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Protein Overview: CG6385-PA

General Information:
Name(s) found: CG6385-PA / FBpp0088528 [FlyBase]
Description(s) found:
Found 19 descriptions.
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  • This gene is referred to in FlyBase by the symbol Dmel\CG6385 (CG6385, FBgn0034276). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 2R:13641052..13643923. It has the cytological map location 54E8. Based on sequence similarity, it is predicted to have molecular function</span>: sarcosine dehydrogenase activity. An electronic pipeline based on InterPro domains suggests that it is involved in the biological process</span>: glycine catabolic process. 2 alleles are reported. No phenotypic data is available. It has one annotated transcript and one annotated polypeptide. [FlyBase]
    • Organism: Drosophila melanogaster
    Length: 894 amino acids

    Gene Ontology:
    Cellular Component: cytoplasm [IEA]
    Biological Process: glycine catabolic process [IEA]
    Molecular Function: sarcosine dehydrogenase activity [ISS]
    aminomethyltransferase activity [IEA]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MWRHRILQQA SRRGISKQVR EDGGARREPS GFLPGAADVV VIGGGSAGCH TLYHLARRGV  60
   61 KAVLLERAQL TAGTTWHTAG LLWRLRPNDV DIQLLANSRR MLQQLEEETE LDPGWIQNGG 120
  121 IFIAHNETRL DEYRRLATVG SALGIENQVL SPEDTQKLFP LLDPSAFVGA LYSPGDGVMD 180
  181 PAMLCAALKK AATNLGAQVI ENCGVDDLLL EQTARGKKVV GVSTPFGDIK AEKVVNATGV 240
  241 WGRDLVARHG THLPLVPMKH AYIVSESIPG VRGLPNIRDH DYSTYFRIQG DAICMGGYEP 300
  301 NPILLEPVPK DFHFGLYELD WSVFETHVEG AQKLCPSYAK YGVKSTVCGP ESFTPDHKPL 360
  361 MGPDPNLDGL YHNCGFNSAG MMFGGGCGEQ TALWVIQGQP DLPMFGFDLR RFTQEQGKAI 420
  421 QWIREKSHES YVKNYSMVFK YDQPLAGRDF QKDPLHDEMM KAGAVMEEKQ GWERPGFFLP 480
  481 TGSKKAVVQP YDWYGSYVHQ RHKDSEYERV LDGDLHYSRF SEYHDLIGSE ALACRNNAVV 540
  541 FNMSYFAKLL LDGPQAQEAA DWLFSANTNR DPSKTVYTCA LNDAGGVEAD VTISRLAPGS 600
  601 GEVYNPKING QGFYIVAGGA SAFYTYSVLL AEIRRKGFNA SLKDLTAELG VISIQGPNSR 660
  661 KILQPLIDCD LSDEHVAPNS TRLAKFGDVG LRLLRVSFVG ELGYELHVPK KDCAAVYRSL 720
  721 MKAGAGEDLR NAGYRSLYSL SSEKGYHLWS FDLRPDDTPL EAGLGFTCRK TGADYRGKAA 780
  781 IENQRAEGLK KRLVYLTLRD QVPIWGLEGV YRNGEPVGIL RRAEYAYTLG KSLGQTYVSR 840
  841 PDGKIIDADY IRNGEYEVDI LGKKYRADCH LRSPFDPTGQ RVLGNYASES KSNK

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    SHOWING SINGLE HITS. [ Hide Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..894] PSI-BLAST 153.0 Crystal structure of dimethylglycine oxidase of Arthrobacter globiformis in complex with acetate

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • aminomethyltransferase activity
    		•  10.5654741349554 bayes_pls_golite062009
  • glycine dehydrogenase (decarboxylating) activity
    		•  5.37200252580633 bayes_pls_golite062009
  • oxidoreductase activity, acting on the CH-NH2 group of donors, disulfide as acceptor
    		•  5.37200252580633 bayes_pls_golite062009
  • oxidoreductase activity, acting on the CH-NH2 group of donors
    		•  5.05753119769143 bayes_pls_golite062009
  • sarcosine dehydrogenase activity
    		•  3.16989177210403 bayes_pls_golite062009
  • dimethylglycine dehydrogenase activity
    		•  2.89047185292175 bayes_pls_golite062009
  • choline dehydrogenase activity
    		•  2.71076524649484 bayes_pls_golite062009
  • methyltransferase activity
    		•  2.70138650934058 bayes_pls_golite062009
  • transferase activity, transferring one-carbon groups
    		•  2.61988251128991 bayes_pls_golite062009
  • oxidoreductase activity
    		•  2.3417445147889 bayes_pls_golite062009
  • oxidoreductase activity, acting on sulfur group of donors, NAD or NADP as acceptor
    		•  1.61125987248836 bayes_pls_golite062009
  • oxidoreductase activity, acting on sulfur group of donors
    		•  1.48681373014973 bayes_pls_golite062009
  • dihydrolipoyl dehydrogenase activity
    		•  1.24564487540873 bayes_pls_golite062009
  • catalytic activity
    		•  1.03127962968326 bayes_pls_golite062009
  • oxidoreductase activity, acting on the CH-NH group of donors
    		•  0.442625746935807 bayes_pls_golite062009
  • transferase activity
    		•  0.217873555384951 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.81

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle