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Protein Overview: Pu-PA

General Information:
Name(s) found: Pu-PA / FBpp0071507 [FlyBase]
Description(s) found:
Found 26 descriptions.
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  • The gene Punch is referred to in FlyBase by the symbol Dmel\Pu (CG9441, FBgn0003162). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 2R:17062822..17070121. It has the cytological map location 57C7-57C8. There is experimental evidence that it has the molecular function</span>: GTP cyclohydrolase activity; GTP cyclohydrolase I activity. There is experimental evidence that it is involved in the biological process</span>: preblastoderm mitotic cell cycle; cuticle pigmentation; pteridine biosynthetic process; embryonic pattern specification; compound eye pigmentation; larval chitin-based cuticle development. 80 alleles are reported. The phenotypes of these alleles are annotated with 11 unique terms, many of which group under: organ system; peripheral nervous system; cuticle; nervous system; external compound sense organ; adult segment; extended germ band embryo; adult mesothoracic segment; blastoderm embryo; compound cell cluster organ; acellular anatomical structure; thoracic segment; cephalopharyngeal skeleton. It has 3 annotated transcripts and 3 annotated polypeptides. [FlyBase]
    • Organism: Drosophila melanogaster
    Length: 324 amino acids

    Gene Ontology:
    Cellular Component: cytoplasm [IDA]
    Biological Process: cuticle pigmentation [IMP]
    tetrahydrobiopterin biosynthetic process [NAS]
    larval chitin-based cuticle development [IMP]
    embryonic pattern specification [IMP]
    preblastoderm mitotic cell cycle [IMP]
    pteridine biosynthetic process [IMP]
    tetrahydrofolate biosynthetic process [IEA]
    compound eye pigmentation [IMP]
    Molecular Function: GTP cyclohydrolase activity [IDA]
    GTP cyclohydrolase I activity [IDA][ISS][NAS]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSFTRQLSEM SASELNDAID DTNFPQAHIL SRGRNNSVCS TSSTSGTSSL ADRQQNQAEE  60
   61 ATAIAGTPVE EVAPAPALVP LAGNQRPRLI LKTNGSSPDS DGTQPKTPLT PRTSTTPGHE 120
  121 KCTFHHDLEL DHKPPTREAL LPDMARSYRL LLGGLGENPD RQGLIKTPER AAKAMLYFTK 180
  181 GYDQSLEDVL NGAVFDEDHD EMVVVKDIEM FSMCEHHLVP FYGKVSIGYL PCNKILGLSK 240
  241 LARIVEIFSR RLQVQERLTK QIAVAVTQAV QPAGVAVVVE GVHMCMVMRG VQKINSKTVT 300
  301 STMLGVFRDD PKTREEFLNL VNSK

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


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    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..71] deduced N/A No confident structure predictions are available.
    2 View Details [72..324] PSI-BLAST 90.39794 GTP cyclohydrolase I


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.94

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle