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Protein Overview: Got1-PA

General Information:
Name(s) found: Got1-PA / FBpp0086371 [FlyBase]
Description(s) found:
Found 22 descriptions.
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  • The gene Glutamate oxaloacetate transaminase 1 is referred to in FlyBase by the symbol Dmel\Got1 (CG8430, FBgn0001124). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 2R:12025857..12029439. It has the cytological map location 52E7-52E10. There is experimental evidence that it has the molecular function</span>: L-aspartate:2-oxoglutarate aminotransferase activity. There is experimental evidence that it is involved in the biological process</span>: glutamate biosynthetic process. 7 alleles are reported. No phenotypic data is available. It has 2 annotated transcripts and 2 annotated polypeptides. [FlyBase]
    • Organism: Drosophila melanogaster
    Length: 416 amino acids

    Gene Ontology:
    Cellular Component: mitochondrial matrix [ISS]
    Biological Process: glutamate biosynthetic process [IDA]
    aspartate metabolic process [ISS]
    Molecular Function: pyridoxal phosphate binding [IEA]
    L-aspartate:2-oxoglutarate aminotransferase activity [IDA][ISS]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSIYADVPKG PAIEVFALTQ AFKDDSNPNK VNLSVGAYRT DAGVPWVLPV VRKTEISIAS  60
   61 DEQVNHEYLP VTGLETFTNA ATELVLGADS PAIKENRAFG VQTISGTGAL RVAADFLHTQ 120
  121 LNRNVVYYSN PTWENHHKIF CDAGFTTVKS YRYWDQNKRE LDFKNMLADL NDAPPGAVII 180
  181 LHACAHNPTG IDPTQEQWTE LADLMEKKKL FPLFDSAYQG FASGDPDRDA WAARYFVQRG 240
  241 FELFICQSFA KNFGLYCERT GNLAVVQKNG ATKAAVHSQL TLLIRGQYSN PPAYGARIVS 300
  301 KVLNTPELRK EWMASIQAMS SRIREMRTAL RDKLVALGTP GTWDHIVNQI GMFSYTGLNE 360
  361 SHVRVLIDQY HIYLLKTGRI SMSGLNKGNV EYVAKAIHAA VTGSGESASC PCENKL

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..416] PSI-BLAST 85.221849 OXOGLUTARATE-INDUCED CONFORMATIONAL CHANGES IN CYTOSOLIC ASPARTATE AMINOTRANSFERASE

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • L-aspartate:2-oxoglutarate aminotransferase activity
    		•  6.52158261185762 bayes_pls_golite062009
  • phosphatidylserine decarboxylase activity
    		•  3.52333113038086 bayes_pls_golite062009
  • catalytic activity
    		•  2.29878871754893 bayes_pls_golite062009
  • glycine dehydrogenase (decarboxylating) activity
    		•  1.46601963907552 bayes_pls_golite062009
  • oxidoreductase activity, acting on the CH-NH2 group of donors, disulfide as acceptor
    		•  1.46601963907552 bayes_pls_golite062009
  • transferase activity
    		•  1.44093490824786 bayes_pls_golite062009
  • glutamate decarboxylase activity
    		•  1.34215658716536 bayes_pls_golite062009
  • transferase activity, transferring nitrogenous groups
    		•  1.28316822767388 bayes_pls_golite062009
  • transaminase activity
    		•  1.24990480711889 bayes_pls_golite062009
  • 4-aminobutyrate transaminase activity
    		•  1.11017195698597 bayes_pls_golite062009
  • transcription regulator activity
    		•  0.977210827616757 bayes_pls_golite062009
  • nucleic acid binding
    		•  0.892872530648552 bayes_pls_golite062009
  • binding
    		•  0.892049641082766 bayes_pls_golite062009
  • N-succinyltransferase activity
    		•  0.87264568471543 bayes_pls_golite062009
  • DNA binding
    		•  0.803965264969424 bayes_pls_golite062009
  • N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
    		•  0.753443687983955 bayes_pls_golite062009
  • vitamin binding
    		•  0.66463470119531 bayes_pls_golite062009
  • transcription factor activity
    		•  0.597417107954964 bayes_pls_golite062009
  • transferase activity, transferring acyl groups
    		•  0.50269055590758 bayes_pls_golite062009
  • alanine-glyoxylate transaminase activity
    		•  0.48682493494502 bayes_pls_golite062009
  • hydrolase activity
    		•  0.343938599116946 bayes_pls_golite062009
  • vitamin B6 binding
    		•  0.16957228630576 bayes_pls_golite062009
  • pyridoxal phosphate binding
    		•  0.16957228630576 bayes_pls_golite062009
  • ligase activity
    		•  0.103307018783573 bayes_pls_golite062009
  • aromatic-amino-acid:2-oxoglutarate aminotransferase activity
    		•  0.0916183433120769 bayes_pls_golite062009
  • cystathionine beta-lyase activity
    		•  0.0833010353195099 bayes_pls_golite062009
  • amine binding
    		•  0.00719250700539997 bayes_pls_golite062009
  • kynureninase activity
    		•  0.0041576792340694 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle