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Protein Overview: Pole2-PA

General Information:
Name(s) found: Pole2-PA / FBpp0076789 [FlyBase]
Description(s) found:
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  • gi|7295418|gb|AAF50735.1| Pole2 [Drosophila melanogaster] [NCBI NR]
  • gi|24658786|ref|NP_647995.1| Pole2 [Drosophila melanogaster] [NCBI NR]
  • The gene Pole2 is referred to in FlyBase by the symbol Dmel\Pole2 (CG10489, FBgn0035644). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 3L:5888785..5890479. It has the cytological map location 64F4. Based on sequence similarity, it is predicted to have molecular function</span>: DNA-directed DNA polymerase activity. There is experimental evidence that it is involved in the biological process</span>: cellular response to DNA damage stimulus. 2 alleles are reported. No phenotypic data is available. It has one annotated transcript and one annotated polypeptide. [FlyBase]
  • >CG10489-PA translation from_gene[CG10489 CG10489 FBgn0035644] seq_release:3 mol_weight=58759 cds_boundaries:(3L:5,855,056..5,856,687[-]) aa_length:525 transcript_info:[CG10489-RA seq_release:3] gene_info:[gene symbol:CG10489 FBgn0035644 gene_boundarie [hmr_yeast5_DM3-1_pombe.fasta]
  • (Q9VRQ7) CG10489 protein [DrosMelano7227.FASTAC.txt]
  • (AE003564) CG10489 gene product [Drosophila melanogaster] [yeastflysequest.fasta]
  • CG10489-PA [Drosophila melanogaster]gi|24658786|ref|NP_647995.1| CG10489-PA [Drosophila melanogaster] [nrdb_11152004_Chlamydomonas]
  • type=protein; loc=3L:complement(5888845..5889716,5889774..5890479); ID=FBpp0076789; name=Pole2-PA; parent=FBgn0035644,FBtr0077081; dbxref=FlyBase:FBpp0076789,FlyBase_Annotation_IDs:CG10489-PA,GB_protein:AAF50735.1,REFSEQ:NP_647995,GB_protein:AAF50735; MD5 [fly-100309-contam.fasta]
  • CG10489-PA [Drosophila melanogaster] [nr-271106-contam.fasta]
  • Pole2 CG10489-PA [Drosophila melanogaster] [nr-271106-contam.fasta]
  • type=protein; loc=3L:complement(5888845..5889716,5889774..5890479); ID=FBpp0076789; name=Pole2-PA; parent=FBgn0035644,FBtr0077081; dbxref=FlyBase:FBpp0076789,FlyBase_Annotation_IDs:CG10489-PA,GB_protein:AAF50735.1,REFSEQ:NP_647995,GB_protein:AAF50735; MD5=584b58b698932a5ac2bf90808c9fbbb5; length=525; release=r5.16; species=Dmel; [fly-contam-His-TEV-Tub4complex.fasta]
  • type=protein; loc=3L:complement(5888845..5889716,5889774..5890479); ID=FBpp0076789; name=Pole2-PA; parent=FBgn0035644,FBtr0077081; dbxref=FlyBase:FBpp0076789,FlyBase_Annotation_IDs:CG10489-PA,GB_protein:AAF50735.1,REFSEQ:NP_647995,GB_protein:AAF50735; MD5=584b58b698932a5ac2bf90808c9fbbb5; length=525; release=r5.21; species=Dmel; [Other_drosophila_na_09-09-2009_reversed.fasta]
  • Pole2 OS=Drosophila melanogaster GN=Pole2 PE=1 SV=1 [UniProt_drosophila_07-01-2011_reversed.fasta]
  • type=protein; loc=3L:complement(5888845..5889716,5889774..5890479); ID=FBpp0076789; name=Pole2-PA; parent=FBgn0035644,FBtr0077081; dbxref=FlyBase:FBpp0076789,FlyBase_Annotation_IDs:CG10489-PA,GB_protein:AAF50735.1,REFSEQ:NP_647995,GB_protein:AAF50735,FlyMine:FBpp0076789,modMine:FBpp0076789; MD5=584b58b698932a5ac2bf90808c9fbbb5; length=525; release=r5.46; species=Dmel; [fly-062812-sfps-sandra-contam.fasta]
  • Pole2 OS=Drosophila melanogaster GN=Pole2 PE=2 SV=1 [UniProt_D_Melanogaster_07132012_07-13-2012_reversed.fasta]
  • type=protein; loc=3L:complement(join(5896674..5897379,5895745..5896616)); ID=FBpp0076789; name=DNApol-epsilon58-PA; parent=FBgn0035644,FBtr0077081; dbxref=FlyBase:FBpp0076789,FlyBase_Annotation_IDs:CG10489-PA,GB_protein:AAF50735.1,REFSEQ:NP_647995,GB_protein:AAF50735,FlyMine:FBpp0076789,modMine:FBpp0076789; MD5=584b58b698932a5ac2bf90808c9fbbb5; length=525; release=r6.02; species=Dmel; [fly-2014-05-contam.fasta]
  • type=protein; loc=3L:complement(join(5896674..5897379,5895745..5896616)); ID=FBpp0076789; name=DNApol-epsilon58-PA; parent=FBgn0035644,FBtr0077081; dbxref=FlyBase:FBpp0076789,FlyBase_Annotation_IDs:CG10489-PA,GB_protein:AAF50735.1,REFSEQ:NP_647995,GB_protein:AAF50735,FlyMine:FBpp0076789,modMine:FBpp0076789; MD5=584b58b698932a5ac2bf90808c9fbbb5; length=525; release=r6.07; species=Dmel; [fly-08202015-contam.fasta]
  • DNA polymerase epsilon subunit 2 OS=Drosophila melanogaster GN=DNApol-epsilon58 PE=1 SV=1 [DROME.fasta.20160308]
  • FBpp0076789 type=protein; loc=3L:complement(join(5896674..5897379,5895745..5896616)); ID=FBpp0076789; name=DNApol-epsilon58-PA; parent=FBgn0035644,FBtr0077081; dbxref=FlyBase:FBpp0076789,FlyBase_Annotation_IDs:CG10489-PA,GB_protein:AAF50735.1,REFSEQ:NP_647995,GB_protein:AAF50735,FlyMine:FBpp0076789,modMine:FBpp0076789; MD5=584b58b698932a5ac2bf90808c9fbbb5; length=525; release=r6.09; species=Dmel; [dmel-all-translation-r6.09.fasta]
  • [fly-122215-dmel-6-09-contam.fasta]
  • type=protein; loc=3L:complement(join(5896674..5897379,5895745..5896616)); ID=FBpp0076789; name=DNApol-epsilon58-PA; parent=FBgn0035644,FBtr0077081; dbxref=FlyBase:FBpp0076789,FlyBase_Annotation_IDs:CG10489-PA,GB_protein:AAF50735.1,REFSEQ:NP_647995,GB_protein:AAF50735,UniProt/TrEMBL:Q9VRQ7,FlyMine:FBpp0076789,modMine:FBpp0076789; MD5=584b58b698932a5ac2bf90808c9fbbb5; length=525; release=r6.14; species=Dmel; [fly-dmel-jan2017-sandracontam.fasta]
    • Organism: Drosophila melanogaster
    Length: 525 amino acids

    Gene Ontology:
    Cellular Component: epsilon DNA polymerase complex [ISS][NAS]
    Biological Process: DNA replication [IEA]
    DNA-dependent DNA replication [IEA][NAS]
    response to DNA damage stimulus [IMP]
    Molecular Function: DNA binding [IEA]
    DNA-directed DNA polymerase activity [ISS]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MDVDLLPLRK RITNTFKLCG FLIRSENSSY LAEQLLPFDA AERDKWLTVI TENLQSQKLL  60
   61 TPHVERAALE KAINELNRVG LDEGETVFAL IDAFTVPRFR YNQRIKKFEL DTQPRQLLTA 120
  121 PRMKSDYMQQ RYAMLLQKTL RHDLFAPAVI QDGVGAEAQA KKFKLQFAEN LLATSAMKEA 180
  181 VVLGLLTQLK EGKFYVEDPT GCVQLDLTGA RFHAGFFCEG CFVLAEGNYN NGVLKVDGLG 240
  241 FPPAEPANSS RAFFGTANTW GGESAKLLKY SAGLQELERT NTETTIVFLS DVRLDLPVVM 300
  301 EKLRQLFVGY DSCPPQAIVL MGPFTASTRN HHELRHHLDA LGGLAAGCEQ LKKQTDLILV 360
  361 PSSEDPTAPN ILPRAPIPEC LAAGLLKAWP RTQLATNPCR LQYCTQQIVV CRLDLMAKFC 420
  421 RNTLHFPEDT SQIEQHFART IVCQGHLVPI HPIAMPVHWD YDPALWLYPL PDLIVMGDSC 480
  481 QSFSSSQHGC TVLNTGSFVK SKFAFKVYIP ATRTIEDSEI PDELE

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    SHOWING SINGLE HITS. [ Hide Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data



    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle