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Protein Overview: Alas-PA

General Information:
Name(s) found: Alas-PA / FBpp0072060 [FlyBase]
Description(s) found:
Found 25 descriptions.
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  • The gene Aminolevulinate synthase is referred to in FlyBase by the symbol Dmel\Alas (CG3017, FBgn0020764). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 2R:19852224..19854271. It has the cytological map location 60A14. Based on sequence similarity, it is predicted to have molecular function</span>: 5-aminolevulinate synthase activity. Based on sequence similarity, it is predicted to be involved in the biological process</span>: heme biosynthetic process. 3 alleles are reported. No phenotypic data is available. It has one annotated transcript and one annotated polypeptide. [FlyBase]
    • Organism: Drosophila melanogaster
    Length: 539 amino acids

    Gene Ontology:
    Cellular Component: mitochondrial matrix [ISS]
    mitochondrion [RCA]
    Biological Process: heme biosynthetic process [ISS]
    Molecular Function: pyridoxal phosphate binding [IEA]
    transferase activity, transferring nitrogenous groups [IEA]
    5-aminolevulinate synthase activity [ISS][NAS]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MQCPFLNRFT ASFIRNYAET LCQSYGSHCP VVGKTLVSGE KKLSLVAASV TRSHSTGANA  60
   61 HANAGGPATA NATAPVSAPA SADPGKASAK ETFPYERFFN EQIMKKKRDH SYRVFKKVNR 120
  121 LAGDGLFPHA LEYSERTEKP ITVWCSNDYL GMSAHPGVKR AVQDALNRHG SGAGGTRNIS 180
  181 GNSLHHERLE SKLAELHQKE AALLFTSCFV ANDSTLFTLA KLLPGCEIFS DAGNHASMIM 240
  241 GIRNSGVPKH IFRHNDVDHL HQLLKQTDKS VPKIVAFETV HSMTGAICPL EELLDVAHEH 300
  301 GAITFIDEVH AVGLYGDHGA GVGERDGVLH KMDIISGTLG KAFGNIGGYI AGTHNLVDMI 360
  361 RSYAAGFIFT TSLPPTVLCG ALEAVNILAS EEGRQLRHLH QRNVSYLKSL LKREGFPVEE 420
  421 TPSHIIPIKI GDPLKSSQIS NVLIEQFGHY LQSINYPTVA RGQEKLRLAP TPFHTFEMMN 480
  481 ALVTDLKKVW EMVDLSTNVP LSPNACMFCN SESCWHQDTS PDLECGIPNC PRLEISLAA

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..92] deduced N/A No confident structure predictions are available.
    2 View Details [93..539] PSI-BLAST 90.522879 5-Aminolevulinate Synthase from Rhodobacter capsulatus

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2
    Term Confidence Notes
  • C-palmitoyltransferase activity
    		•  9.1839236553858 bayes_pls_golite062009
  • serine C-palmitoyltransferase activity
    		•  9.1839236553858 bayes_pls_golite062009
  • C-acyltransferase activity
    		•  4.29379571948906 bayes_pls_golite062009
  • L-aspartate:2-oxoglutarate aminotransferase activity
    		•  3.359406422625 bayes_pls_golite062009
  • 5-aminolevulinate synthase activity
    		•  3.15163480353521 bayes_pls_golite062009
  • catalytic activity
    		•  2.29878871754893 bayes_pls_golite062009
  • N-succinyltransferase activity
    		•  1.81799375593294 bayes_pls_golite062009
  • threonine aldolase activity
    		•  1.80396420390785 bayes_pls_golite062009
  • adenosylmethionine-8-amino-7-oxononanoate transaminase activity
    		•  1.74778109525713 bayes_pls_golite062009
  • glycine dehydrogenase (decarboxylating) activity
    		•  1.46601963907552 bayes_pls_golite062009
  • oxidoreductase activity, acting on the CH-NH2 group of donors, disulfide as acceptor
    		•  1.46601963907552 bayes_pls_golite062009
  • transferase activity, transferring nitrogenous groups
    		•  1.28316822767388 bayes_pls_golite062009
  • transaminase activity
    		•  1.24990480711889 bayes_pls_golite062009
  • transferase activity, transferring acyl groups
    		•  1.19150094103499 bayes_pls_golite062009
  • glycine C-acetyltransferase activity
    		•  0.935794708043259 bayes_pls_golite062009
  • transferase activity
    		•  0.737426388870721 bayes_pls_golite062009
  • carbon-sulfur lyase activity
    		•  0.698312655247044 bayes_pls_golite062009
  • intramolecular transferase activity, transferring amino groups
    		•  0.659071155545801 bayes_pls_golite062009
  • cystathionine beta-lyase activity
    		•  0.15938456446406 bayes_pls_golite062009
  • sulfurtransferase activity
    		•  0.0450490929307473 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.92

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle