Protein Overview: trio-PE

General Information:
Name(s) found:	trio-PE / FBpp0072543 [FlyBase]
Description(s) found: Found 20 descriptions. SHOW ALL	The gene trio is referred to in FlyBase by the symbol Dmel\trio (CG18214, FBgn0024277). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 3L:995982..1034875. It has the cytological map location 61E1-61E2. There is experimental evidence that it has the molecular function</span>: Rho guanyl-nucleotide exchange factor activity. There is experimental evidence that it is involved in the biological process</span>: central nervous system development; regulation of axonogenesis; Rho protein signal transduction; actin cytoskeleton organization; axon guidance; peripheral nervous system development. 77 alleles are reported. The phenotypes of these alleles are annotated with 18 unique terms, many of which group under: nervous system; multi-cell-component structure; organ system; embryonic nervous system; commissure; adult segment; peripheral nervous system; adult brain; FBbt:00003689; abdominal segmental nerve; FBbt:00003692; embryonic neuron; external compound sense organ. It has 6 annotated transcripts and 6 annotated polypeptides. [FlyBase]
Organism:	Drosophila melanogaster
Length:	398 amino acids
Gene Ontology:
Cellular Component:	plasma membrane [IDA] intracellular [IEA]
Biological Process:	regulation of Rho protein signal transduction [IEA] central nervous system development [IGI][IMP] regulation of axonogenesis [IGI] peripheral nervous system development [IGI][IMP] axon guidance [IGI][IMP][TAS] Rho protein signal transduction [IDA] actin cytoskeleton organization [IDA][IEP]
Molecular Function:	Rho guanyl-nucleotide exchange factor activity [IDA][ISS][NAS]

Sequence:

Sequence:
[PDR BLAST]
[ProtParam]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSCFFRLFAS PGKMDGNPLS EIEEIVKTTT EQHESNSRVD GGGGVENAST NGHGRSHDNN  60
   61 DESHTAVSDK AAALKKRQCV FAELMSTEEA YVQDLHEIVN GYMTEINNTN SDIPMPEDLK 120
  121 GGKMKLVFNN IKDIYEWHRD FFLRALRNCQ KSPADLGPLI KRSATKFALY YTYCSNKPLS 180
  181 EYIVSAHYQY FDSIRQKLGH RLDLSNLIIK PVQRITKYEL LIKEIIKATE GAGLYKEVPM 240
  241 LQEAYQQMKV VVKTVNDMMV VLRSLQDFDG EITAQGSLLM QGPMNCVVDA AQKHRELQVF 300
  301 LFQQIIIFAD IEKTKNQYAS PIFKYRSHIQ LNHMQMKELG DCRFQIRSTD PKIPEMTIIC 360
  361 QAASQENYAG WRDMLNKILQ QQNDLIFMLS NPLSTKNK

Protein Complex Data

No complex found for this protein.

Mass Spectrometry Data

No mass spectrometry results found for this protein.

Yeast Two-Hybrid Data

The following interactions contain this protein:

SHOWING SINGLE HITS. [ Hide Single Hits ]

[View our yeast two-hybrid interpretation guidelines.]

No yeast two-hybrid interactions found for this protein.

Protein predicted to be:	GLOBULAR (No transmembrane regions or signal peptide)
Confidence of classification:	0.99

Protein Overview: trio-PE

Protein Complex Data

Mass Spectrometry Data

Yeast Two-Hybrid Data

Microscopy / Localization Data

Protein Structure Data

Philius Transmembrane Prediction: