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Protein Overview: gol-PB

General Information:
Name(s) found: gol-PB / FBpp0072361 [FlyBase]
Description(s) found:
Found 22 descriptions.
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  • The gene goliath is referred to in FlyBase by the symbol Dmel\gol (CG2679, FBgn0004919). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 2R:20960150..20971843. It has the cytological map location 60F3. There is experimental evidence that it has the molecular function</span>: transcription regulator activity. There is experimental evidence that it is involved in the biological process</span>: regulation of transcription; mesoderm formation. 6 alleles are reported. No phenotypic data is available. It has 3 annotated transcripts and 3 annotated polypeptides. [FlyBase]
    • Organism: Drosophila melanogaster
    Length: 461 amino acids

    Gene Ontology:
    Cellular Component: nucleus [NAS]
    Biological Process: mesoderm development [NAS]
    regulation of transcription, DNA-dependent [NAS]
    mesoderm formation [IEP]
    regulation of transcription [IEP]
    Molecular Function: zinc ion binding [IEA]
    protein binding [IEA]
    transcription regulator activity [IEP]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MYIRKTLLLA CLVLLFGGLP PLTFPATTTT LVAAMSIANQ DLERYFRPGN GTHSFSGMED  60
   61 RIAVDVYNYA FLNWSYVEHG NMLCNMEFAQ EQARYGEGKV LNVTGRLIHI TATDNFSDDY 120
  121 ACTPYIRGTL GAPIPDKGET WIALVRRGRC TFEEKVKHVY QQNAAGVIIY NDKQVMQLEK 180
  181 MQIKGKTRNI AAVITYQNIG QDLSLTLDKG YNVTISIIEG RRGVRTISSL NRTSVLFVSI 240
  241 SFIVLMIISL VWLIFYYIQR FRYMQAKDQQ SRNLCSVTKK AIMKIPTKTG KFSDEKDLDS 300
  301 DCCAICIEAY KPTDTIRILP CKHEFHKNCI DPWLIEHRTC PMCKLDVLKF YGYVFLGSEE 360
  361 SILEYQPDPP QGLALVEARD ESADLNRSRD FVVDFPRVFV LDSGCVVGAR EMLFPCRIPE 420
  421 RSQSSLSLRQ ARDWVSLMSN KLEEQQGLRS MRNDEMQQVI K

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..163] PSI-BLAST 7.69897 Structure of C5a peptidase- a key virulence factor from Streptococcus
    2 View Details [164..356] PSI-BLAST 12.0 Cbl; N-terminal domain of cbl (N-cbl); CBL
    3 View Details [357..461] MSA 2.784992 View MSA. No confident structure predictions are available.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2
    Term Confidence Notes
  • binding
    		•  3.12724619324809 bayes_pls_golite062009
  • transcription regulator activity
    		•  2.32209932468336 bayes_pls_golite062009
  • protein binding
    		•  2.14586566310919 bayes_pls_golite062009
  • nucleic acid binding
    		•  2.09146786953566 bayes_pls_golite062009
  • DNA binding
    		•  1.92481088182068 bayes_pls_golite062009
  • transcription factor activity
    		•  1.22542472051838 bayes_pls_golite062009
  • calcium ion binding
    		•  0.9587727543737 bayes_pls_golite062009
  • molecular adaptor activity
    		•  0.494024302340603 bayes_pls_golite062009
  • SH3/SH2 adaptor activity
    		•  0.409062479526042 bayes_pls_golite062009
  • protein binding, bridging
    		•  0.370788151516215 bayes_pls_golite062009
  • signal transducer activity
    		•  0.150891693412241 bayes_pls_golite062009
  • molecular transducer activity
    		•  0.150891693412241 bayes_pls_golite062009
  • cytoskeletal protein binding
    		•  0.0128369896420697 bayes_pls_golite062009
    3 No functions predicted.


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    [View Details]
    Source: Reynolds et al. 2008. Manuscript submitted Philius confidence legend
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