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View Structure Prediction Details

Protein: Pms2-PA
Organism: Drosophila melanogaster
Length: 899 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for Pms2-PA.

Description E-value Query
Range
Subject
Range
gi|17863002 - gi|17863002|gb|AAL39978.1| SD07911p [Drosophila melanogaster]
531.0 [0..1] [899..1]

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Predicted Domain #1
Region A:
Residues: [1-407]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MLETNYNADT EEEPDVPPPT TALSGQIKAI GKDTVHKICS GQVVLSLAVA VKELVENSID  60
   61 AGATLVEIKL KDQGLQSVEV SDNGSGVEEM NLEGMTAKYH TSKIREFVDL LGVETFGFRG 120
  121 EALSSLCALS DMVIQTRHKS TDVGVKVELD HEGRIKKRSP CARGVGTTVL LANLFSTLPV 180
  181 RRRDFTRNIK KEFTKMCQIL QAYCLVTKGV RILCSNHTPK GAKTIVLQTH GDQEVMANIS 240
  241 AIFGARQAAD LVPLKSPFGQ GQLTEAELRA DLESGADLAD TTSPQISTED VERLNQADFQ 300
  301 LEGFISSCRH GAGRSSRDRQ FFFVNSRPCD PKNIAKVMNE VYHRYNVQQQ PFIYLNIITA 360
  361 RSDVDVNLTP DKRQLLINNE RILLLALKKS LLDTFGQTPA TFQMQNT

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 73.154902
Match: 1h7sA
Description: DNA mismatch repair protein PMS2
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
catalytic activity 2.4793446884777 bayes_pls_golite062009
protein kinase activity 1.48094914662788 bayes_pls_golite062009
signal transducer activity 1.37080468175244 bayes_pls_golite062009
molecular transducer activity 1.37080468175244 bayes_pls_golite062009
transferase activity, transferring phosphorus-containing groups 1.36033057569078 bayes_pls_golite062009
kinase activity 1.31787290977231 bayes_pls_golite062009
transferase activity 1.29436538270168 bayes_pls_golite062009
phosphotransferase activity, alcohol group as acceptor 1.22121888219398 bayes_pls_golite062009
mismatched DNA binding 1.18608754652723 bayes_pls_golite062009
DNA topoisomerase activity 0.50902250105843 bayes_pls_golite062009
DNA topoisomerase (ATP-hydrolyzing) activity 0.44633100500042 bayes_pls_golite062009
DNA insertion or deletion binding 0.0855237893557499 bayes_pls_golite062009
mismatch repair complex binding 0.0315838449561099 bayes_pls_golite062009

Predicted Domain #2
Region A:
Residues: [408-649]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 TIVSMLEPKT NSGKTKFPKE SSKDDQHEEV SEEDVPTTST QRFMDVLTQW RRTGDTKGTA  60
   61 PSVPVKRRCS ESEELVTRTL KMQKIHTFLS QESPNEQSSK CEAESDAASD VDMAKKDKTQ 120
  121 VSLDNSFLNL KELAKESEAY DLLTKPQNTP RIDCKVLTPI KSRRSIFEFK TDAMALDKQE 180
  181 SPAELNSQPP SFTQLSEETD IASDEDDHIE LPTRIEFDEE MEEGLPSNFS SGEITTSLEE 240
  241 IA

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 6.69897
Match: 2cgeA
Description: No description for 2cgeA was found.

Predicted Domain #3
Region A:
Residues: [650-899]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 SSLKAHEQQQ RDRRTRTKLQ RLRFKTEINP NQNTSAEAEL QREIDKEDFA RMEIIGQFNL  60
   61 GFIIVKLEDD LFIVDQHATD EKYNFETLQR TTQLEYQRLA VPQNLELTAV NEMVLLNHID 120
  121 VFEKNGFKFE VDHEAPATKK VRLLGKPHSK RWEFGKEDID ELIFMLQDAP EGTICRPSRV 180
  181 RAMFASRACR KSVMIGTALS RNTTMRRLIT QMGEIEQPWN CPHGRPTMRH LINIAMLINS 240
  241 DENDEQEPPA 

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 24.69897
Match: 1x9zA
Description: Crystal structure of the MutL C-terminal domain
Matching Structure (courtesy of the PDB):

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle