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Protein Overview: sm-PE, sm-PA

General Information:
Name(s) found: sm-PE / FBpp0099612 [FlyBase]
sm-PA / FBpp0085681 [FlyBase]
Description(s) found:
Found 41 descriptions.
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  • The gene smooth is referred to in FlyBase by the symbol Dmel\sm (CG9218, FBgn0003435). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 2R:15417414..15519007. It has the cytological map location 56D15-56E1. Based on sequence similarity, it is predicted to have molecular function</span>: mRNA binding. There is experimental evidence that it is involved in the biological process</span>: axon guidance; adult feeding behavior. 21 alleles are reported. The phenotypes of these alleles are annotated with: macrochaeta; abdominal sternite bristle; acrostichal bristle; scutellar bristle; microchaeta. It has 6 annotated transcripts and 6 annotated polypeptides. [FlyBase]
  • The gene smooth is referred to in FlyBase by the symbol Dmel\sm (CG9218, FBgn0003435). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 2R:15417414..15519007. It has the cytological map location 56D15-56E1. Based on sequence similarity, it is predicted to have molecular function</span>: mRNA binding. There is experimental evidence that it is involved in the biological process</span>: axon guidance; adult feeding behavior. 21 alleles are reported. The phenotypes of these alleles are annotated with: macrochaeta; abdominal sternite bristle; acrostichal bristle; scutellar bristle; microchaeta. It has 6 annotated transcripts and 6 annotated polypeptides. [FlyBase]
    • Organism: Drosophila melanogaster
    Length: 475 amino acids

    Gene Ontology:
    Cellular Component: nucleus [IEA]
    ribonucleoprotein complex [NAS]
    Biological Process: axon guidance [IMP]
    mRNA processing [IEA]
    adult feeding behavior [IMP]
    Molecular Function: nucleotide binding [IEA]
    RNA binding [IEA]
    mRNA binding [ISS]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MPYNGASNGS GASGAGGGGA TIVVTEGPQN KKIRTGVQQP GENDVHMHAR STPQQNQQQA  60
   61 LMNKSNDDLR RKRPETTRPN HILLFTIINP FYPITVDVLH KICHPHGQVL RIVIFKKNGV 120
  121 QAMVEFDNLD AATRARENLN GADIYAGCCT LKIDYAKPEK LNVYKNEPDT SWDYTLSTEP 180
  181 PLLGPGAAFP PFGAPEYHTT TPENWKGAAI HPTGLMKEPA GVVPGRNAPV AFTPQGQAQG 240
  241 AVMMVYGLDH DTSNTDKLFN LVCLYGNVAR IKFLKTKEGT AMVQMGDAVA VERCVQHLNN 300
  301 IPVGTGGKIQ IAFSKQNFLS EVINPFLLPD HSPSFKEYTG SKNNRFLSPA QASKNRIQPP 360
  361 SKILHFFNTP PGLTEDQLIG IFNIKDVPAT SVRLFPLKTE RSSSGLIEFS NISQAVLAIM 420
  421 KCNHLPIEGK GTKFPFIMKL CFSSSKSMNG AWNNAASEGM IEKENEVDTK VDIYN

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..220] PSI-BLAST 11.69897 No description for 2e5iA was found.
    2 View Details [221..475] PSI-BLAST 30.0 Solution structure of Polypyrimidine Tract Binding protein RBD34 complexed with CUCUCU RNA

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2
    Term Confidence Notes
  • RNA binding
    		•  6.73097473547076 bayes_pls_golite062009
  • mRNA binding
    		•  5.29759606920196 bayes_pls_golite062009
    		• 4.67888641618755 bayes_pls_golite062009
  • nucleic acid binding
    		•  3.81920018903278 bayes_pls_golite062009
  • binding
    		•  3.49612884560266 bayes_pls_golite062009
  • poly-pyrimidine tract binding
    		•  3.11990160533699 bayes_pls_golite062009
  • single-stranded RNA binding
    		•  2.93798024346416 bayes_pls_golite062009
  • snRNA binding
    		•  1.76821382294389 bayes_pls_golite062009
  • structural molecule activity
    		•  1.29928829870122 bayes_pls_golite062009
  • protein binding
    		•  1.14508556628804 bayes_pls_golite062009
  • transcription regulator activity
    		•  1.07788694919471 bayes_pls_golite062009
  • DNA binding
    		•  0.978604858165557 bayes_pls_golite062009
  • U1 snRNA binding
    		•  0.612226940931031 bayes_pls_golite062009
  • mRNA 3'-UTR binding
    		•  0.591700155096213 bayes_pls_golite062009
  • transcription factor activity
    		•  0.234742017105535 bayes_pls_golite062009
  • transporter activity
    		•  0.00947930769815086 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.91

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle