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Protein Overview: Sara-PA

General Information:
Name(s) found: Sara-PA / FBpp0071564 [FlyBase]
Description(s) found:
Found 33 descriptions.
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  • The gene Smad anchor for receptor activation is referred to in FlyBase by the symbol Dmel\Sara (CG15667, FBgn0026369). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 2R:17369424..17374618. It has the cytological map location 57E6. It is reported to have molecular function</span>: transforming growth factor beta receptor binding. It is reported to be involved in the biological process</span>: transforming growth factor beta receptor signaling pathway; protein localization. 11 alleles are reported. The phenotypes of these alleles are annotated with: wing vein L5; posterior crossvein; dorsal mesothoracic disc; wing vein; triple row. It has 2 annotated transcripts and 2 annotated polypeptides. [FlyBase]
    • Organism: Drosophila melanogaster
    Length: 1343 amino acids

    Gene Ontology:
    Cellular Component: early endosome [IDA]
    Biological Process: transforming growth factor beta receptor signaling pathway [NAS]
    protein localization [NAS]
    Molecular Function: zinc ion binding [IEA]
    transforming growth factor beta receptor binding [NAS]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MDLVDIDQVL DNLELSIAAD EQLSRNAAAA AAAGANPGRF LGDGASASIS GVGAGAGVSG  60
   61 AAGVTPTPAS GKSFVGVSQV FNSLDDYREN VKSLQVDAQL PSYDWQTEAE HEDDIHKFSE 120
  121 QASKNNGQTI VSSSESLTTS SCSTFSSGPS PVSNGSHSEE LATPPEDEKT SEVQVEPKEQ 180
  181 DQQPEQVKHE DQHQDQAVPP PTQSKQTVEE LAVGLSSISI TASGTESQSL LPEEVTASSV 240
  241 LGQVLEELSE ESSPSREPET EMTNGIDVPL ANLPASVAEV PVPKEMEQPV QTEEEDVELP 300
  301 QEQHPRRSQP LTFCSTMDEI SDTELDSMLQ EMDADDNQAD DQQMPDDEKS CSASPVTEEE 360
  361 SVRILSDEQE TTSNDQMNVD NFSQASTVEF ADLKQPESTP VTAMGEDVAS SFSSTESDSL 420
  421 SGRKLDGEVE VDREHEDASL ATDALETQEQ RPQRPQTLNL NGCQAESSTP SQDENPEIQQ 480
  481 ETLQPTEVRE GAAGVGVIPG EDDEESPIYE AVGYSDPHAN LGKVPPIWVP DNMAGQCMQC 540
  541 QQKFTMIKRR HHCRACGKVL CSVCCSQRFR LEFATEPESR VCVQCYMILS ERQANGLNSE 600
  601 SAPGSALPPT PIRSPNPNNP MEYCSTIPPH RQVANSPGAP PPSVIVPVGV LKKTDGSSSN 660
  661 SSSSDGQKGQ RKRKSVMFSD GIAPGSELAS TMEQQWGESK HSRRGLSRSG SGAGQKPPTP 720
  721 ATEEPPRSID TSSTLGLVAQ LFRGSIPPSA AAATLSATET SAGRSSSQSQ AQTSPRRKAE 780
  781 SSRNRKLPPN GDAQGCYLPP EENGLPPICI SSKEGGEVDY KVVRNDGSLL DRLQNETLKF 840
  841 IIKNNFFVLV KIVNMSCCMN RWVLNFTTSG LHHMGSDELI ILLEIKQPKQ EEYVKGEVAI 900
  901 PKDLFQHLYE IYVEAEHARS GTHELAFTSP RNANFLGSRE HGGFIFIRPT YQCLQGVIVP 960
  961 DNPYLVGVLI HRHEVPWAKV LPLRLILRLG AQYRYYPCPL ISVRGRESVY GEIAQTIINF1020
 1021 LVDFRNYSYS LPAIRGLYIH MEDRQTTVII PKYRQQDVIK AINNASDHIL AFAGNFSKVA1080
 1081 DGHLVCMQNI NDDRSEMYSY STQAINIQGQ PRKITGASFF VLNEALKSSS GLSGKCSIVE1140
 1141 DGLMVQIMPA KMEEVRQALR NQNDIDIVCG PIDATDDQSE IVSIKWVDNN RDINVGVKSP1200
 1201 IDDQPMDGIS NMRVLKWASF NYSNTNYAIR LSDIYIIKCE DWYATNGGNC EEITRIAEQL1260
 1261 ARSASMALLP LLDLLAAAGI NKLGLRATLD QDNVGYEAGA RGSKLPPLYM NALDNHLIAT1320
 1321 LHGESSGIQE PIILELIFYI LNA

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


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    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..470] PSI-BLAST 4.045757 COLICIN IA
    2 View Details [471..607] FFAS03 3.54 Hrs
    3 View Details [608..690] deduced N/A No confident structure predictions are available.
    4 View Details [691..844] PSI-BLAST 3.522879 Structure of the full-length E. coli ParC subunit
    5 View Details [845..932] deduced N/A No confident structure predictions are available.
    6 View Details [933..1079] deduced N/A No confident structure predictions are available.
    7 View Details [1080..1196] deduced N/A No confident structure predictions are available.
    8 View Details [1197..1343] deduced N/A No confident structure predictions are available.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2
    Term Confidence Notes
  • binding
    		•  2.41213967358615 bayes_pls_golite062009
  • protein binding
    		•  1.32925779020231 bayes_pls_golite062009
  • transcription regulator activity
    		•  0.465878991370073 bayes_pls_golite062009
  • DNA binding
    		•  0.380632099574102 bayes_pls_golite062009
  • nucleic acid binding
    		•  0.270854881856333 bayes_pls_golite062009
    3 No functions predicted.
    4 No functions predicted.
    5 No functions predicted.
    6 No functions predicted.
    7 No functions predicted.
    8 No functions predicted.


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.77

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle