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Protein Overview: dom-PA

General Information:
Name(s) found: dom-PA / FBpp0071529 [FlyBase]
Description(s) found:
Found 19 descriptions.
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  • The gene domino is referred to in FlyBase by the symbol Dmel\dom (CG9696, FBgn0020306). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 2R:17210949..17229352. It has the cytological map location 57D11-57D12. There is experimental evidence that it has the molecular function</span>: protein binding. There is experimental evidence that it is involved in the biological process</span>: gene silencing; chromatin organization; negative regulation of gene expression; instar larval or pupal development; oogenesis; regulation of alternative nuclear mRNA splicing, via spliceosome. 27 alleles are reported. The phenotypes of these alleles are annotated with: plasmatocyte; imaginal ring; lymph gland; prohemocyte; embryonic/larval hemocyte; midgut imaginal island; hemocyte; wing; imaginal disc; adult neuroblast. It has 4 annotated transcripts and 4 annotated polypeptides. [FlyBase]
    • Organism: Drosophila melanogaster
    Length: 3198 amino acids

    Gene Ontology:
    Cellular Component: nucleus [IC][IDA]
    chromatin remodeling complex [ISS]
    Biological Process: cell proliferation [NAS]
    gene silencing [IGI]
    negative regulation of gene expression [IMP]
    oogenesis [IMP]
    regulation of alternative nuclear mRNA splicing, via spliceosome [IMP]
    hemopoiesis [TAS]
    negative regulation of hemocyte proliferation [TAS]
    chromatin organization [IMP]
    instar larval or pupal development [IMP]
    Molecular Function: DNA binding [IEA]
    ATP binding [IEA]
    DNA-dependent ATPase activity [ISS]
    protein binding [IPI]
    general RNA polymerase II transcription factor activity [ISS]
    helicase activity [IEA][NAS]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MNEGNSAGGG HEGLSPAPPA VPDRVTPHST EISVAPANST STTVRAAGSV GAALPATRHH  60
   61 QHIATQVKGI ASSSSKQQKQ LASAQLPVPL SPLPQQQQQT AEATAAAAAP AHSNVSVSSS 120
  121 TIEASVLPPQ AKRQRLDDNE DRTSAASIVG PAESSNIVSS LLPASVASSS EVGGLSSTAL 180
  181 QDLNALKKRI LQQKLQILRN LKERHLENVS EYFYLQNGGS MMDYPAWRKK TPTPQFISYS 240
  241 NANRIDQLIH EDKPSTSAAA AAAQNQKYTT QQTDSVESSL VSGIGTGATK GAPLDGNISN 300
  301 STVKTNTQSQ VPSKIGSFTE STPAATESNS STTVPGTATS GAATSTSATS AEASGNVLAV 360
  361 EAEIKIPAVG ATPVAISTKL PAAVVQLTQQ GGTPLLPCNT SAGSTALRRP QGQNNASSGS 420
  421 AAASGGGGSL TPTPLYTGNG PAALGGSGGL TPGTPTSGSL LSPALGGGSG TPNSAAQEFS 480
  481 FKAKQEVYVM QRISELQREG LWTERRLPKL QEPSRPKAHW DYLLEEMVWL AADFAQERKW 540
  541 KKNAAKKCAK MVQKYFQDKA TAAQRAEKAQ ELQLKRVASF IAREVKSFWS NVEKLVEYKH 600
  601 QTKIEEKRKQ ALDQHLSFIV DQTEKFSQQL VEGMNKSVAD TPSLNSSRLT SPKRESDDDF 660
  661 RPESGSEDDE ETIAKAEEDA ADVKEEVTAL AKESEMDFDD FLNDLPPGYL ENRDKLMKEE 720
  721 QSSAIKTETP DDSDDSEFEA KEASDDDENT ISKQEEAEQE IDHKKEIDEL EADNDLSVEQ 780
  781 LLAKYKSEQP PSPKRRKLAP RDPELDSDDD STAVDSTEES EDAATEDEED LSTVKTDTDM 840
  841 EEQDEQEDGL KSLMADADAT SGAAGSGSTA GASGNKDDML NDAAALAESL QPKGNTLSST 900
  901 NVVTPVPFLL KHSLREYQHI GLDWLVTMNE RKLNGILADE MGLGKTIQTI ALLAHLACAK 960
  961 GNWGPHLIVV PSSVMLNWEM EFKKWCPGFK ILTYYGSQKE RKLKRVGWTK PNAFHVCITS1020
 1021 YKLVVQDQQS FRRKKWKYLI LDEAQNIKNF KSQRWQLLLN FSTERRLLLT GTPLQNDLME1080
 1081 LWSLMHFLMP YVFSSHREFK EWFSNPMTGM IEGNMEYNET LITRLHKVIR PFLLRRLKKE1140
 1141 VEKQMPKKYE HVITCRLSNR QRYLYEDFMS RAKTRETLQT GNLLSVINVL MQLRKVCNHP1200
 1201 NMFEARPTIS PFQMDGITFH TPRLVCDIME YDPFTQINLE TLNLLLLHLE QTMTAYVSHK1260
 1261 SRLLAPPRKL IEDIDTAPLP APRCPNGKYR FHIRVRSAEL AQRIKLNAVK VGASPAMRLE1320
 1321 GSKIMPMRNL LPSGRVLKRV SASINPVNMA LKPVVINSVV TTTSSSTTAS SPTGALSVLS1380
 1381 NSKLLGARSQ INAPTPAKVA KTMQDGKPFF YLTPATNSGA AGARLTLTSK TTASASTTTS1440
 1441 RTTVTASTTS GQQLIRDPIV KDLATHVKST VQKQSIANGK TEPEEETEAE DPYKVQELIQ1500
 1501 MRKEQRLAAL KRMAMINRRR TDATPIYGED CREAIQRCMQ ATRSLKRSTW QTRGYANCCT1560
 1561 AMAHRNGWSL NHLLKSFEER CADLKPVFAN FVIYVPSVCA PRIRRYVQNL SSTHWQHEQR1620
 1621 IENIVDQALR PKLALLHPII SEMTTKFPDP RLIQYDCGKL QTMDRLLRQL KVNGHRVLIF1680
 1681 TQMTKMLDVL EAFLNYHGHI YLRLDGSTRV EQRQILMERF NGDKRIFCFI LSTRSGGVGI1740
 1741 NLTGADTVIF YDSDWNPTMD AQAQDRCHRI GQTRDVHIYR LVSERTIEVN ILKKANQKRM1800
 1801 LSDMAIEGGN FTTTYFKSST IKDLFTMEQS EQDESSQEKS ENKDRIVATT TLSDTPSTVV1860
 1861 ETEKQSLRAF EHALAAAEDE QDVQATKTAK AEVAADLAEF DENIPIATED PNAEGGPQVE1920
 1921 LSKADLEMQN LVKQLSPIER YAMRFVEETG AAWTAEQLRA AEAELEAQKR EWEANRLAAM1980
 1981 HKEEELLKQE TEAEEMLTYS RKDSSNQVWI SRNTMEQMPM WCPPTPPQDN DNDIYIDYSL2040
 2041 SFMYELEPIA ETDLPPVYVR KEHKRSRTDA GYDGSRRPNK MRREDNYVPP RSLFDRPTPQ2100
 2101 LARLRRELKS QRFRGSFKPN MPIPGLKPQL PTKPLTEPEA MAEWCVFEDM AILHVLVNLQ2160
 2161 GLPCSLMLLS PGQTPNWDLV SEMVNFCSKT YRSARQCRWR YETHIQPREE GKVVESPKKQ2220
 2221 KKLKPTLRTE YLKSPLRYLR TTQLYVSDNN ASFYKTMRSR FDSIKTAYLK KAPPPKRQFS2280
 2281 APSLMNPKHM EVLQEFGILN YDQPVSPQNI AAMKANKIRE KQRGQQMSQP PVGVGVVQQM2340
 2341 QQQSQQQQQP APPPLPQQQQ PQQVVQQVQQ QQQQQQQQQQ QQVVQQQLPT VSNVQQTLPV2400
 2401 QQTVELVQQQ PTTTTTVAVP AAGGQLQQLQ IQHLTSSNVS PGQQTAILLH QPQQQLRTHP2460
 2461 GQGGQSNTQQ LVKTIVGTSS SLTAGQLQQL AQQSAVASGG QSSVSVVLTT PVQTLPSVVQ2520
 2521 PQIGSGAQIV SISSQTLPVN SSPQLGSIVQ TQSLPQVVSV STLPTVGTVL TTTANQPQQQ2580
 2581 HQTTAVTTLN TTMLRGQRIV STAAGNTLQQ RTTAGGQSIV SMPNLGQGAS PSQFQTQLRL2640
 2641 AAVPTSPATQ TTQLVTTKGI PVSALQQGGK TTVIPVTQQS GGAHIQLYRQ RSLKVLQTTT2700
 2701 QAVPSGSAGA TGATANLVQA GGTIIQASNM ATHVTSQKVA VSGMPGTSTT VQAGNVVSSV2760
 2761 QMHGQARTQF IKQMAAGKQQ LQRQVVSADG TTTTTAAGDM LLVKRHNILA AQKAQQASGA2820
 2821 LFTTTTGQQQ QQQQQQGQLP VAGQPQQVTQ HQIASLVKAS TAAAASGSSV NAGGVTVSAT2880
 2881 NPTVQAGSVN MTLPQLKPGS QIKVTMPNQM RHLQMQQQLT MPRKISRMTQ LVSASGQPTA2940
 2941 TNIITTTGPQ QQQQGVTVSG GGTLPTVASQ QQQQQHQQKV GGGNSVQAQL LHIQNTKGLS3000
 3001 NSVTMQQIQQ VMRSGQQGTL ATTNLVLGKT SVGRVIPVSV ASQANQRQTI QVVSAASAQA3060
 3061 LAAGNLRTHV AGPSIASTLK VAAPGSAGGQ TTQQTLIAAL QHNQRQNASP VRLQTTAGGN3120
 3121 LLAVVQQQQQ QQHTSIAGPT AGPAEVMTIT QTTTTLPTVG SLQQQQQQQQ QQGGISQPTT3180
 3181 QQVRKLVQKK ILIRSEKE

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data



    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.97

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle