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Protein Overview: shot-PC

General Information:
Name(s) found: shot-PC / FBpp0086746 [FlyBase]
Description(s) found:
Found 20 descriptions.
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  • The gene short stop is referred to in FlyBase by the symbol Dmel\shot (CG18076, FBgn0013733). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 2R:9751742..9829615. It has the cytological map location 50C6-50C9. There is experimental evidence that it has the molecular function</span>: protein binding. There is experimental evidence that it is involved in the biological process</span>: negative regulation of microtubule depolymerization; dendrite morphogenesis; oocyte fate determination; regulation of axon extension; microtubule cytoskeleton organization; mushroom body development; open tracheal system development; branch fusion, open tracheal system; lumen formation, open tracheal system; axon midline choice point recognition. 76 alleles are reported. The phenotypes of these alleles are annotated with 25 unique terms, many of which group under: organ system; multi-cell-component structure; peripheral nervous system; nervous system; anatomical structure; ectoderm derivative; embryonic/larval tracheal system; embryonic nervous system; portion of tissue; embryonic neuron. It has 15 annotated transcripts and 15 annotated polypeptides. [FlyBase]
    • Organism: Drosophila melanogaster
    Length: 5160 amino acids

    Gene Ontology:
    Cellular Component: growth cone [IDA]
    adherens junction [IDA][TAS]
    cytoskeleton [NAS]
    fusome [IDA]
    astral microtubule [IDA]
    microtubule [IDA][TAS]
    Biological Process: cell cycle arrest [IEA]
    mushroom body development [IMP]
    negative regulation of microtubule depolymerization [IMP]
    apposition of dorsal and ventral imaginal disc-derived wing surfaces [TAS]
    microtubule cytoskeleton organization [IMP][TAS]
    sensory organ development [TAS]
    microtubule-based process [ISS][NAS]
    dendrite morphogenesis [IMP][TAS]
    open tracheal system development [IMP][TAS]
    muscle organ development [NAS]
    regulation of axon extension [IMP]
    oocyte fate determination [IMP]
    axonogenesis [TAS]
    axon midline choice point recognition [IMP]
    branch fusion, open tracheal system [IEP][IMP][TAS]
    actin cytoskeleton organization [TAS]
    muscle attachment [NAS][TAS]
    lumen formation, open tracheal system [IMP]
    determination of muscle attachment site [TAS]
    Molecular Function: protein binding [IPI]
    actin binding [ISS][TAS]
    calcium ion binding [IEA]
    cytoskeletal protein binding [ISS]
    microtubule binding [ISS][TAS]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MHSSSQSTLK RTQQLVRQTN GGRGDVLSSG SEVVHSSRGP AITTNIDDSN LRYRHETKRE  60
   61 RTVEAVITDY PGVSPLGSVP HERTNFERTV TFQDPTGNSR RLSETGALVP AGAIPTSSTH 120
  121 YQQVTRNKRI STEVLGSSVE STKTSQRAPN GHRRVTTHIV RKVTTLSRAE ENAQPAEDLL 180
  181 PPAKMIRSSE LEYRRALPPA IESSSTQRRE ISDIVVGKED NVSAREALLR WARRSTARYP 240
  241 GVRVNDFTSS WRDGLAFSAL VHRNRPDLLD WRKARNDRPR ERLETAFHIV EKEYGVTRLL 300
  301 DPEDVDTNEP DEKSLITYIS SLYDVFPEPP SIHPLFDMES QRRVHEYRDL AQQFIYWCRE 360
  361 KTAYLQERSF PPTLIEMKRL LSDLQRFRSD EVSARKREKS KLIQIYKELE RYFETVGEVD 420
  421 VEAELRPDAI EKAWYRMNTA LQDREVILQQ EIERLERLQR LADKVQREIK HVDQKLTDLE 480
  481 GRIGEEGRRI ERLHPVDAKS IVEALETEIR HLEEPIQDMN QDCHVLNEGR YPHVSELHKK 540
  541 VNKLHQRWAQ LRTNFHTNLV QKLSGLKYPV HETTVTRQTR MVVESRQIDT NPHFRDLQEH 600
  601 IEWCQNKLKQ LLAADYGSDL PSVKEELDRQ QHEHKIIDQF HTKILNDERQ QTKFSGDELA 660
  661 LYQQRLNQLQ KVYAELLSTS TKRLSDLDSL QHFLGQASAE LQWLNEKEQV EITRDWADKQ 720
  721 LDLPSVHRYY ENLMSELEKR EMHFATILDR GEALLNQQHP ASKCIEAHLT ALQQQWAWLL 780
  781 QLTLCLEVHL KHATEYHQFF GEIKDAEQWL AKRDEILNSK FSQSDFGLDQ GETLLRGMQD 840
  841 LREELNAFGE TVATLQRRAQ TVVPLNKRRQ PVNRQGPVQA ICAYKQQGQL QIEKGETVTL 900
  901 LDNSGRVKWR VRTAKGQEGP IPGACLLLPP PDQEAIDAAE RLKRLFDRSV ALWQKKHLRL 960
  961 RQNMIFATIR VVKGWDFDQF LAMGPEQRTA IRRALNDDAD KLLSEGDPND PQLRRLRREM1020
 1021 DEVNRLFDEF EKRARAEEES KQASRIFTEE CLAIKSKLED MARELDQIIL APLPRDLDSL1080
 1081 EHVLEIHSDY ERRLHLLEPE LKHLQETFRT IALKTPVLKK SLDNLMELWK ELNTQSGLHK1140
 1141 DRLKLLEASL AGLEDNEHVI SELENELARH QDLPSTAEGL QQVFKQLNHM QDIITQQQPQ1200
 1201 MDKMNDAADQ LGRMGVPTKV LGDLKRLHSN VERLNTRWSA VCNQLGERMR SCETAIGLMK1260
 1261 NLQSSVQVEE SWVDGTTERL SAMPTATSAY ELDQAVFEKF NMCEENVNDL LKWVTTVEQK1320
 1321 ISSVGGPREK IDELRNQINA LKQIKDEIES QQRPVATCLE QIRQIVLTGG DVLSAPEVTT1380
 1381 LENSGRELRS RVDRVNDRTV RLLRRLEAGR DELTKLRSEL DVFSDWLQVA RRTLEDKERS1440
 1441 LSDLTRLPSQ ADSVREFVSD VIGHQADLRF ITMAAQKFVD ESKEFLAILN DFRTSLPERL1500
 1501 PHVEPLSSAE SPIRQEVSLV SAQYKDLLNR VNALQDRVSG LGGRQREYQD ALDKANEWLR1560
 1561 SVHPRVSRII SEPIAGDPKG VQDQMNEAKA LHNELLSSGR LVDNAQQALD NLLRSLGGQL1620
 1621 SPMEINQLEL PIADLKNNYQ QLLDNLGEHC KTLDKTLVQS QGVQDALDSL VGWVNQAEDK1680
 1681 FKMNLRPASL IKERLQEQIR EHKVLLADLQ SHQASIDSVQ VSAKHLLASA SNARIAKKVE1740
 1741 SNLNDVTVKF EKLYEKANKR GEFLDDVYNR LSRYLDEIST VEQRMASLQE ALDSRETSLL1800
 1801 STEELARRMN ELSRDKDQLA PQFEDCVRSG KDLISLRDVT DTGVLRDRIK ALESQWRNIN1860
 1861 ISIDERAKLS KQKAEQQLAY EGLKDQVLSW LASTEARVNG LPPVAIDLDR IKQQHDELKP1920
 1921 ICKDYRDYAP TIDKINDIGA QYDALIRPES PARKRSTYSP IKRTSPLRRM SGDARSPSPT1980
 1981 KGGILSPLST GSSGFGSRRS SQDGFQLSEL SPVQQQLSEI NNRYGLIGVR LNDRQHELDN2040
 2041 LNEELRKQYE NLKGLAQFLE RIQRQLPKES VSNKDEAERC IKQARKILED MYEKQSLLDT2100
 2101 TKAQVKDILR RKSDVPGAEQ LRQENDSIQE KWKNLNDICK NRIAFSEKLR DFLDTHGNLK2160
 2161 SWLDSKERML TVLGPISSDP RMVQSQVQQV QVLREEFRTQ QPQLKHFQEL GHDVVDHLAG2220
 2221 TPDAQAVEIK LKDILGKWDD LVGKLDDRAN SLGGAADSSK EFDAAVNRLR EALQNISDNL2280
 2281 DTLPTDGDHQ ENLRKIENLE RQLEGQRPLL ADVEQSAATL CNILGDPASR ADVNSRVAAL2340
 2341 EKQYLALQKK LDTKKAETEA SLRDGRHFAE NCSKTLGWLG GELSNLTDRL LVSAHKPTLQ2400
 2401 HQIDTHEPIY REVMAREHEV IMLINKGKDL TDRQQDRGVK RDLDRIQQQW EKLRREAVDR2460
 2461 HTRLQTCMEH CKKYSQTSET FLAWLRTAED KLADLTPGVL SKAKLETRLR DLQTFRSEVW2520
 2521 KHSGEFENTK GLGETFLSSC DIDKEPIKAE LQDIRDRWER LNNDLIARAH EIENCSRRLD2580
 2581 DFNDELRNLD HSLGRCEDRL AAHDALGGAA KDPKLLERVK AIREELTNLS KPLQSLKALA2640
 2641 KDISAEARAA GGDADHLTSE VDGLADRMSE LQGRLDDRCG ELQSAATAVS QFNEQMKSLG2700
 2701 IDLNDLETEI EKLSPPGREI KIVQVQIDDV GKIQTKLDRL VGRLEDAERA ADVLVDAGFA2760
 2761 ADTTQTREQI STLRKTLGRL DNRVRDHEDN LHSTLKALRE FYDHQSQTLD DIQDVSDEFK2820
 2821 RMKPVGSELD QIRRQQEDFR NFRERKVEPL AINVDKVNVA GRDLVRSAGS GVSTTAIEKD2880
 2881 LEKLNDRWND LKERMNERDR RLDVALLQSG KFQEALAGLS KWLSDTEEMV ANQKPPSSDY2940
 2941 KVVKAQLQEQ KFLKKMLLDR QNSMGSLANL GKEVANHCEP GERASIEKQL NDLMKRFDAL3000
 3001 TDGAEQRELD LEEAMEVAKR FHDKISPLEL WLDNTERSVK AMELIPTDEE KIQQRIREHD3060
 3061 RLHDEILGKK PDFSDLADVT AQLMHLVSDE EAVNLGEKVR GVTERYTGLV DASDNIGALL3120
 3121 AESRQGLRHL VLSYQDLVAW MESMEAELKR FKSVPVYAEK LLEQMDHLLE LNENIAGHAS3180
 3181 NVESTVESGA ELMKHISNDE AIQLKDKLDS LQRRYGDLTN RGGDLLKSAQ NALPLVQQFH3240
 3241 EAHNRLVEWM QSAEAALAPS EPRQADVLRL EGELADMRPI LDSINQVGPQ LCQLSPGEGA3300
 3301 ATIESIVTRD NRRFDSIVEQ IQRKAERLHL SNQRAKEVTG DIDELLEWFR EMDTTLREAD3360
 3361 LPAMEPKLVR AQLQEHRSIN DDISSQKGRV RDVTAASKKV LRESPQSENT ATLREKLDDL3420
 3421 KEIVDTVAQL CSERLGILEQ ALPLSEHFAD SHQGLTAWLD DMEQQISRLS MPALRPDQIT3480
 3481 LQQDKNERLL QSIAEHKPLL DKLNKTGEAL GALVADDDGA KINEILDTDN ARYAALRLEL3540
 3541 RERQQALESA LQESSQFSDK LEGMLRALAN TVDQVNQLDP LSALPQKIRE QIEDNDALMD3600
 3601 DLDKRQDAFS AVQRAANDVI AKAGNKADPA VRDIKAKLEK LNNLWNDVQN ATKKRGSSLD3660
 3661 DILSVAEPFW KQLNSVMKTL KDLEETLSCQ EPPAAQPQDI KKQQVALQEI RHEIDQTKPE3720
 3721 VEQVRRHGSN LMNMCGEPDK PEVKKHIEDL DNAWDNITAL YAKREENLID AMEKAMEFHE3780
 3781 TLQNLLKFLT KAEDKFAHLG AVGSDIDAVK RQIEQLKSFK DEVDPHMVEV EALNRQAVEL3840
 3841 TERTSPEQAA SIREPLSVVN RRWEALLRGM VERQKQLEHA LLHLGQFQHA LNELLVWINK3900
 3901 TDSTLDQLKP IPGDPQLLEV ELAKLKVLAN DIQAHQNSVD TLNDAGRQLI ETEKGSVEAS3960
 3961 TTQEKLRKLN NEWKQLLQKA SDRQHELEEA LREAHGYIAE VQDILGWLGD VDAVIGASKP4020
 4021 VGGLPETATE QLERFMEVYN ELDENRPKVE TIQAQGQEYI KRQNQMKVSS SNLQHTLRTL4080
 4081 KQRWDAVVSR ASDKKIKLEI ALKEATEFHD TLQAFVEWLT QAEKLLSNAE PVSRVLETIQ4140
 4141 AQMEEHKVLQ KDVSTHREAM LLLDKKGTHL KYFSQKQDVI LIKNLLVSVQ HRWERVVSKA4200
 4201 AERTRALDHG YKEAREFNDA WSGMMQYLQE TEQVLDQIIE EATASKEPQK IKKYIGKLKE4260
 4261 THRQLGAKQS VYDGTMRTGK NLLERAPKGD RPVLDKMLIE LKEQWTRVWS KSIDRQRKLE4320
 4321 EALLLSGQFS DALGELLDWL KKAKSRLNEN GPVHGDLETV QGLCEHHKHI EQDLQKRAAQ4380
 4381 MQGVLKTGRD LERSGNNPEV GRQLDEMQSI WEEVKSAVAK RGERLQVALV DAEKLNARVQ4440
 4441 ALFDWLDHAE HKLRYAKNAP DDEKVSREMM DIHMDFMKDL RVREREKTET FEYAEDIINK4500
 4501 AYPDAIPIIK NWLSIIQQRW EEVRQWAINR ESKLEQHLQS LKDLDDTIEE LLAWLSGLEG4560
 4561 TLLNLKHEQL PDEIPPVEKL IEDHKEFMEN TARRQNEVDR ACKPRQLPPG ARKPSRSGKT4620
 4621 PVFKGSRDQG LNARKGSRIT PTRDTPDRDR LPHYGPRFSP STSGPELEFR SPRAKLLWTK4680
 4681 WRDVWMLSWE RQRLLNDHLL YLKDVERARN FSWDDWRKRF LKYMNHKKSR LTDLFRKMDK4740
 4741 DNNGMIPRDV FIDGILNTKF DTSGLEMKAV ADLFDRNGEG LIDWQEFIAA LRPDWQERKP4800
 4801 ANDSDKIHDE VKRLVMLCTC RQKFRVFQVG EGKYRFGDSQ KLRLVRILRS TVMVRVGGGW4860
 4861 VALDEFLQKN DPCRAKGRTN IELREQFILA DGVSQSMAAF TPRRSTPNAA ATASSSPHAH4920
 4921 NGGSSNLPPY MSGQGPIIKV RERSVRSIPM SRPSRSSLSA STPDSLSDNE GSHGGPSGRY4980
 4981 TPRKVTYTST RTGLTPGGSR AGSKPNSRPL SRQGSKPPSR HGSTLSLDST DDHTPSRIPQ5040
 5041 RKPSTGSTAS GTTPRPARLS VTTTTTPGSR LNGTSTITRK TASGSASPAP TSNGGMSRSS5100
 5101 SIPALTGFGF KPIRRNISGS STPSGMQTPR KSSAEPTFSS TMRRTSRGTT PTEKREPFRL5160
 5161

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

    No microscopy data found in the PDR for this protein.

    Protein Structure Data



    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle