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Protein Overview: Dhc64C-PA

General Information:
Name(s) found: Dhc64C-PA / FBpp0073215 [FlyBase]
Description(s) found:
Found 20 descriptions.
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  • The gene Dynein heavy chain 64C is referred to in FlyBase by the symbol Dmel\Dhc64C (CG7507, FBgn0010349). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 3L:4807368..4825733. It has the cytological map location 64B17-64C1. There is experimental evidence that it has the molecular function</span>: microtubule motor activity; ATPase activity, coupled. There is experimental evidence for 24 unique biological process</span> terms, many of which group under: anatomical structure development; cell cycle; reproductive process in a multicellular organism; cell cycle process; cellular localization; transport; microtubule-based movement; organelle organization; regulation of cellular component organization; RNA localization. 49 alleles are reported. The phenotypes of these alleles are annotated with 23 unique terms, many of which group under: organ system; cytoplasmic part; intracellular organelle part; cell cycle; spindle; anatomical structure; female germline cyst; egg; protein complex; cytoskeletal part; peripheral nervous system. It has 2 annotated transcripts and 2 annotated polypeptides. [FlyBase]
    • Organism: Drosophila melanogaster
    Length: 4639 amino acids

    Gene Ontology:
    Cellular Component: cytoplasmic dynein complex [ISS]
    germline ring canal [TAS]
    ribonucleoprotein complex [IDA]
    cytoplasm [IDA][NAS]
    cell cortex [IDA]
    mitochondrion [IDA]
    Golgi apparatus [IDA]
    fusome [TAS]
    kinetochore [IDA]
    microtubule associated complex [IDA][NAS]
    Biological Process: spindle organization [IMP]
    regulation of mitotic metaphase/anaphase transition [IMP]
    centrosome cycle [IMP]
    axon cargo transport [IMP]
    germarium-derived oocyte fate determination [IMP][TAS]
    mitotic spindle organization [IMP]
    oocyte nucleus migration during oocyte axis specification [TAS]
    microtubule-based movement [IDA][ISS][NAS]
    intracellular protein transport [IMP]
    mitotic spindle stabilization [IMP]
    dendrite morphogenesis [IMP]
    centrosome localization [IMP]
    ovarian fusome organization [IMP]
    neuroblast proliferation [IMP]
    establishment of Golgi localization [IMP]
    mitochondrion transport along microtubule [IMP]
    RNA transport [IMP]
    cystoblast division [IMP]
    mushroom body development [IMP]
    intracellular mRNA localization [TAS]
    establishment of mitotic spindle localization [TAS]
    fusome organization [TAS]
    female germline ring canal formation [TAS]
    mitosis [IMP]
    positive regulation of mitotic centrosome separation [IMP]
    cellularization [IMP]
    oogenesis [IMP][NAS]
    mitochondrion distribution [IMP]
    germ-line cyst formation [TAS]
    maintenance of RNA location [IDA]
    Molecular Function: ATP binding [IEA]
    microtubule motor activity [IDA]
    ATPase activity, coupled [IDA][ISS][NAS]
    motor activity [ISS]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MGDSLENPDT SVDPIVNLSI ANYDAFANYL RKAVTILLPE DDVVPASLND ALDDPVNQDT  60
   61 IRKFLSDPQV QALYVQRNCI KEDDSEQPAE GEDEKEQVTY QISNDVHFTN SRMASLACIK 120
  121 RGLVVEADKS IHSQLRLINF SDGSPYETLH AFISKSLAPY FKSYVKESGR ADRDGDKMAP 180
  181 SVEKKLAELE MGLLHLQQNI DIPEITLTAH QTVNNVIRKC AEENRKAKVA DFGDKVEDSS 240
  241 FLNLLQNGVN RWIAEIKKVT KLNRDPGSGT ALQEISFWLN LERALYRIQE KRESPEVALT 300
  301 LDILKHGKRF HATVSFDTDT GLKQALATVA DYNPLMKDFP INDLLSATEL EKIRPAVQQI 360
  361 FAHLRKVRNT KYPIQRCLKL IEAISRDLSQ QLLKVLGTRR LMHIPFDEFE RVMNQCFEIF 420
  421 SCWDDEYDKL QGLLRDIVKK KRDEHLKMVW RVSPAHKKLQ TRMEHMRKFR RQHEQLRTVI 480
  481 LRVLRPTKPA VGDDGNVVET KQPYSLDAAD ANAIEEVNLA YENVKEVDCL DITKEGSEAW 540
  541 EAAVKRYEEK IDRVETRITA HLRDQLGTAK NANEMFRIFS RFNALFVRPH IRGAIREYQT 600
  601 QLIQRVKDDI EALHEKFKVQ YPQSKSCRLS SVRDLPPVAG SIIWARQIDN QLTMYLKRVE 660
  661 DVLGKGWETH IEGQKLKADG DSFRAKLSIS DVFHEWARKV QERNFGSTGR IFTIESTRSR 720
  721 IGRGNVLRLR VNFLPEIITL AKEVRNIKNL GFRVPLTIVN KAHQANQIYP YAISLIESVR 780
  781 TYERTLEKIE DRASIVPLVA GLRKDVLNLV SEGIGLIWES YKLDPYVIRL SECVTQFQEK 840
  841 VDDLLVVEEQ LDVDVRSLET CPYSAATFVE ILSKIQHAVD DLSLRQYSNL SVWVTRLDEE 900
  901 VEKKLALRLQ AGIQAWTEAL TGNKKEVDTS MDTDAPAQPT HKLGGDPQIQ NAVHEIRITN 960
  961 QQMYLYPSIE EARFQIMQQF FAWQAIVTSQ VRLQSTRYQV GLEKHVSQTY RNLLTKLPEG1020
 1021 KILENAYGAI EQKVSEVRNY VDEWLRYQSL WDLQADMLYG RLGEDVNLWI KCLNDIKQSR1080
 1081 TTFDTSDTRR AYGPIIIDYA KVQAKVTLKY DSWHKEALGK FGTLLGTEMT SFHSKVSKSR1140
 1141 TDLEMQSIEA ASTSDAVSFI TYVQSLKKDM IAWDKQVEVF REAQRILERQ RFQFPNTWLH1200
 1201 VDNIEGEWSA FNEIIKRKDT AIQTQVASLQ AKIVAEDKAV ETRTVDFLND WEKTKPTGGK1260
 1261 IRPDDALQQL QIFESKYSRL KEERDNVVKA KEALELQESA VPNNSAERMN VALEELQDLR1320
 1321 GVWSELSKVW TQIDETREKP WLSVQPRKLR QQLEAMMAQL KELPARLRMY ESYEYVKKLI1380
 1381 QSYIKVNMLI VELKSDALKE RHWKQLTKQL RVNWVLSDLS LGQVWDVNLQ KNEGIVKDII1440
 1441 LVAQGEMALE EFLKQVRESW QNYELDLINY QNKCRIIRGW DDLFNKVKEH INSVAAMKLS1500
 1501 PYYKVFEEEA LTWEEKLNRI NALFDVWIDV QRRWVYLEGI FSGSADIKTL LPVETSRFQS1560
 1561 ISSEFLGLMK KVTKSPKVMD VLNIPAVQRS LERLADLLGK IQKALGEYLE RERTSFPRFY1620
 1621 FVGDEDLLEI IGNSKNIARL QKHFKKMFAG VAAILLNEEN NVILGISSRE GEEVHFMNPV1680
 1681 STVEHPKINE WLSLVEKQMR FTLASLLAQA VQDIKQFRDG KIDPQAYMEW CDKYQAQIVV1740
 1741 LAAQILWSED VESALQQASE NNQSKPMQRV LGNVESTLNV LADSVLQEQP PLRRRKLEHL1800
 1801 INEFVHKRTV TRRLLNNGVT SPKSFQWLCE MRFYFDPRQT EVLQQLTIHM ANARFFYGFE1860
 1861 YLGVQDRLVQ TPLTDRCYLT MTQALESRLG GSPFGPAGTG KTESVKALGN QLGRFVLVFN1920
 1921 CDETFDFQAM GRIFVGLCQV GAWGCFDEFN RLEERMLSAC SQQIQTIQEA LKYEMDSNKE1980
 1981 SITVELVGKQ VRVSPDMAIF ITMNPGYAGR SNLPDNLKKL FRSLAMTTPD RQLIAEVMLF2040
 2041 SQGFRSAEKL ACKIVPFFKL CDEQLSNQSH YDFGLRALKS VLISAGNVKR DRIMKIKEQM2100
 2101 KQRGDENIDE ASVAENLPEQ EILIQSVCET MVPKLVAEDI PLLFSLLSDV FPNVGYTRAE2160
 2161 MKGLKEEIRK VCQEDYLVCG EGDEQGAAWM EKVLQLYQIS NLNHGLMMVG PSGSGKSTAW2220
 2221 KTLLKALERF EGVEGVAHVI DPKAISKEAL YGVLDPNTRE WTDGLFTHIL RKIIDNVRGE2280
 2281 INKRQWIIFD GDVDPEWVEN LNSVLDDNKL LTLPNGERLS LPPNVRVMFE VQDLKFATLA2340
 2341 TVSRCGMVWF SEDVLSTEMI FENYLSRLRS IPLEDGDEDF VGVIKPAKDK EEEVSPSLQV2400
 2401 QRDIALLLLP FFSADGIVVR TLEYAMDQEH IMDFTRLRAL SSLFSMLNQA ARNVLTFNAQ2460
 2461 HPDFPCSADQ LEHYIPKALV YSVLWSFAGD AKLKVRIDLG DFVRSVTTVP LPGAAGAPII2520
 2521 DYEVNMSGDW VPWSNKVPVI EVETHKVASP DIVVPTLDTV RHESLLYTWL AEHKPLVLCG2580
 2581 PPGSGKTMTL FSALRALPDM EVVGLNFSSA TTPELLLKTF DHYCEYRKTP NGVVLSPVQI2640
 2641 GKWLVLFCDE INLPDMDSYG TQRVISFLRQ LVEHKGFYRA SDQAWVSLER IQFVGACNPP2700
 2701 TDPGRKPLSH RFLRHVPIIY VDYPGETSLK QIYGTFSRAM LRLMPALRGY AEPLTNAMVE2760
 2761 FYLASQDRFT QDMQPHYVYS PREMTRWVRG ICEAIRPLDS LPVEGLVRLW AHEALRLFQD2820
 2821 RLVDDSERRW TNENIDLVGQ KHFPGINQEE ALQRPILYSN WLSKDYMPVN REELREYVHA2880
 2881 RLKVFYEEEL DVPLVLFDEV LDHVLRIDRI FRQPQGHLLL IGVSGAGKTT LSRFVAWMNG2940
 2941 LSIFQIKVHN KYTSEDFDED LRCVLRRSGC KDEKIAFILD ESNVLDSGFL ERMNTLLANG3000
 3001 EVPGLFEGDE YTTLMTQCKE GAQREGLMLD SSDELYKWFT QQVMRNLHVV FTMNPSTDGL3060
 3061 KDRAATSPAL FNRCVLNWFG DWSDSALFQV GKEFTTRVDL EKPNWHAPDF FPSVCPLVPA3120
 3121 NPTHRDAVIN SCVYVHQTLH QANARLAKRG GRTMAVTPRH YLDFIHHFVK LYNEKRSDLE3180
 3181 EQQLHLNVGL NKIAETVEQV EEMQKSLAVK KQELQAKNEA ANAKLKQMFQ DQQEAEKKKI3240
 3241 QSQEIQIRLA DQTVKIEEKR KYVMADLAQV EPAVIDAQAA VKSIRKQQLV EVRTMANPPS3300
 3301 VVKLALESIC LLLGENATDW KSIRAVIMRE NFINSIVSNF GTENITDDVR EKMKSKYLSN3360
 3361 PDYNFEKVNR ASMACGPMVK WAIAQIEYAD MLKRVEPLRE ELRSLEEQAD VNLASAKETK3420
 3421 DLVEQLERSI AAYKEEYAQL ISQAQAIKTD LENVQAKVDR SIALLKSLNI ERERWESTSE3480
 3481 TFKSQMSTII GDVLLSAAFI AYGGYFDQHY RLNLFTTWSQ HLQAASIQYR ADIARTEYLS3540
 3541 NPDERLRWQA NALPTDDLCT ENAIMLKRFN RYPLIIDPSG QATTFLLNEY AGKKITKTSF3600
 3601 LDDSFRKNLE SALRFGNPLL VQDVENYDPI LNPVLNRELR RTGGRVLITL GDQDIDLSPS3660
 3661 FVIFLSTRDP TVEFPPDICS RVTFVNFTVT RSSLQSQCLN QVLKAERPDI DEKRSDLLKL3720
 3721 QGEFRLRLRQ LEKSLLQALN DAKGKILDDD SVITTLETLK KEAYDINQKV DETDKVIAEI3780
 3781 ETVSQQYLPL SVACSNIYFT MDSLNQVHFL YQYSLKMFLD IFSTVLYNNP KLEGRTDHSE3840
 3841 RLGIVTRDLF QVCYERVARG MIHIDRLTFA LLMCKIHLKG TSESNLDAEF NFFLRSREGL3900
 3901 LANPTPVEGL SAEQIESVNR LALRLPIFRK LLEKVRSIPE LGAWLQQSSP EQVVPQLWDE3960
 3961 SKALSPIASS VHQLLLIQAF RPDRVIAAAH NVVNTVLGED FMPNAEQELD FTSVVDKQLN4020
 4021 CNTPALLCSV PGFDASGRVD DLAAEQNKQI SSIAIGSAEG FNQAERAINM ACKTGRWVLL4080
 4081 KNVHLAPQWL VQLEKKMHSL QPHSGFRLFL TMEINPKVPV NLLRAGRIFV FEPPPGIRAN4140
 4141 LLRTFSTVPA ARMMKTPSER ARLYFLLAWF HAIVQERLRY VPLGWAKKYE FNESDLRVAC4200
 4201 DTLDTWIDTT AMGRTNLPPE KVPWDALVTL LSQSIYGGKI DNDFDQRLLT SFLKKLFTAR4260
 4261 SFEADFALVA NVDGASGGLR HITMPDGTRR DHFLKWIENL TDRQTPSWLG LPNNAEKVLL4320
 4321 TTRGTDLVSK LLKMQQLEDD DELAYSVEDQ SEQSAVGRGE DGRPSWMKTL HNSATAWLEL4380
 4381 LPKNLQVLKR TVENIKDPLY RYFEREVTSG SRLLQTVILD LQDVVLICQG EKKQTNHHRS4440
 4441 MLSELVRGII PKGWKRYTVP AGCTVIQWIT DFSNRVQQLQ KVSQLVSQAG AKELQGFPVW4500
 4501 LGGLLNPEAY ITATRQCVAQ ANSWSLEELA LDVTITDAGL KNDQKDCCFG VTGLKLQGAQ4560
 4561 CKNNELLLAS TIMMDLPVTI LKWIKISSEP RISKLTLPVY LNSTRTELLF TVDLAVAAGQ4620
 4621 ESHSFYERGV AVLTSTALN

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

    No microscopy data found in the PDR for this protein.

    Protein Structure Data



    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.95

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle