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Protein Overview: MED4-PA

General Information:
Name(s) found: MED4-PA / FBpp0076599 [FlyBase]
Description(s) found:
Found 22 descriptions.
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  • The gene Mediator complex subunit 4 is referred to in FlyBase by the symbol Dmel\MED4 (CG8609, FBgn0035754). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 3L:7242629..7243623. It has the cytological map location 65E9. There is experimental evidence that it has the molecular function</span>: protein binding; RNA polymerase II transcription mediator activity; transcription coactivator activity. There is experimental evidence that it is involved in the biological process</span>: dendrite morphogenesis; muscle organ development; regulation of transcription from RNA polymerase II promoter; transcription from RNA polymerase II promoter. 4 alleles are reported. No phenotypic data is available. It has one annotated transcript and one annotated polypeptide. [FlyBase]
    • Organism: Drosophila melanogaster
    Length: 258 amino acids

    Gene Ontology:
    Cellular Component: mediator complex [IDA][ISS]
    Biological Process: muscle organ development [IMP]
    transcription from RNA polymerase II promoter [IMP]
    transcription initiation from RNA polymerase II promoter [ISS]
    regulation of transcription from RNA polymerase II promoter [IDA]
    dendrite morphogenesis [IMP]
    Molecular Function: protein binding [IPI]
    transcription coactivator activity [IDA]
    RNA polymerase II transcription mediator activity [IMP][ISS]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSFHLSTKER LLLLIDDIEM IAKELIEQAH QKISSTELVD LLDLLVAKDE EFRKMLELAE  60
   61 EQAKVEEAMD QLRAKVEVHD REIQKLQKSL KDAELILSTA IFQARQKLAS INQANKRPVS 120
  121 SEELIKYAHR ISSANAVSAP LTWCIGDLRR PYPTDIEMRN GLLGKSEQNI NGGTVTHQNS 180
  181 GMPSEQQRTL SGSAGSGSGS GAGGEVPNAF QNQFNWNLGE LHMTMGASGN TVALETRAQD 240
  241 DVEVMSTDSS SSSSSDSQ

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    SHOWING SINGLE HITS. [ Hide Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


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    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..189] FFAS03 1.4 No description for 2i1jA was found.
    2 View Details [190..258] deduced N/A No confident structure predictions are available.


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle