQGLHRPH DLPPSMHPHA PMPLSLQGHP QHGHGLPPSH TSQQQQQQQQ QQQPGGPAGT1140
 1141 VRTPSPAQQP PRSMHDPQSS REPPTSQPST TMAGSSGPGG PPPQQSPHAH RTSPLPGLAG1200
 1201 SGPPPPGLIG HPMAIHPHLA HLPPGHPAHA ALAHPGHHLL SHSIAGLGPG GGPIALLAGP1260
 1261 GGLGGIPESA LSRRTPPSHL PHSHASSAPL TAHSVASMTS TSMSLTTSTV PSSAFSRASP1320
 1321 SVQISSSGGG PSGPGSVGPG GMPNSSAAAA AAAAAHRAAS PASSVSSLSR QSPLHPVPQS1380
 1381 PLSHHPSSSA LSAAAAAVAE RDRHALMRQQ SPHMTPPPVS NASLMASPLS KMYAPQPGQR1440
 1441 GLGTSPPPHL RPGASPPVIR HPQMPLPLPL IAPGGGIPQI GVHPGQSPYP HPLLHPSVFY1500
 1501 SPHHHPFNSP YGYAPYGPGF PAYMKPPPQP GQLDPAAVMA AHHAGLQGPP PQQMRQDEQN1560
 1561 AAAAAAQAAA EKQHQAAAAA AAQQHKAPQQ QQPGGMPPNK PPTPKTPQGP GGGMPPGMGG1620
 1621 PGTPTGLPPG AYPGSHMPGY PQGPPHGSPF APQDGQPHGL KPTSHMDALR AHAHSANSAG1680
 1681 MGGGHHPTEP LPIDIEPDPE PEIPSPTHNI PRGPSPEAKP DDTECHRSQS AIFVRHIDRG1740
 1741 DYNSCTRTDL IFKPVADSKL ARKREERDRK LAEKERERRQ QQQQQQQQQQ QQQAAAAQQA1800
 1801 AQQAKMKAEL KPPYADTPAL RQLSEYARPH VAFRELEEIK NAQAAAASQS RLDPHWMEYY1860
 1861 RRGIHPSQFP LYANPAISQM ERERLGIPPP HHVGLDPGEH MVRMPQPPEA GFQLPPNVGQ1920
 1921 YPRPNMLIPR EPHSDVLLRM SYADQLQAAE FQRQSLHDQY FRQRPR

Protein Complex Data

No complex found for this protein.

Mass Spectrometry Data

No mass spectrometry results found for this protein.

Yeast Two-Hybrid Data

The following interactions contain this protein:

NOT SHOWING SINGLE HITS. [ Show Single Hits ]

[View our yeast two-hybrid interpretation guidelines.]

No yeast two-hybrid interactions found for this protein.

Protein predicted to be:	GLOBULAR (No transmembrane regions or signal peptide)
Confidence of classification:	0.83

Protein Overview: Gug-PA

Protein Complex Data

Mass Spectrometry Data

Yeast Two-Hybrid Data

Microscopy / Localization Data

Protein Structure Data

Philius Transmembrane Prediction: