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Protein Overview: Ptpmeg-PA, Ptpme...

General Information:
Name(s) found: Ptpmeg-PF / FBpp0291032 [FlyBase]
Ptpmeg-PE / FBpp0291031 [FlyBase]
Ptpmeg-PC / FBpp0072444 [FlyBase]
Ptpmeg-PA / FBpp0072443 [FlyBase]
Ptpmeg-PD / FBpp0072441 [FlyBase]
Description(s) found:
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  • gi|24654738|ref|NP_728523.1| ptpmeg, isoform D [Drosophila melanogaster] [NCBI NR]
  • gi|24654735|ref|NP_612031.2| ptpmeg, isoform C [Drosophila melanogaster] [NCBI NR]
  • gi|24654733|ref|NP_728522.1| ptpmeg, isoform A [Drosophila melanogaster] [NCBI NR]
  • gi|23092703|gb|AAN11442.1| ptpmeg, isoform D [Drosophila melanogaster] [NCBI NR]
  • gi|23092702|gb|AAN11441.1| ptpmeg, isoform C [Drosophila melanogaster] [NCBI NR]
  • gi|23092701|gb|AAF47380.2| ptpmeg, isoform A [Drosophila melanogaster] [NCBI NR]
  • The gene Ptpmeg is referred to in FlyBase by the symbol Dmel\Ptpmeg (CG1228, FBgn0035133). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 3L:328099..356050. It has the cytological map location 61C1. Based on sequence similarity, it is predicted to have molecular function</span>: protein tyrosine phosphatase activity; cytoskeletal protein binding. There is experimental evidence that it is involved in the biological process</span>: axon extension involved in axon guidance; mushroom body development; autophagic cell death; salivary gland cell autophagic cell death; central complex development. 40 alleles are reported. The phenotypes of these alleles are annotated with: eye; mushroom body beta-lobe; mushroom body medial lobe; mushroom body vertical lobe; mushroom body alpha-lobe. It has 6 annotated transcripts and 6 annotated polypeptides. [FlyBase]
  • >CG1228-PC translation from_gene[CG1228 Ptpmeg FBgn0035133] seq_release:3 mol_weight=106963 cds_boundaries:(3L:332,256..336,154[+]) aa_length:952 transcript_info:[CG1228-RC seq_release:3] gene_info:[gene symbol:Ptpmeg FBgn0035133 gene_boundaries:(3L:30 [hmr_yeast5_DM3-1_pombe.fasta]
  • >CG1228-PA translation from_gene[CG1228 Ptpmeg FBgn0035133] seq_release:3 mol_weight=106963 cds_boundaries:(3L:332,256..336,154[+]) aa_length:952 transcript_info:[CG1228-RA seq_release:3] gene_info:[gene symbol:Ptpmeg FBgn0035133 gene_boundaries:(3L:30 [hmr_yeast5_DM3-1_pombe.fasta]
  • >CG1228-PD translation from_gene[CG1228 Ptpmeg FBgn0035133] seq_release:3 mol_weight=106963 cds_boundaries:(3L:332,256..336,154[+]) aa_length:952 transcript_info:[CG1228-RD seq_release:3] gene_info:[gene symbol:Ptpmeg FBgn0035133 gene_boundaries:(3L:30 [hmr_yeast5_DM3-1_pombe.fasta]
  • (Q9W0R3) CG1228 protein [DrosMelano7227.FASTAC.txt]
  • CG1228-PD, isoform D [Drosophila melanogaster]gi|23092702|gb|AAN11441.1| CG1228-PC, isoform C [Drosophila melanogaster]gi|23092701|gb|AAF47380.2| CG1228-PA, isoform A [Drosophila melanogaster]gi|24654738|ref|NP_728523.1| CG1228-PD [Drosophila melanogas [nrdb_11152004_Chlamydomonas]
  • type=protein; loc=3L:join(351626..351778,352300..352407,352476..352568,352630..352771,352838..353118,353185..353687,353761..354446,354500..355124,355199..355376,355438..355527); ID=FBpp0072444; name=Ptpmeg-PC; parent=FBgn0035133,FBtr0072545; dbxref=FlyBas [fly-100309-contam.fasta]
  • type=protein; loc=3L:join(351626..351778,352300..352407,352476..352568,352630..352771,352838..353118,353185..353687,353761..354446,354500..355124,355199..355376,355438..355527); ID=FBpp0072441; name=Ptpmeg-PD; parent=FBgn0035133,FBtr0072542; dbxref=FlyBas [fly-100309-contam.fasta]
  • type=protein; loc=3L:join(351626..351778,352300..352407,352476..352568,352630..352771,352838..353118,353185..353687,353761..354446,354500..355124,355199..355376,355438..355527); ID=FBpp0072443; name=Ptpmeg-PA; parent=FBgn0035133,FBtr0072544; dbxref=FlyBas [fly-100309-contam.fasta]
  • CG1228-PC, isoform C [Drosophila melanogaster] [nr-271106-contam.fasta]
  • Ptpmeg CG1228-PD, isoform D [Drosophila melanogaster] [nr-271106-contam.fasta]
  • Ptpmeg CG1228-PC, isoform C [Drosophila melanogaster] [nr-271106-contam.fasta]
  • CG1228-PD, isoform D [Drosophila melanogaster] [nr-271106-contam.fasta]
  • Ptpmeg CG1228-PA, isoform A [Drosophila melanogaster] [nr-271106-contam.fasta]
  • CG1228-PA, isoform A [Drosophila melanogaster] [nr-271106-contam.fasta]
  • type=protein; loc=3L:join(351626..351778,352300..352407,352476..352568,352630..352771,352838..353118,353185..353687,353761..354446,354500..355124,355199..355376,355438..355527); ID=FBpp0072444; name=Ptpmeg-PC; parent=FBgn0035133,FBtr0072545; dbxref=FlyBase_Annotation_IDs:CG1228-PC,FlyBase:FBpp0072444,GB_protein:AAN11441.1,REFSEQ:NP_612031,GB_protein:AAN11441; MD5=eca5ab2d6c45c6f8eb2256aadbba3eeb; length=952; release=r5.16; species=Dmel; [fly-contam-His-TEV-Tub4complex.fasta]
  • type=protein; loc=3L:join(351626..351778,352300..352407,352476..352568,352630..352771,352838..353118,353185..353687,353761..354446,354500..355124,355199..355376,355438..355527); ID=FBpp0072441; name=Ptpmeg-PD; parent=FBgn0035133,FBtr0072542; dbxref=FlyBase:FBpp0072441,FlyBase_Annotation_IDs:CG1228-PD,GB_protein:AAN11442.1,REFSEQ:NP_728523,GB_protein:AAN11442; MD5=eca5ab2d6c45c6f8eb2256aadbba3eeb; length=952; release=r5.16; species=Dmel; [fly-contam-His-TEV-Tub4complex.fasta]
  • type=protein; loc=3L:join(351626..351778,352300..352407,352476..352568,352630..352771,352838..353118,353185..353687,353761..354446,354500..355124,355199..355376,355438..355527); ID=FBpp0072443; name=Ptpmeg-PA; parent=FBgn0035133,FBtr0072544; dbxref=FlyBase:FBpp0072443,FlyBase_Annotation_IDs:CG1228-PA,GB_protein:AAF47380.2,REFSEQ:NP_728522,GB_protein:AAF47380; MD5=eca5ab2d6c45c6f8eb2256aadbba3eeb; length=952; release=r5.16; species=Dmel; [fly-contam-His-TEV-Tub4complex.fasta]
  • type=protein; loc=3L:join(351626..351778,352300..352407,352476..352568,352630..352771,352838..353118,353185..353687,353761..354446,354500..355124,355199..355376,355438..355527); ID=FBpp0072444; name=Ptpmeg-PC; parent=FBgn0035133,FBtr0072545; dbxref=FlyBase_Annotation_IDs:CG1228-PC,FlyBase:FBpp0072444,GB_protein:AAN11441.1,REFSEQ:NP_612031,GB_protein:AAN11441; MD5=eca5ab2d6c45c6f8eb2256aadbba3eeb; length=952; release=r5.21; species=Dmel; [Other_drosophila_na_09-09-2009_reversed.fasta]
  • type=protein; loc=3L:join(351626..351778,352300..352407,352476..352568,352630..352771,352838..353118,353185..353687,353761..354446,354500..355124,355199..355376,355438..355527); ID=FBpp0072441; name=Ptpmeg-PD; parent=FBgn0035133,FBtr0072542; dbxref=FlyBase:FBpp0072441,FlyBase_Annotation_IDs:CG1228-PD,GB_protein:AAN11442.1,REFSEQ:NP_728523,GB_protein:AAN11442; MD5=eca5ab2d6c45c6f8eb2256aadbba3eeb; length=952; release=r5.21; species=Dmel; [Other_drosophila_na_09-09-2009_reversed.fasta]
  • type=protein; loc=3L:join(351626..351778,352300..352407,352476..352568,352630..352771,352838..353118,353185..353687,353761..354446,354500..355124,355199..355376,355438..355527); ID=FBpp0072443; name=Ptpmeg-PA; parent=FBgn0035133,FBtr0072544; dbxref=FlyBase:FBpp0072443,FlyBase_Annotation_IDs:CG1228-PA,GB_protein:AAF47380.2,REFSEQ:NP_728522,GB_protein:AAF47380; MD5=eca5ab2d6c45c6f8eb2256aadbba3eeb; length=952; release=r5.21; species=Dmel; [Other_drosophila_na_09-09-2009_reversed.fasta]
  • type=protein; loc=3L:join(351626..351778,352300..352407,352476..352568,352630..352771,352838..353118,353185..353687,353761..354446,354500..355124,355199..355376,355438..355527); ID=FBpp0291031; name=Ptpmeg-PE; parent=FBgn0035133,FBtr0301817; dbxref=FlyBase:FBpp0291031,FlyBase_Annotation_IDs:CG1228-PE; MD5=eca5ab2d6c45c6f8eb2256aadbba3eeb; length=952; release=r5.21; species=Dmel; [Other_drosophila_na_09-09-2009_reversed.fasta]
  • type=protein; loc=3L:join(351626..351778,352300..352407,352476..352568,352630..352771,352838..353118,353185..353687,353761..354446,354500..355124,355199..355376,355438..355527); ID=FBpp0291032; name=Ptpmeg-PF; parent=FBgn0035133,FBtr0301818; dbxref=FlyBase:FBpp0291032,FlyBase_Annotation_IDs:CG1228-PF; MD5=eca5ab2d6c45c6f8eb2256aadbba3eeb; length=952; release=r5.21; species=Dmel; [Other_drosophila_na_09-09-2009_reversed.fasta]
  • Ptpmeg, isoform A OS=Drosophila melanogaster GN=Ptpmeg PE=2 SV=2 [UniProt_drosophila_07-01-2011_reversed.fasta]
    • Organism: Drosophila melanogaster
    Length: 952 amino acids

    Gene Ontology:
    Cellular Component: cytoskeleton [IEA]
    cytoplasm [IEA]
    extrinsic to membrane [IEA]
    Biological Process: mushroom body development [IMP]
    autophagic cell death [IEP]
    central complex development [IMP]
    protein amino acid dephosphorylation [IEA][NAS]
    salivary gland cell autophagic cell death [IEP]
    axon extension involved in axon guidance [IMP]
    Molecular Function: protein tyrosine phosphatase activity [ISS][NAS]
    cytoskeletal protein binding [IEA][ISS]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MFERFRLNNL TRTFRLRGGG PELARDKKTP QRQQCVTVLF LDDITHTFRI EKRAKGSELL  60
   61 DQVFQYLELS ERDYFGLLFP QKPGDVVRWV DAQKQFKKQC SSVSLDNDAV PLLEFRVKFF 120
  121 VSDPSRLQEE FTRYQFYLQI KRNILLGKLP CSSNTQCLLA SYTVQSELGD FNALEHQPGY 180
  181 LSGMQLLCDQ TTEAERKVGE LHKLHRGQLP ADAEYNYLEH AKRLELYGID LHRATDSNGK 240
  241 ELQLGVSAVG LLVFQHSLRL RREPSENYDT LLGFGMSSHK HAKALWKSCV EHHSFFRLKR 300
  301 PHRLSRFLNI SLGSKFYYSG RTELQAVQES KQRGRIHKVF VRSPSKRLLG AAGGVGTSGS 360
  361 SGGTPMQQHS GSESANSHNN GKPAGAGTIL TITKTSRPHD NKVTSKEADS MPRKAWEQQS 420
  421 DEYDIQLDVG FIEQCTRRFE SASPSPMPPA YSSGQHSPIL LPTTIADAVG HQQPESGSDL 480
  481 ITIRLQADEQ GRYGFNVKGG VDLSLPVQVS KVVPHTPADR CTPRVCEGDE VLMINGRDVH 540
  541 GLRHEQVVAM IRDCRHQASG ELLLTVRPQR SAPLLLEEEP LYQYVPESDE IGSHSNLLDG 600
  601 DALFTQSLLL LSDGLASGAL LAQYELMYRK NPDLAITEAR KPANAPKNRY RDISPYDCTR 660
  661 VSLVNSLTGD YINANYVNME IPGGAVNRYI ATQGPLASTT TDFWRMVQQE SSHLLVMLTT 720
  721 VMESGRQKCH QYWPVTGEEL QLAEGFSVRC LSEKPDETGS FVFREFVLKD KHEQRHIHHM 780
  781 QYLAWPDHCV PSDPNLFLEF TERVRAARNR TLLQEIEESL KQVRLMDADA DADENGGLMR 840
  841 ERKCAASNGA TPEDETPVST SVHQCISAAN PPVIVHCSAG IGRTGVLILM DTALALMEAR 900
  901 EPVYPLDIVR TMRDQRACMV QNVSQYRFVC ECICAAYMKI SRSSAAINDD ED

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    SHOWING SINGLE HITS. [ Hide Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data



    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.94

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle