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Protein Overview: Upf3-PB, FBpp0309967

General Information:
Name(s) found: FBpp0309967 [FlyBase]
Upf3-PB / FBpp0072130 [FlyBase]
Description(s) found:
Found 25 descriptions.
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  • type=protein; loc=2R:complement(19780699..19780941,19780998..19782140,19782198..19782290); ID=FBpp0309967; name=Upf3-PD; parent=FBgn0034923,FBtr0343302; dbxref=FlyBase:FBpp0309967,FlyBase_Annotation_IDs:CG11184-PD; MD5=7e086a07947f6f1bd54944841ea13b7c; length=492; release=r5.56; species=Dmel; [FlyBase]
  • The gene Upf3 is referred to in FlyBase by the symbol Dmel\Upf3 (CG11184, FBgn0034923). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 2R:19780589..19782510. It has the cytological map location 60A8-60A9. An electronic pipeline based on InterPro domains suggests that it has the molecular function</span>: nucleotide binding. There is experimental evidence that it is involved in the biological process</span>: nuclear-transcribed mRNA catabolic process, nonsense-mediated decay. 3 alleles are reported. No phenotypic data is available. It has one annotated transcript and one annotated polypeptide. [FlyBase]
    • Organism: Drosophila melanogaster
    Length: 492 amino acids

    Gene Ontology:
    Cellular Component: NONE FOUND
    Biological Process: nuclear-transcribed mRNA catabolic process, nonsense-mediated decay [IMP]
    [NOT]gene silencing by miRNA [IMP]
    [NOT]RNA interference [IMP]
    Molecular Function: nucleotide binding [IEA]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MAETFAEEKP KEKSKASRRK DKKDKTNQIV KIVMRHLPPT MTEAQFLDQV GPLPENDSYY  60
   61 YCKADWSLGQ EATCRAYIDM SSKDIGEVVQ FRDRFDGYVF VDHKGVEYMA IVEYAPFQCF 120
  121 LKNKARNDDS KVNTIESEPH YQEFIKRLAQ EREEASRMGD VKIDFNFERR TEEKVKSTPL 180
  181 LQYLANKKEK RREEARRRNE EKRKQREEQK LLRLAAQSDA SKLKEAEGGG GGGDTKKPAK 240
  241 KDVKDPQSSG SQANDAKASR SKRRTERDQR RREEHEQRKL VKRDKKKDDG QGKQDKQDKQ 300
  301 DKGKPSSGKQ NKNSKSMDIV ILKKANKPES NESLDVPSTS NAAEASKEKP ATENTETPEA 360
  361 AVKVFTPAAR GGRKEKRTGA DKQPAGSAHE TAEEAIKAAQ FRASEERRIR NKDRPSIAIY 420
  421 QPKARIRASD ELPQGAGGKD GSDGEASVVE EKTSKRNKRP NRRNKPKPKE VKECELETRR 480
  481 FSKSSESSTS VK

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    SHOWING SINGLE HITS. [ Hide Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


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    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..101] PSI-BLAST 28.0 The structural basis of the interaction between nonsense mediated decay factors UPF2 and UPF3
    2 View Details [102..492] PSI-BLAST 13.69897 Heavy meromyosin subfragment

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • RNA binding
    		•  3.75748736237159 bayes_pls_golite062009
  • mRNA binding
    		•  2.67679675039933 bayes_pls_golite062009
  • nucleic acid binding
    		•  2.39584426231036 bayes_pls_golite062009
  • binding
    		•  1.71154446874967 bayes_pls_golite062009
  • single-stranded RNA binding
    		•  0.61170301639809 bayes_pls_golite062009
    		• 0.24850555804347 bayes_pls_golite062009
  • hydrolase activity
    		•  0.0430264134452161 bayes_pls_golite062009
    2 No functions predicted.


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle