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Protein Overview: Atf-2-PA

General Information:
Name(s) found: Atf-2-PA / FBpp0072288 [FlyBase]
Description(s) found:
Found 16 descriptions.
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  • The gene Activating transcription factor-2 is referred to in FlyBase by the symbol Dmel\Atf-2 (CG30420, FBgn0050420). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 2R:20757590..20767817. It has the cytological map location 60E4-60E5. There is experimental evidence that it has the molecular function</span>: transcription factor activity; sequence-specific DNA binding; transcription activator activity; protein homodimerization activity. There is experimental evidence that it is involved in the biological process</span>: positive regulation of gene-specific transcription from RNA polymerase II promoter; response to salt stress; regulation of triglyceride biosynthetic process; stress-activated MAPK cascade; mucosal immune response. 27 alleles are reported. The phenotypes of these alleles are annotated with: larval fat body; wing vein. It has 3 annotated transcripts and 3 annotated polypeptides. [FlyBase]
    • Organism: Drosophila melanogaster
    Length: 850 amino acids

    Gene Ontology:
    Cellular Component: nucleus [IDA]
    integral to membrane [IEA]
    Biological Process: response to salt stress [IMP]
    regulation of transcription, DNA-dependent [IEA]
    regulation of triglyceride biosynthetic process [IMP]
    positive regulation of gene-specific transcription from RNA polymerase II promoter [IDA]
    mucosal immune response [IMP]
    stress-activated MAPK cascade [IDA]
    Molecular Function: transcription factor activity [IGI]
    protein homodimerization activity [IDA][ISS]
    sequence-specific DNA binding [IDA]
    transcription activator activity [IDA]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MDTAGDMDHL ASVSFGDFET KSPEGDVSCY QNFRAQTEHV SLDISLGQKS DTLFAADQTP  60
   61 TPTRLIKNCD EVGLFEDLQH VNPFDIGFQQ AAERNVSGTP SRPEARPNDG ESLHTPQVYP 120
  121 VEAPTVVSVP SENQVPQSVS CGDMDVDQLL ATTVTSPSKA SQDGPPPLQL IQPQVLTWVL 180
  181 PAQSVPISIA TVDCNRNRVK PTGAIHPFIL PKPTAKELNK TSKRPEPILV SCNPPNNEPS 240
  241 SASLTPTSQL PIKERLKAII HSNNNRRSFS TPPKAAKAKD RSRDEDCMER RRAAASRYRN 300
  301 KMRNEHKDLI KQNAQLQQEN QELHERISRL EKELQQHRSH SSLAGGLRRR PIQPPVMDPQ 360
  361 SEQEYAFLAQ MMEQYARRRL QQQFDQQLHE INLKMDRQRQ LLEQERYRQR QQELQVQREA 420
  421 EEDYESNGNN LNQQYDQYDN AEAEASYGSP MEAVSDLQSP PLYLPRLPNL PPLPSLPNRP 480
  481 SLGNSPNRNS VLRERIPFAV GPSDARFFDN PNDPSGELDS RALEDYEEYA PIEPTTEVAT 540
  541 TASKTKIDTP VPAPVPVEPP KLLDAANTNF HRINPQSAAA AAVAGVNIPQ SKEQPPHELN 600
  601 ALINKLQKQS KAPSHLTLVN GGDSSQEQIV LRQHLGMNSE MGVYIVALIA GVSAAVTVGL 660
  661 LALGVTWFHN RHKAAADVEY PAYGVTGPNK DVSPSGDRKL AQSAQMYHYQ HQKQQIIAME 720
  721 NQATDGSCGM SDVESDDDNE EGDYTVYECP GLAPTGEMEV KNPLFLDETP ATPSNNLSSQ 780
  781 TAGAANAAAA TNNNITQATP QQPATLKKGT VKPNINLLNA TGTAAAAASA ASAASATGGE 840
  841 EPKQKRKSKK

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


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    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..287] PSI-BLAST 3.522879 Sec24
    2 View Details [288..611] PSI-BLAST 16.09691 Heavy meromyosin subfragment
    3 View Details [612..767] MSA 3.024978 View MSA. No confident structure predictions are available.
    4 View Details [768..850] deduced N/A No confident structure predictions are available.


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    [View Details]
    Source: Reynolds et al. 2008. Manuscript submitted Philius confidence legend
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