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Protein Overview: cora-PA

General Information:
Name(s) found: cora-PA / FBpp0085697 [FlyBase]
Description(s) found:
Found 21 descriptions.
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  • The gene coracle is referred to in FlyBase by the symbol Dmel\cora (CG11949, FBgn0010434). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 2R:15116570..15131256. It has the cytological map location 56C4. Based on sequence similarity, it is predicted to have molecular function</span>: cytoskeletal protein binding. There is experimental evidence that it is involved in the biological process</span>: embryonic morphogenesis; maintenance of imaginal disc-derived wing hair orientation; regulation of tube size, open tracheal system; establishment of glial blood-brain barrier. 42 alleles are reported. The phenotypes of these alleles are annotated with 18 unique terms, many of which group under: peripheral nervous system; organ system; nervous system; external compound sense organ; plasma membrane part; integumentary plate; plasma membrane; embryonic head; embryonic dorsal trunk; wing hair; embryonic tracheal system. It has 4 annotated transcripts and 4 annotated polypeptides. [FlyBase]
    • Organism: Drosophila melanogaster
    Length: 1698 amino acids

    Gene Ontology:
    Cellular Component: apicolateral plasma membrane [NAS]
    cytoskeleton [ISS]
    septate junction [IDA][NAS][TAS]
    [NOT]fusome [IDA]
    [NOT]spectrosome [IDA]
    Biological Process: dorsal closure [NAS][TAS]
    embryonic development [NAS]
    maintenance of imaginal disc-derived wing hair orientation [IMP]
    cytoskeleton organization [ISS]
    regulation of tube size, open tracheal system [IMP]
    chitin-based embryonic cuticle biosynthetic process [TAS]
    establishment or maintenance of cell polarity [NAS]
    establishment of glial blood-brain barrier [IMP]
    protein targeting to membrane [TAS]
    cell-cell junction organization [TAS]
    salivary gland morphogenesis [TAS]
    embryonic morphogenesis [IMP]
    septate junction assembly [TAS]
    Molecular Function: actin binding [IEA]
    structural molecule activity [IEA]
    cytoskeletal protein binding [ISS]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MPAEIKPSAP AEPETPTKSK PKSSSSSHGK PALARVTLLD GSLLDVSIDR KAIGRDVINS  60
   61 ICAGLNLIEK DYFGLTYETP TDPRTWLDLE KPVSKFFRTD TWPLTFAVKF YPPEPSQLKE 120
  121 DITRYHLCLQ VRNDILEGRL PCTFVTHALL GSYLVQSEMG DYDAEEMPTR AYLKDFKIAP 180
  181 NQTAELEDKV MDLHKTHKGQ SPAEAELHYL ENAKKLAMYG VDLHPAKDSE GVDIMLGVCA 240
  241 SGLLVYRDKL RINRFAWPKI LKISYKRHHF YIKIRPGEFE QYESTIGFKL ANHRAAKKLW 300
  301 KSCVEHHTFF RLMTPEPVSK SKMFPVFGST YRYKGRTQAE STNTPVDRTP PKFNRTLSGA 360
  361 RLTSRSMDAL ALAEKEKVAR KSSTLDHRGD RNADGDAHSR SPIKNKKEKD ADKEAKLREK 420
  421 KQKEKEEKER KEREKRELEE KKKAEKAAKA ALAAGAAAGA AVNGNDELND SNKSDKSSGR 480
  481 RGVGIFSSGR KSKSGSPSKD GKDKSGKDKD KEVGRLGLVV TSGLGDNQQD QNLDEAARNA 540
  541 AKNRGSTTPG VTRQYEYAVD NDGNTSPTRK SYTPGGFRYD QDPNSRKSGA DGQEQLSPTS 600
  601 QQKKIGLAFN YAPGNENALK ETAEKLKAGQ LSPRTQDKLN RGQLSPKSRA KLLQDPLLSP 660
  661 TTRAKLQGSA VDAAAVPLSD SQKRSYSPTK GPQGYSSGAP GSYKPISDPT ADFLESQRYN 720
  721 KEPGYVGPSK ADVAAGLAGA AGSKKPGSPT KTGKGAPGAA AAAAAGAAGA AAAAAKPKKR 780
  781 RVKIMVITSK FDPSTKRIDA ENGSIEHSTG ILDPATGLID TKYGVIDPKK GTLEALNTKT 840
  841 GKKEVFQGDV DGKTGNLHLV SGVADPKTGR LDDTLGQIVC ITPQDNPVVE LTVITSRIDP 900
  901 ATGKIDTVNG DVERSLGVLN LDTGLLDTKY GEINTRTGEL KAIDPKSGKI VVSKNVKVDP 960
  961 GTGQITILGI VDPKTNKIDP NQGRLIEVGQ QIDPIVEVTS LAGKFDSKRN IIDPKTAQVE1020
 1021 TSGGQFDPKA GKIDTKYGQI DLVKHTITFN DPKSGKTVTR DIKIEPTTGQ IVLKNQVNPK1080
 1081 NNKPDKDYAR IISLRIVQQR VDPATKAPIT EVSASKDKDI VVDPKSNQIW VPTGATDPAT1140
 1141 KEQQYISSSV DPKTGYVITI YGYLDPKTNE IKKQTKLDPN TIKIEPTSGK IYTATGEVDQ1200
 1201 ATGEPLYAAT QVDPESGEVY TKLARVDPKT GKIVIVRILL ISKTDERGRP EEIDPSTCEI1260
 1261 DPVSGRVLKF FNKTVYVYNM IDPVTGEIVQ VDPNDPRFAG ARTTVTHTMT LTGEIDPVTG1320
 1321 RIKSEYGDID PNTGDIDPAT AVTDPVTGKL ILNYAQIDPS HFGKQAQVQT TTETVPITRQ1380
 1381 QFFDGVKHIS KGALRRDSEG SSDDDMTAQY GADQVNEILI GSPAGQAGGK LGKPVSTPTV1440
 1441 VKTTTKQVLT KNIDGVTHNV EEEVRNLGTG EVTYSTQEHK ADATPTDLSG AYVTATAVTT1500
 1501 RTATTHEDLG KNAKTEQLEE KTVATTRTHD PNKQQQRVVT QEVKTTATVT SGDQYQRRDS1560
 1561 VSSTSSGDSG TPIDGPYDGA SVVRTDNQKS PLFTTSATTG PHVESTRVVL GEDTPGFSGH1620
 1621 GEIISTQTVS SKTRTVETIT YKTERDGIVE TRVEQKITIQ SDGDPIDHDK ALAEAIQEAT1680
 1681 AMNPDMTVEK IEIQQQTQ

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


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    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..313] PSI-BLAST 127.0 No description for 2he7A was found.
    2 View Details [314..371] deduced N/A No confident structure predictions are available.
    3 View Details [372..590] deduced N/A No confident structure predictions are available.
    4 View Details [591..695] deduced N/A No confident structure predictions are available.
    5 View Details [696..773] deduced N/A No confident structure predictions are available.
    6 View Details [774..880] deduced N/A No confident structure predictions are available.
    7 View Details [881..944] deduced N/A No confident structure predictions are available.
    8 View Details [945..1007] deduced N/A No confident structure predictions are available.
    9 View Details [1008..1102] deduced N/A No confident structure predictions are available.
    10 View Details [1103..1186] deduced N/A No confident structure predictions are available.
    11 View Details [1187..1342] MSA 2.275997 View MSA. No confident structure predictions are available.
    12 View Details [1343..1398] deduced N/A No confident structure predictions are available.
    13 View Details [1399..1620] deduced N/A No confident structure predictions are available.
    14 View Details [1621..1698] Pfam 21.200659 No description for PF05902.4 was found. No confident structure predictions are available.


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle