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Protein Overview: shot-PE

General Information:
Name(s) found: shot-PE / FBpp0086744 [FlyBase]
Description(s) found:
Found 19 descriptions.
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  • The gene short stop is referred to in FlyBase by the symbol Dmel\shot (CG18076, FBgn0013733). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 2R:9751742..9829615. It has the cytological map location 50C6-50C9. There is experimental evidence that it has the molecular function</span>: protein binding. There is experimental evidence that it is involved in the biological process</span>: negative regulation of microtubule depolymerization; dendrite morphogenesis; oocyte fate determination; regulation of axon extension; microtubule cytoskeleton organization; mushroom body development; open tracheal system development; branch fusion, open tracheal system; lumen formation, open tracheal system; axon midline choice point recognition. 76 alleles are reported. The phenotypes of these alleles are annotated with 25 unique terms, many of which group under: organ system; multi-cell-component structure; peripheral nervous system; nervous system; anatomical structure; ectoderm derivative; embryonic/larval tracheal system; embryonic nervous system; portion of tissue; embryonic neuron. It has 15 annotated transcripts and 15 annotated polypeptides. [FlyBase]
    • Organism: Drosophila melanogaster
    Length: 5201 amino acids

    Gene Ontology:
    Cellular Component: growth cone [IDA]
    adherens junction [IDA][TAS]
    cytoskeleton [NAS]
    fusome [IDA]
    astral microtubule [IDA]
    microtubule [IDA][TAS]
    Biological Process: cell cycle arrest [IEA]
    mushroom body development [IMP]
    negative regulation of microtubule depolymerization [IMP]
    apposition of dorsal and ventral imaginal disc-derived wing surfaces [TAS]
    microtubule cytoskeleton organization [IMP][TAS]
    sensory organ development [TAS]
    microtubule-based process [ISS][NAS]
    dendrite morphogenesis [IMP][TAS]
    open tracheal system development [IMP][TAS]
    muscle organ development [NAS]
    regulation of axon extension [IMP]
    oocyte fate determination [IMP]
    axonogenesis [TAS]
    axon midline choice point recognition [IMP]
    branch fusion, open tracheal system [IEP][IMP][TAS]
    actin cytoskeleton organization [TAS]
    muscle attachment [NAS][TAS]
    lumen formation, open tracheal system [IMP]
    determination of muscle attachment site [TAS]
    Molecular Function: protein binding [IPI]
    actin binding [ISS][TAS]
    calcium ion binding [IEA]
    cytoskeletal protein binding [ISS]
    microtubule binding [ISS][TAS]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MTSHSYYKDR LGFDPNEQQP GSNNSMKRSS SRQTTHHHQS YHHATTSSSQ SPARISVSPG  60
   61 GNNGTLEYQQ VQREQRDREL YSNNGSLHHH QHHHHHHRHS TTGSASSPLY ENSSSPAAPK 120
  121 KAKHSSTQAQ PQGGYEDALT QFKDERDAIQ KKTFTKWVNK HLKKANRRVV DLFEDLRDGH 180
  181 NLLSLLEVLS GEHLPREKGK MRFHMLQNAQ MALDFLRYKK IKLVNIRAED IVDGNPKLTL 240
  241 GLIWTIILHF QISDIVVGKE DNVSAREALL RWARRSTARY PGVRVNDFTS SWRDGLAFSA 300
  301 LVHRNRPDLL DWRKARNDRP RERLETAFHI VEKEYGVTRL LDPEDVDTNE PDEKSLITYI 360
  361 SSLYDVFPEP PSIHPLFDME SQRRVHEYRD LAQQFIYWCR EKTAYLQERS FPPTLIEMKR 420
  421 LLSDLQRFRS DEVSARKREK SKLIQIYKEL ERYFETVGEV DVEAELRPDA IEKAWYRMNT 480
  481 ALQDREVILQ QEIERLERLQ RLADKVQREI KHVDQKLTDL EGRIGEEGRR IERLHPVDAK 540
  541 SIVEALETEI RHLEEPIQDM NQDCHVLNEG RYPHVSELHK KVNKLHQRWA QLRTNFHTNL 600
  601 VQKLSGLKYP VHETTVTRQT RMVVESRQID TNPHFRDLQE HIEWCQNKLK QLLAADYGSD 660
  661 LPSVKEELDR QQHEHKIIDQ FHTKILNDER QQTKFSGDEL ALYQQRLNQL QKVYAELLST 720
  721 STKRLSDLDS LQHFLGQASA ELQWLNEKEQ VEITRDWADK QLDLPSVHRY YENLMSELEK 780
  781 REMHFATILD RGEALLNQQH PASKCIEAHL TALQQQWAWL LQLTLCLEVH LKHATEYHQF 840
  841 FGEIKDAEQW LAKRDEILNS KFSQSDFGLD QGETLLRGMQ DLREELNAFG ETVATLQRRA 900
  901 QTVVPLNKRR QPVNRQGPVQ AICAYKQQGQ LQIEKGETVT LLDNSGRVKW RVRTAKGQEG 960
  961 PIPGACLLLP PPDQEAIDAA ERLKRLFDRS VALWQKKHLR LRQNMIFATI RVVKGWDFDQ1020
 1021 FLAMGPEQRT AIRRALNDDA DKLLSEGDPN DPQLRRLRRE MDEVNRLFDE FEKRARAEEE1080
 1081 SKQASRIFTE ECLAIKSKLE DMARELDQII LAPLPRDLDS LEHVLEIHSD YERRLHLLEP1140
 1141 ELKHLQETFR TIALKTPVLK KSLDNLMELW KELNTQSGLH KDRLKLLEAS LAGLEDNEHV1200
 1201 ISELENELAR HQDLPSTAEG LQQVFKQLNH MQDIITQQQP QMDKMNDAAD QLGRMGVPTK1260
 1261 VLGDLKRLHS NVERLNTRWS AVCNQLGERM RSCETAIGLM KNLQSSVQVE ESWVDGTTER1320
 1321 LSAMPTATSA YELDQAVFEK FNMCEENVND LLKWVTTVEQ KISSVGGPRE KIDELRNQIN1380
 1381 ALKQIKDEIE SQQRPVATCL EQIRQIVLTG GDVLSAPEVT TLENSGRELR SRVDRVNDRT1440
 1441 VRLLRRLEAG RDELTKLRSE LDVFSDWLQV ARRTLEDKER SLSDLTRLPS QADSVREFVS1500
 1501 DVIGHQADLR FITMAAQKFV DESKEFLAIL NDFRTSLPER LPHVEPLSSA ESPIRQEVSL1560
 1561 VSAQYKDLLN RVNALQDRVS GLGGRQREYQ DALDKANEWL RSVHPRVSRI ISEPIAGDPK1620
 1621 GVQDQMNEAK ALHNELLSSG RLVDNAQQAL DNLLRSLGGQ LSPMEINQLE LPIADLKNNY1680
 1681 QQLLDNLGEH CKTLDKTLVQ SQGVQDALDS LVGWVNQAED KFKMNLRPAS LIKERLQEQI1740
 1741 REHKVLLADL QSHQASIDSV QVSAKHLLAS ASNARIAKKV ESNLNDVTVK FEKLYEKANK1800
 1801 RGEFLDDVYN RLSRYLDEIS TVEQRMASLQ EALDSRETSL LSTEELARRM NELSRDKDQL1860
 1861 APQFEDCVRS GKDLISLRDV TDTGVLRDRI KALESQWRNI NISIDERAKL SKQKAEQQLA1920
 1921 YEGLKDQVLS WLASTEARVN GLPPVAIDLD RIKQQHDELK PICKDYRDYA PTIDKINDIG1980
 1981 AQYDALIRPE SPARKRSTYS PIKRTSPLRR MSGDARSPSP TKGGILSPLS TGSSGFGSRR2040
 2041 SSQDGFQLSE LSPVQQQLSE INNRYGLIGV RLNDRQHELD NLNEELRKQY ENLKGLAQFL2100
 2101 ERIQRQLPKE SVSNKDEAER CIKQARKILE DMYEKQSLLD TTKAQVKDIL RRKSDVPGAE2160
 2161 QLRQENDSIQ EKWKNLNDIC KNRIAFSEKL RDFLDTHGNL KSWLDSKERM LTVLGPISSD2220
 2221 PRMVQSQVQQ VQVLREEFRT QQPQLKHFQE LGHDVVDHLA GTPDAQAVEI KLKDILGKWD2280
 2281 DLVGKLDDRA NSLGGAADSS KEFDAAVNRL REALQNISDN LDTLPTDGDH QENLRKIENL2340
 2341 ERQLEGQRPL LADVEQSAAT LCNILGDPAS RADVNSRVAA LEKQYLALQK KLDTKKAETE2400
 2401 ASLRDGRHFA ENCSKTLGWL GGELSNLTDR LLVSAHKPTL QHQIDTHEPI YREVMAREHE2460
 2461 VIMLINKGKD LTDRQQDRGV KRDLDRIQQQ WEKLRREAVD RHTRLQTCME HCKKYSQTSE2520
 2521 TFLAWLRTAE DKLADLTPGV LSKAKLETRL RDLQTFRSEV WKHSGEFENT KGLGETFLSS2580
 2581 CDIDKEPIKA ELQDIRDRWE RLNNDLIARA HEIENCSRRL DDFNDELRNL DHSLGRCEDR2640
 2641 LAAHDALGGA AKDPKLLERV KAIREELTNL SKPLQSLKAL AKDISAEARA AGGDADHLTS2700
 2701 EVDGLADRMS ELQGRLDDRC GELQSAATAV SQFNEQMKSL GIDLNDLETE IEKLSPPGRE2760
 2761 IKIVQVQIDD VGKIQTKLDR LVGRLEDAER AADVLVDAGF AADTTQTREQ ISTLRKTLGR2820
 2821 LDNRVRDHED NLHSTLKALR EFYDHQSQTL DDIQDVSDEF KRMKPVGSEL DQIRRQQEDF2880
 2881 RNFRERKVEP LAINVDKVNV AGRDLVRSAG SGVSTTAIEK DLEKLNDRWN DLKERMNERD2940
 2941 RRLDVALLQS GKFQEALAGL SKWLSDTEEM VANQKPPSSD YKVVKAQLQE QKFLKKMLLD3000
 3001 RQNSMGSLAN LGKEVANHCE PGERASIEKQ LNDLMKRFDA LTDGAEQREL DLEEAMEVAK3060
 3061 RFHDKISPLE LWLDNTERSV KAMELIPTDE EKIQQRIREH DRLHDEILGK KPDFSDLADV3120
 3121 TAQLMHLVSD EEAVNLGEKV RGVTERYTGL VDASDNIGAL LAESRQGLRH LVLSYQDLVA3180
 3181 WMESMEAELK RFKSVPVYAE KLLEQMDHLL ELNENIAGHA SNVESTVESG AELMKHISND3240
 3241 EAIQLKDKLD SLQRRYGDLT NRGGDLLKSA QNALPLVQQF HEAHNRLVEW MQSAEAALAP3300
 3301 SEPRQADVLR LEGELADMRP ILDSINQVGP QLCQLSPGEG AATIESIVTR DNRRFDSIVE3360
 3361 QIQRKAERLH LSNQRAKEVT GDIDELLEWF REMDTTLREA DLPAMEPKLV RAQLQEHRSI3420
 3421 NDDISSQKGR VRDVTAASKK VLRESPQSEN TATLREKLDD LKEIVDTVAQ LCSERLGILE3480
 3481 QALPLSEHFA DSHQGLTAWL DDMEQQISRL SMPALRPDQI TLQQDKNERL LQSIAEHKPL3540
 3541 LDKLNKTGEA LGALVADDDG AKINEILDTD NARYAALRLE LRERQQALES ALQESSQFSD3600
 3601 KLEGMLRALA NTVDQVNQLD PLSALPQKIR EQIEDNDALM DDLDKRQDAF SAVQRAANDV3660
 3661 IAKAGNKADP AVRDIKAKLE KLNNLWNDVQ NATKKRGSSL DDILSVAEPF WKQLNSVMKT3720
 3721 LKDLEETLSC QEPPAAQPQD IKKQQVALQE IRHEIDQTKP EVEQVRRHGS NLMNMCGEPD3780
 3781 KPEVKKHIED LDNAWDNITA LYAKREENLI DAMEKAMEFH ETLQNLLKFL TKAEDKFAHL3840
 3841 GAVGSDIDAV KRQIEQLKSF KDEVDPHMVE VEALNRQAVE LTERTSPEQA ASIREPLSVV3900
 3901 NRRWEALLRG MVERQKQLEH ALLHLGQFQH ALNELLVWIN KTDSTLDQLK PIPGDPQLLE3960
 3961 VELAKLKVLA NDIQAHQNSV DTLNDAGRQL IETEKGSVEA STTQEKLRKL NNEWKQLLQK4020
 4021 ASDRQHELEE ALREAHGYIA EVQDILGWLG DVDAVIGASK PVGGLPETAT EQLERFMEVY4080
 4081 NELDENRPKV ETIQAQGQEY IKRQNQMKVS SSNLQHTLRT LKQRWDAVVS RASDKKIKLE4140
 4141 IALKEATEFH DTLQAFVEWL TQAEKLLSNA EPVSRVLETI QAQMEEHKVL QKDVSTHREA4200
 4201 MLLLDKKGTH LKYFSQKQDV ILIKNLLVSV QHRWERVVSK AAERTRALDH GYKEAREFND4260
 4261 AWSGMMQYLQ ETEQVLDQII EEATASKEPQ KIKKYIGKLK ETHRQLGAKQ SVYDGTMRTG4320
 4321 KNLLERAPKG DRPVLDKMLI ELKEQWTRVW SKSIDRQRKL EEALLLSGQF SDALGELLDW4380
 4381 LKKAKSRLNE NGPVHGDLET VQGLCEHHKH IEQDLQKRAA QMQGVLKTGR DLERSGNNPE4440
 4441 VGRQLDEMQS IWEEVKSAVA KRGERLQVAL VDAEKLNARV QALFDWLDHA EHKLRYAKNA4500
 4501 PDDEKVSREM MDIHMDFMKD LRVREREKTE TFEYAEDIIN KAYPDAIPII KNWLSIIQQR4560
 4561 WEEVRQWAIN RESKLEQHLQ SLKDLDDTIE ELLAWLSGLE GTLLNLKHEQ LPDEIPPVEK4620
 4621 LIEDHKEFME NTARRQNEVD RACKPRQLPP GARKPSRSGK TPVFKGSRDQ GLNARKGSRI4680
 4681 TPTRDTPDRD RLPHYGPRFS PSTSGPELEF RSPRAKLLWT KWRDVWMLSW ERQRLLNDHL4740
 4741 LYLKDVERAR NFSWDDWRKR FLKYMNHKKS RLTDLFRKMD KDNNGMIPRD VFIDGILNTK4800
 4801 FDTSGLEMKA VADLFDRNGE GLIDWQEFIA ALRPDWQERK PANDSDKIHD EVKRLVMLCT4860
 4861 CRQKFRVFQV GEGKYRFGDS QKLRLVRILR STVMVRVGGG WVALDEFLQK NDPCRAKGRT4920
 4921 NIELREQFIL ADGVSQSMAA FTPRRSTPNA AATASSSPHA HNGGSSNLPP YMSGQGPIIK4980
 4981 VRERSVRSIP MSRPSRSSLS ASTPDSLSDN EGSHGGPSGR YTPRKVTYTS TRTGLTPGGS5040
 5041 RAGSKPNSRP LSRQGSKPPS RHGSTLSLDS TDDHTPSRIP QRKPSTGSTA SGTTPRPARL5100
 5101 SVTTTTTPGS RLNGTSTITR KTASGSASPA PTSNGGMSRS SSIPALTGFG FKPIRRNISG5160
 5161 SSTPSGMQTP RKSSAEPTFS STMRRTSRGT TPTEKREPFR L

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

    No microscopy data found in the PDR for this protein.

    Protein Structure Data



    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle