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Protein Overview: Pms2-PA

General Information:
Name(s) found: Pms2-PA / FBpp0086520 [FlyBase]
Description(s) found:
Found 21 descriptions.
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  • The gene Pms2 is referred to in FlyBase by the symbol Dmel\Pms2 (CG8169, FBgn0011660). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 2R:11255577..11259021. It has the cytological map location 51F11. An electronic pipeline based on InterPro domains suggests that it has the molecular function</span>: mismatched DNA binding; ATP binding. Based on sequence similarity, it is predicted to be involved in the biological process</span>: mismatch repair. 4 alleles are reported. No phenotypic data is available. It has one annotated transcript and one annotated polypeptide. [FlyBase]
    • Organism: Drosophila melanogaster
    Length: 899 amino acids

    Gene Ontology:
    Cellular Component: NONE FOUND
    Biological Process: mismatch repair [ISS]
    Molecular Function: ATP binding [IEA]
    mismatched DNA binding [IEA]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MLETNYNADT EEEPDVPPPT TALSGQIKAI GKDTVHKICS GQVVLSLAVA VKELVENSID  60
   61 AGATLVEIKL KDQGLQSVEV SDNGSGVEEM NLEGMTAKYH TSKIREFVDL LGVETFGFRG 120
  121 EALSSLCALS DMVIQTRHKS TDVGVKVELD HEGRIKKRSP CARGVGTTVL LANLFSTLPV 180
  181 RRRDFTRNIK KEFTKMCQIL QAYCLVTKGV RILCSNHTPK GAKTIVLQTH GDQEVMANIS 240
  241 AIFGARQAAD LVPLKSPFGQ GQLTEAELRA DLESGADLAD TTSPQISTED VERLNQADFQ 300
  301 LEGFISSCRH GAGRSSRDRQ FFFVNSRPCD PKNIAKVMNE VYHRYNVQQQ PFIYLNIITA 360
  361 RSDVDVNLTP DKRQLLINNE RILLLALKKS LLDTFGQTPA TFQMQNTTIV SMLEPKTNSG 420
  421 KTKFPKESSK DDQHEEVSEE DVPTTSTQRF MDVLTQWRRT GDTKGTAPSV PVKRRCSESE 480
  481 ELVTRTLKMQ KIHTFLSQES PNEQSSKCEA ESDAASDVDM AKKDKTQVSL DNSFLNLKEL 540
  541 AKESEAYDLL TKPQNTPRID CKVLTPIKSR RSIFEFKTDA MALDKQESPA ELNSQPPSFT 600
  601 QLSEETDIAS DEDDHIELPT RIEFDEEMEE GLPSNFSSGE ITTSLEEIAS SLKAHEQQQR 660
  661 DRRTRTKLQR LRFKTEINPN QNTSAEAELQ REIDKEDFAR MEIIGQFNLG FIIVKLEDDL 720
  721 FIVDQHATDE KYNFETLQRT TQLEYQRLAV PQNLELTAVN EMVLLNHIDV FEKNGFKFEV 780
  781 DHEAPATKKV RLLGKPHSKR WEFGKEDIDE LIFMLQDAPE GTICRPSRVR AMFASRACRK 840
  841 SVMIGTALSR NTTMRRLITQ MGEIEQPWNC PHGRPTMRHL INIAMLINSD ENDEQEPPA

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    SHOWING SINGLE HITS. [ Hide Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..407] PSI-BLAST 73.154902 DNA mismatch repair protein PMS2
    2 View Details [408..649] PSI-BLAST 6.69897 No description for 2cgeA was found.
    3 View Details [650..899] PSI-BLAST 24.69897 Crystal structure of the MutL C-terminal domain

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • catalytic activity
    		•  2.4793446884777 bayes_pls_golite062009
  • protein kinase activity
    		•  1.48094914662788 bayes_pls_golite062009
  • signal transducer activity
    		•  1.37080468175244 bayes_pls_golite062009
  • molecular transducer activity
    		•  1.37080468175244 bayes_pls_golite062009
  • transferase activity, transferring phosphorus-containing groups
    		•  1.36033057569078 bayes_pls_golite062009
  • kinase activity
    		•  1.31787290977231 bayes_pls_golite062009
  • transferase activity
    		•  1.29436538270168 bayes_pls_golite062009
  • phosphotransferase activity, alcohol group as acceptor
    		•  1.22121888219398 bayes_pls_golite062009
  • mismatched DNA binding
    		•  1.18608754652723 bayes_pls_golite062009
  • DNA topoisomerase activity
    		•  0.50902250105843 bayes_pls_golite062009
  • DNA topoisomerase (ATP-hydrolyzing) activity
    		•  0.44633100500042 bayes_pls_golite062009
  • DNA insertion or deletion binding
    		•  0.0855237893557499 bayes_pls_golite062009
  • mismatch repair complex binding
    		•  0.0315838449561099 bayes_pls_golite062009
    2 No functions predicted.
    3 No functions predicted.


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.90

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle