Protein Overview: trio-PB, trio-PF

General Information:
Name(s) found:	trio-PF / FBpp0089283 [FlyBase] trio-PB / FBpp0072542 [FlyBase]
Description(s) found: Found 31 descriptions. SHOW ALL	The gene trio is referred to in FlyBase by the symbol Dmel\trio (CG18214, FBgn0024277). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 3L:995982..1034875. It has the cytological map location 61E1-61E2. There is experimental evidence that it has the molecular function</span>: Rho guanyl-nucleotide exchange factor activity. There is experimental evidence that it is involved in the biological process</span>: central nervous system development; regulation of axonogenesis; Rho protein signal transduction; actin cytoskeleton organization; axon guidance; peripheral nervous system development. 77 alleles are reported. The phenotypes of these alleles are annotated with 18 unique terms, many of which group under: nervous system; multi-cell-component structure; organ system; embryonic nervous system; commissure; adult segment; peripheral nervous system; adult brain; FBbt:00003689; abdominal segmental nerve; FBbt:00003692; embryonic neuron; external compound sense organ. It has 6 annotated transcripts and 6 annotated polypeptides. [FlyBase] The gene trio is referred to in FlyBase by the symbol Dmel\trio (CG18214, FBgn0024277). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 3L:995982..1034875. It has the cytological map location 61E1-61E2. There is experimental evidence that it has the molecular function</span>: Rho guanyl-nucleotide exchange factor activity. There is experimental evidence that it is involved in the biological process</span>: central nervous system development; regulation of axonogenesis; Rho protein signal transduction; actin cytoskeleton organization; axon guidance; peripheral nervous system development. 77 alleles are reported. The phenotypes of these alleles are annotated with 18 unique terms, many of which group under: nervous system; multi-cell-component structure; organ system; embryonic nervous system; commissure; adult segment; peripheral nervous system; adult brain; FBbt:00003689; abdominal segmental nerve; FBbt:00003692; embryonic neuron; external compound sense organ. It has 6 annotated transcripts and 6 annotated polypeptides. [FlyBase]
Organism:	Drosophila melanogaster
Length:	658 amino acids
Gene Ontology:
Cellular Component:	plasma membrane [IDA] intracellular [IEA]
Biological Process:	regulation of Rho protein signal transduction [IEA] central nervous system development [IGI][IMP] regulation of axonogenesis [IGI] peripheral nervous system development [IGI][IMP] axon guidance [IGI][IMP][TAS] Rho protein signal transduction [IDA] actin cytoskeleton organization [IDA][IEP]
Molecular Function:	Rho guanyl-nucleotide exchange factor activity [IDA][ISS][NAS]

Sequence:

Sequence:
[PDR BLAST]
[ProtParam]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MCNNNNNNNS DCGHRSRLDK MAENGFHYKS ASAVPGTTVC CDNNNEASNP HPEPNYNSLK  60
   61 LKRSSAPAHS RPKSMHKLFK SISLRVGDNG NANGNGKGNG NGNGNAAVLH HQQSLGGQPS 120
  121 GFTCVCCEEV TEIRTENPKR RNSFLKELKK RRNWLPLMNR KGTDKPPSSK PLVKKPSEKN 180
  181 LRTPQKHAEE LAEQQNQQPG ASPATVLPSS QFPSSTQHPG GAGAGDYEPD EEVGLELPPP 240
  241 MKPIQEPHLI ANGPPAFAKD AKESSGNMAS PGKMDGNPLS EIEEIVKTTT EQHESNSRVD 300
  301 GGGGVENAST NGHGRSHDNN DESHTAVSDK AAALKKRQCV FAELMSTEEA YVQDLHEIVN 360
  361 GYMTEINNTN SDIPMPEDLK GGKMKLVFNN IKDIYEWHRD FFLRALRNCQ KSPADLGPLI 420
  421 KRSATKFALY YTYCSNKPLS EYIVSAHYQY FDSIRQKLGH RLDLSNLIIK PVQRITKYEL 480
  481 LIKEIIKATE GAGLYKEVPM LQEAYQQMKV VVKTVNDMMV VLRSLQDFDG EITAQGSLLM 540
  541 QGPMNCVVDA AQKHRELQVF LFQQIIIFAD IEKTKNQYAS PIFKYRSHIQ LNHMQMKELG 600
  601 DCRFQIRSTD PKIPEMTIIC QAASQENYAG WRDMLNKILQ QQNDLIFMLS NPLSTKNK

Protein Complex Data

No complex found for this protein.

Mass Spectrometry Data

No mass spectrometry results found for this protein.

Yeast Two-Hybrid Data

The following interactions contain this protein:

NOT SHOWING SINGLE HITS. [ Show Single Hits ]

[View our yeast two-hybrid interpretation guidelines.]

No yeast two-hybrid interactions found for this protein.

Protein predicted to be:	GLOBULAR (No transmembrane regions or signal peptide)
Confidence of classification:	0.99

Protein Overview: trio-PB, trio-PF

Protein Complex Data

Mass Spectrometry Data

Yeast Two-Hybrid Data

Microscopy / Localization Data

Protein Structure Data

Philius Transmembrane Prediction: