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Protein Overview: shot-PA

General Information:
Name(s) found: shot-PA / FBpp0086745 [FlyBase]
Description(s) found:
Found 19 descriptions.
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  • The gene short stop is referred to in FlyBase by the symbol Dmel\shot (CG18076, FBgn0013733). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 2R:9751742..9829615. It has the cytological map location 50C6-50C9. There is experimental evidence that it has the molecular function</span>: protein binding. There is experimental evidence that it is involved in the biological process</span>: negative regulation of microtubule depolymerization; dendrite morphogenesis; oocyte fate determination; regulation of axon extension; microtubule cytoskeleton organization; mushroom body development; open tracheal system development; branch fusion, open tracheal system; lumen formation, open tracheal system; axon midline choice point recognition. 76 alleles are reported. The phenotypes of these alleles are annotated with 25 unique terms, many of which group under: organ system; multi-cell-component structure; peripheral nervous system; nervous system; anatomical structure; ectoderm derivative; embryonic/larval tracheal system; embryonic nervous system; portion of tissue; embryonic neuron. It has 15 annotated transcripts and 15 annotated polypeptides. [FlyBase]
    • Organism: Drosophila melanogaster
    Length: 5501 amino acids

    Gene Ontology:
    Cellular Component: growth cone [IDA]
    adherens junction [IDA][TAS]
    cytoskeleton [NAS]
    fusome [IDA]
    astral microtubule [IDA]
    microtubule [IDA][TAS]
    Biological Process: cell cycle arrest [IEA]
    mushroom body development [IMP]
    negative regulation of microtubule depolymerization [IMP]
    apposition of dorsal and ventral imaginal disc-derived wing surfaces [TAS]
    microtubule cytoskeleton organization [IMP][TAS]
    sensory organ development [TAS]
    microtubule-based process [ISS][NAS]
    dendrite morphogenesis [IMP][TAS]
    open tracheal system development [IMP][TAS]
    muscle organ development [NAS]
    regulation of axon extension [IMP]
    oocyte fate determination [IMP]
    axonogenesis [TAS]
    axon midline choice point recognition [IMP]
    branch fusion, open tracheal system [IEP][IMP][TAS]
    actin cytoskeleton organization [TAS]
    muscle attachment [NAS][TAS]
    lumen formation, open tracheal system [IMP]
    determination of muscle attachment site [TAS]
    Molecular Function: protein binding [IPI]
    actin binding [ISS][TAS]
    calcium ion binding [IEA]
    cytoskeletal protein binding [ISS]
    microtubule binding [ISS][TAS]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MTSHSYYKDR LGFDPNEQQP GSNNSMKRSS SRQTTHHHQS YHHATTSSSQ SPARISVSPG  60
   61 GNNGTLEYQQ VQREQRDREL YSNNGSLHHH QHHHHHHRHS TTGSASSPLY ENSSSPAAPK 120
  121 KAKHSSTQAQ PQGGYEDALT QFKDERDAIQ KKTFTKWVNK HLKKANRRVV DLFEDLRDGH 180
  181 NLLSLLEVLS GEHLPREKGK MRFHMLQNAQ MALDFLRYKK IKLVNIRAED IVDGNPKLTL 240
  241 GLIWTIILHF QISDIVVGKE DNVSAREALL RWARRSTARY PGVRVNDFTS SWRDGLAFSA 300
  301 LVHRNRPDLL DWRKARNDRP RERLETAFHI VEKEYGVTRL LDPEDVDTNE PDEKSLITYI 360
  361 SSLYDVFPEP PSIHPLFDME SQRRVHEYRD LAQQFIYWCR EKTAYLQERS FPPTLIEMKR 420
  421 LLSDLQRFRS DEVSARKREK SKLIQIYKEL ERYFETVGEV DVEAELRPDA IEKAWYRMNT 480
  481 ALQDREVILQ QEIERLERLQ RLADKVQREI KHVDQKLTDL EGRIGEEGRR IERLHPVDAK 540
  541 SIVEALETEI RHLEEPIQDM NQDCHVLNEG RYPHVSELHK KVNKLHQRWA QLRTNFHTNL 600
  601 VQKLSGLKYP VHETTVTRQT RMVVESRQID TNPHFRDLQE HIEWCQNKLK QLLAADYGSD 660
  661 LPSVKEELDR QQHEHKIIDQ FHTKILNDER QQTKFSGDEL ALYQQRLNQL QKVYAELLST 720
  721 STKRLSDLDS LQHFLGQASA ELQWLNEKEQ VEITRDWADK QLDLPSVHRY YENLMSELEK 780
  781 REMHFATILD RGEALLNQQH PASKCIEAHL TALQQQWAWL LQLTLCLEVH LKHATEYHQF 840
  841 FGEIKDAEQW LAKRDEILNS KFSQSDFGLD QGETLLRGMQ DLREELNAFG ETVATLQRRA 900
  901 QTVVPLNKRR QPVNRQGPVQ AICAYKQQGQ LQIEKGETVT LLDNSGRVKW RVRTAKGQEG 960
  961 PIPGACLLLP PPDQEAIDAA ERLKRLFDRS VALWQKKHLR LRQNMIFATI RVVKGWDFDQ1020
 1021 FLAMGPEQRT AIRRALNDDA DKLLSEGDPN DPQLRRLRRE MDEVNRLFDE FEKRARAEEE1080
 1081 SKQASRIFTE ECLAIKSKLE DMARELDQII LAPLPRDLDS LEHVLEIHSD YERRLHLLEP1140
 1141 ELKHLQETFR TIALKTPVLK KSLDNLMELW KELNTQSGLH KDRLKLLEAS LAGLEDNEHV1200
 1201 ISELENELAR HQDLPSTAEG LQQVFKQLNH MQDIITQQQP QMDKMNDAAD QLGRMGVPTK1260
 1261 VLGDLKRLHS NVERLNTRWS AVCNQLGERM RSCETAIGLM KNLQSSVQVE ESWVDGTTER1320
 1321 LSAMPTATSA YELDKLLGAA IERKPKIENV NVAGGRLIRE AKIYDSKCLR FVDWLVEARP1380
 1381 SFSPPRRDLR PADSDPGATQ YYSQRLDNLN TKNDRLLEQL SQRLKTAIEV NGSDGLQYAE1440
 1441 SLQKPLKTFR VDFSAGSVPT GDGYAARQED LYTTTYSTTQ ISSTKTTKSS TKSVYSSDGL1500
 1501 DAASQEVSTA GLPQSQIQFN EIRTLKRSQQ LGGHSVLDIA GIRDPRTGRV LTIGEAIQLR1560
 1561 ILDVRTGEML VGDRRITLEQ AADQGLIDLQ LAKQLLEPGA GRDASGRELS LLEVIQREIS1620
 1621 EAESGYETAE KRIKQAVFEK FNMCEENVND LLKWVTTVEQ KISSVGGPRE KIDELRNQIN1680
 1681 ALKQIKDEIE SQQRPVATCL EQIRQIVLTG GDVLSAPEVT TLENSGRELR SRVDRVNDRT1740
 1741 VRLLRRLEAG RDELTKLRSE LDVFSDWLQV ARRTLEDKER SLSDLTRLPS QADSVREFVS1800
 1801 DVIGHQADLR FITMAAQKFV DESKEFLAIL NDFRTSLPER LPHVEPLSSA ESPIRQEVSL1860
 1861 VSAQYKDLLN RVNALQDRVS GLGGRQREYQ DALDKANEWL RSVHPRVSRI ISEPIAGDPK1920
 1921 GVQDQMNEAK ALHNELLSSG RLVDNAQQAL DNLLRSLGGQ LSPMEINQLE LPIADLKNNY1980
 1981 QQLLDNLGEH CKTLDKTLVQ SQGVQDALDS LVGWVNQAED KFKMNLRPAS LIKERLQEQI2040
 2041 REHKVLLADL QSHQASIDSV QVSAKHLLAS ASNARIAKKV ESNLNDVTVK FEKLYEKANK2100
 2101 RGEFLDDVYN RLSRYLDEIS TVEQRMASLQ EALDSRETSL LSTEELARRM NELSRDKDQL2160
 2161 APQFEDCVRS GKDLISLRDV TDTGVLRDRI KALESQWRNI NISIDERAKL SKQKAEQQLA2220
 2221 YEGLKDQVLS WLASTEARVN GLPPVAIDLD RIKQQHDELK PICKDYRDYA PTIDKINDIG2280
 2281 AQYDALIRPE SPARKRSTYS PIKRTSPLRR MSGDARSPSP TKGGILSPLS TGSSGFGSRR2340
 2341 SSQDGFQLSE LSPVQQQLSE INNRYGLIGV RLNDRQHELD NLNEELRKQY ENLKGLAQFL2400
 2401 ERIQRQLPKE SVSNKDEAER CIKQARKILE DMYEKQSLLD TTKAQVKDIL RRKSDVPGAE2460
 2461 QLRQENDSIQ EKWKNLNDIC KNRIAFSEKL RDFLDTHGNL KSWLDSKERM LTVLGPISSD2520
 2521 PRMVQSQVQQ VQVLREEFRT QQPQLKHFQE LGHDVVDHLA GTPDAQAVEI KLKDILGKWD2580
 2581 DLVGKLDDRA NSLGGAADSS KEFDAAVNRL REALQNISDN LDTLPTDGDH QENLRKIENL2640
 2641 ERQLEGQRPL LADVEQSAAT LCNILGDPAS RADVNSRVAA LEKQYLALQK KLDTKKAETE2700
 2701 ASLRDGRHFA ENCSKTLGWL GGELSNLTDR LLVSAHKPTL QHQIDTHEPI YREVMAREHE2760
 2761 VIMLINKGKD LTDRQQDRGV KRDLDRIQQQ WEKLRREAVD RHTRLQTCME HCKKYSQTSE2820
 2821 TFLAWLRTAE DKLADLTPGV LSKAKLETRL RDLQTFRSEV WKHSGEFENT KGLGETFLSS2880
 2881 CDIDKEPIKA ELQDIRDRWE RLNNDLIARA HEIENCSRRL DDFNDELRNL DHSLGRCEDR2940
 2941 LAAHDALGGA AKDPKLLERV KAIREELTNL SKPLQSLKAL AKDISAEARA AGGDADHLTS3000
 3001 EVDGLADRMS ELQGRLDDRC GELQSAATAV SQFNEQMKSL GIDLNDLETE IEKLSPPGRE3060
 3061 IKIVQVQIDD VGKIQTKLDR LVGRLEDAER AADVLVDAGF AADTTQTREQ ISTLRKTLGR3120
 3121 LDNRVRDHED NLHSTLKALR EFYDHQSQTL DDIQDVSDEF KRMKPVGSEL DQIRRQQEDF3180
 3181 RNFRERKVEP LAINVDKVNV AGRDLVRSAG SGVSTTAIEK DLEKLNDRWN DLKERMNERD3240
 3241 RRLDVALLQS GKFQEALAGL SKWLSDTEEM VANQKPPSSD YKVVKAQLQE QKFLKKMLLD3300
 3301 RQNSMGSLAN LGKEVANHCE PGERASIEKQ LNDLMKRFDA LTDGAEQREL DLEEAMEVAK3360
 3361 RFHDKISPLE LWLDNTERSV KAMELIPTDE EKIQQRIREH DRLHDEILGK KPDFSDLADV3420
 3421 TAQLMHLVSD EEAVNLGEKV RGVTERYTGL VDASDNIGAL LAESRQGLRH LVLSYQDLVA3480
 3481 WMESMEAELK RFKSVPVYAE KLLEQMDHLL ELNENIAGHA SNVESTVESG AELMKHISND3540
 3541 EAIQLKDKLD SLQRRYGDLT NRGGDLLKSA QNALPLVQQF HEAHNRLVEW MQSAEAALAP3600
 3601 SEPRQADVLR LEGELADMRP ILDSINQVGP QLCQLSPGEG AATIESIVTR DNRRFDSIVE3660
 3661 QIQRKAERLH LSNQRAKEVT GDIDELLEWF REMDTTLREA DLPAMEPKLV RAQLQEHRSI3720
 3721 NDDISSQKGR VRDVTAASKK VLRESPQSEN TATLREKLDD LKEIVDTVAQ LCSERLGILE3780
 3781 QALPLSEHFA DSHQGLTAWL DDMEQQISRL SMPALRPDQI TLQQDKNERL LQSIAEHKPL3840
 3841 LDKLNKTGEA LGALVADDDG AKINEILDTD NARYAALRLE LRERQQALES ALQESSQFSD3900
 3901 KLEGMLRALA NTVDQVNQLD PLSALPQKIR EQIEDNDALM DDLDKRQDAF SAVQRAANDV3960
 3961 IAKAGNKADP AVRDIKAKLE KLNNLWNDVQ NATKKRGSSL DDILSVAEPF WKQLNSVMKT4020
 4021 LKDLEETLSC QEPPAAQPQD IKKQQVALQE IRHEIDQTKP EVEQVRRHGS NLMNMCGEPD4080
 4081 KPEVKKHIED LDNAWDNITA LYAKREENLI DAMEKAMEFH ETLQNLLKFL TKAEDKFAHL4140
 4141 GAVGSDIDAV KRQIEQLKSF KDEVDPHMVE VEALNRQAVE LTERTSPEQA ASIREPLSVV4200
 4201 NRRWEALLRG MVERQKQLEH ALLHLGQFQH ALNELLVWIN KTDSTLDQLK PIPGDPQLLE4260
 4261 VELAKLKVLA NDIQAHQNSV DTLNDAGRQL IETEKGSVEA STTQEKLRKL NNEWKQLLQK4320
 4321 ASDRQHELEE ALREAHGYIA EVQDILGWLG DVDAVIGASK PVGGLPETAT EQLERFMEVY4380
 4381 NELDENRPKV ETIQAQGQEY IKRQNQMKVS SSNLQHTLRT LKQRWDAVVS RASDKKIKLE4440
 4441 IALKEATEFH DTLQAFVEWL TQAEKLLSNA EPVSRVLETI QAQMEEHKVL QKDVSTHREA4500
 4501 MLLLDKKGTH LKYFSQKQDV ILIKNLLVSV QHRWERVVSK AAERTRALDH GYKEAREFND4560
 4561 AWSGMMQYLQ ETEQVLDQII EEATASKEPQ KIKKYIGKLK ETHRQLGAKQ SVYDGTMRTG4620
 4621 KNLLERAPKG DRPVLDKMLI ELKEQWTRVW SKSIDRQRKL EEALLLSGQF SDALGELLDW4680
 4681 LKKAKSRLNE NGPVHGDLET VQGLCEHHKH IEQDLQKRAA QMQGVLKTGR DLERSGNNPE4740
 4741 VGRQLDEMQS IWEEVKSAVA KRGERLQVAL VDAEKLNARV QALFDWLDHA EHKLRYAKNA4800
 4801 PDDEKVSREM MDIHMDFMKD LRVREREKTE TFEYAEDIIN KAYPDAIPII KNWLSIIQQR4860
 4861 WEEVRQWAIN RESKLEQHLQ SLKDLDDTIE ELLAWLSGLE GTLLNLKHEQ LPDEIPPVEK4920
 4921 LIEDHKEFME NTARRQNEVD RACKPRQLPP GARKPSRSGK TPVFKGSRDQ GLNARKGSRI4980
 4981 TPTRDTPDRD RLPHYGPRFS PSTSGPELEF RSPRAKLLWT KWRDVWMLSW ERQRLLNDHL5040
 5041 LYLKDVERAR NFSWDDWRKR FLKYMNHKKS RLTDLFRKMD KDNNGMIPRD VFIDGILNTK5100
 5101 FDTSGLEMKA VADLFDRNGE GLIDWQEFIA ALRPDWQERK PANDSDKIHD EVKRLVMLCT5160
 5161 CRQKFRVFQV GEGKYRFGDS QKLRLVRILR STVMVRVGGG WVALDEFLQK NDPCRAKGRT5220
 5221 NIELREQFIL ADGVSQSMAA FTPRRSTPNA AATASSSPHA HNGGSSNLPP YMSGQGPIIK5280
 5281 VRERSVRSIP MSRPSRSSLS ASTPDSLSDN EGSHGGPSGR YTPRKVTYTS TRTGLTPGGS5340
 5341 RAGSKPNSRP LSRQGSKPPS RHGSTLSLDS TDDHTPSRIP QRKPSTGSTA SGTTPRPARL5400
 5401 SVTTTTTPGS RLNGTSTITR KTASGSASPA PTSNGGMSRS SSIPALTGFG FKPIRRNISG5460
 5461 SSTPSGMQTP RKSSAEPTFS STMRRTSRGT TPTEKREPFR L

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

    No microscopy data found in the PDR for this protein.

    Protein Structure Data



    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle