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Protein Overview: a-PC, a-PA, a-PB

General Information:
Name(s) found: a-PC / FBpp0099961 [FlyBase]
a-PB / FBpp0071678 [FlyBase]
a-PA / FBpp0071677 [FlyBase]
Description(s) found:
Found 50 descriptions.
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  • The gene arc is referred to in FlyBase by the symbol Dmel\a (CG6741, FBgn0000008). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 2R:18024494..18060346. It has the cytological map location 58C1-58C5. An electronic pipeline based on InterPro domains suggests that it has the molecular function</span>: protein binding. There is experimental evidence that it is involved in the biological process</span>: compound eye development. 35 alleles are reported. The phenotypes of these alleles are annotated with: ommatidium; crossvein; macrochaeta; eye; posterior scutellar bristle; wing. It has 3 annotated transcripts and 3 annotated polypeptides. [FlyBase]
  • The gene arc is referred to in FlyBase by the symbol Dmel\a (CG6741, FBgn0000008). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 2R:18024494..18060346. It has the cytological map location 58C1-58C5. An electronic pipeline based on InterPro domains suggests that it has the molecular function</span>: protein binding. There is experimental evidence that it is involved in the biological process</span>: compound eye development. 35 alleles are reported. The phenotypes of these alleles are annotated with: ommatidium; crossvein; macrochaeta; eye; posterior scutellar bristle; wing. It has 3 annotated transcripts and 3 annotated polypeptides. [FlyBase]
  • The gene arc is referred to in FlyBase by the symbol Dmel\a (CG6741, FBgn0000008). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 2R:18024494..18060346. It has the cytological map location 58C1-58C5. An electronic pipeline based on InterPro domains suggests that it has the molecular function</span>: protein binding. There is experimental evidence that it is involved in the biological process</span>: compound eye development. 35 alleles are reported. The phenotypes of these alleles are annotated with: ommatidium; crossvein; macrochaeta; eye; posterior scutellar bristle; wing. It has 3 annotated transcripts and 3 annotated polypeptides. [FlyBase]
    • Organism: Drosophila melanogaster
    Length: 1329 amino acids

    Gene Ontology:
    Cellular Component: adherens junction [IDA][NAS]
    apical plasma membrane [IDA]
    Biological Process: compound eye development [IMP]
    Molecular Function: protein binding [IEA]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MRLFKTRKST DTYSTLAAQQ QQQQQQQQQH QAEGSNISHS SNSSSNKSHT PATCSNRLNK  60
   61 SIVSSTSISS SLPDLHDKSP VMILSCTTLA SNGATATAAV TATATGTAAT SGGSLQQQQQ 120
  121 QHLQHQQQQQ PLRTATPTCL LSGRQTPSAI SVMSLQEATS LHRQQQQPHQ PPTIYVPVPT 180
  181 KLGNNVNTGN SSATLLLSYG STSSIANLQQ QQQQHAAQYQ QYVAQRLHAA SSSCLYEKGS 240
  241 NASGGASSNK SSLSLTPNGH LPDYKLVTAM PVVVLDDEHK SNSLPATEAS RNSNSSSNMN 300
  301 GSSNSNSLDV SNSNSHSGSS TSLASTTRNV FTWGKRMSRK LDLLKRSDSP AAAHKSHSDL 360
  361 RSLFHSPTHH KSGSGGSSGP SSAKASASPT GGHQNSSGST TSTLKKCKSG PIETIKQRHQ 420
  421 QQQQQQQSVQ DVGTGQSQSA QSTPTHQFQA AARPQKALKN FFHRIGSTGM LNHRSHNLLK 480
  481 ASEAAQQATP AATTLYRSSS TSQLSSSSYV KCDDPTEGLN LQREQREQRL PRIASLKSSS 540
  541 CDDIAKVSSC LTASTSSGSA AGSLGSPPSS AAAGGGGTAN SGQHDPSRRG AFPYAFLRSR 600
  601 LSVLPEENHG NVPGHLKQQI QRQREQHQQH QRDLLQQEQT SSPLPQRRSP EQAMLNNVSR 660
  661 NDSITSKDWE PLYQRLSSCL SSNESGYDSD GGATGARLGN NLSISGGDTE SIASGTLKRN 720
  721 SLISLSSSEG VGMGMGMSLG LGAPSTRNSS ICSAPVSLGG YNYDYETETI RRRFRQVKLE 780
  781 RKCQEDYIGI VLSPKTVMTN SNEQQYRYLI VELEPYGMAQ KDGRLRLGDE IVNVNGKHLR 840
  841 GIQSFAEVQR LLSSFVDNCI DLVIAHDEVT TVTDFYTKIR IDGMSTQRHR LSYVQRTQST 900
  901 DSLSSMQSLQ LQQERIQGHN TEQEQEAQGE DQCDARSMAS VSTMPTPMPL MQHRRSSTPR 960
  961 HSLDVGAPEH ELLRRRARSS SGQRSLALTP TPLFASGSSS CSSSPNHRLL DNENDPANDT1020
 1021 DSYTPVYANR AASVCVASSL ADDEKWQLLA RKRCSEGSAL SATPNPQQFG QRTHYARNSI1080
 1081 NLANSHYRSL RFAHSRLSSS RLSLFMQAPP NSLTVGEGVA NTPSSTATTT TDLTNQQQQQ1140
 1141 QNQQQTHQSL YIKHSPKSVS LFSPNPYVNA SSSPASASTS AGAGSSLAPP AAALMHHRPS1200
 1201 LPVAKLTIRD EEMAEVIRAS MSEGSGRCTP KTITFFKGPG LKSLGFSIVG GRDSPKGNMG1260
 1261 IFVKTVFPSG QAADDGTLQA GDEIVEINGN SVQGMSHAET IGLFKNVREG TIVLKILRRK1320
 1321 LQKAKSMGC

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


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    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..239] deduced N/A No confident structure predictions are available.
    2 View Details [240..349] deduced N/A No confident structure predictions are available.
    3 View Details [350..538] MSA 2.135989 View MSA. No confident structure predictions are available.
    4 View Details [539..749] deduced N/A No confident structure predictions are available.
    5 View Details [750..895] PSI-BLAST 16.69897 Solution Structure of The First PDZ domain of Human Atrophin-1 Interacting Protein 1 (KIAA0705 protein)
    6 View Details [896..1110] deduced N/A No confident structure predictions are available.
    7 View Details [1111..1208] deduced N/A No confident structure predictions are available.
    8 View Details [1209..1329] PSI-BLAST 27.522879 The crystal structure of the 13th PDZ domain of MPDZ

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2 No functions predicted.
    3 No functions predicted.
    4 No functions predicted.
    5
    Term Confidence Notes
  • protein binding
    		•  2.3816879009135 bayes_pls_golite062009
  • binding
    		•  2.18285297573892 bayes_pls_golite062009
  • receptor binding
    		•  0.237609767198544 bayes_pls_golite062009
  • protein domain specific binding
    		•  0.16193472434519 bayes_pls_golite062009
    6 No functions predicted.
    7 No functions predicted.
    8 No functions predicted.


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.66

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle