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Protein Overview: shot-PB

General Information:
Name(s) found: shot-PB / FBpp0086742 [FlyBase]
Description(s) found:
Found 19 descriptions.
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  • The gene short stop is referred to in FlyBase by the symbol Dmel\shot (CG18076, FBgn0013733). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 2R:9751742..9829615. It has the cytological map location 50C6-50C9. There is experimental evidence that it has the molecular function</span>: protein binding. There is experimental evidence that it is involved in the biological process</span>: negative regulation of microtubule depolymerization; dendrite morphogenesis; oocyte fate determination; regulation of axon extension; microtubule cytoskeleton organization; mushroom body development; open tracheal system development; branch fusion, open tracheal system; lumen formation, open tracheal system; axon midline choice point recognition. 76 alleles are reported. The phenotypes of these alleles are annotated with 25 unique terms, many of which group under: organ system; multi-cell-component structure; peripheral nervous system; nervous system; anatomical structure; ectoderm derivative; embryonic/larval tracheal system; embryonic nervous system; portion of tissue; embryonic neuron. It has 15 annotated transcripts and 15 annotated polypeptides. [FlyBase]
    • Organism: Drosophila melanogaster
    Length: 5390 amino acids

    Gene Ontology:
    Cellular Component: growth cone [IDA]
    adherens junction [IDA][TAS]
    cytoskeleton [NAS]
    fusome [IDA]
    astral microtubule [IDA]
    microtubule [IDA][TAS]
    Biological Process: cell cycle arrest [IEA]
    mushroom body development [IMP]
    negative regulation of microtubule depolymerization [IMP]
    apposition of dorsal and ventral imaginal disc-derived wing surfaces [TAS]
    microtubule cytoskeleton organization [IMP][TAS]
    sensory organ development [TAS]
    microtubule-based process [ISS][NAS]
    dendrite morphogenesis [IMP][TAS]
    open tracheal system development [IMP][TAS]
    muscle organ development [NAS]
    regulation of axon extension [IMP]
    oocyte fate determination [IMP]
    axonogenesis [TAS]
    axon midline choice point recognition [IMP]
    branch fusion, open tracheal system [IEP][IMP][TAS]
    actin cytoskeleton organization [TAS]
    muscle attachment [NAS][TAS]
    lumen formation, open tracheal system [IMP]
    determination of muscle attachment site [TAS]
    Molecular Function: protein binding [IPI]
    actin binding [ISS][TAS]
    calcium ion binding [IEA]
    cytoskeletal protein binding [ISS]
    microtubule binding [ISS][TAS]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MMDRESLSEW AKDKPLSILQ LDPADRAVLR IADERDAIQK KTFTKWVNKH LKKANRRVVD  60
   61 LFEDLRDGHN LLSLLEVLSG EHLPREKGKM RFHMLQNAQM ALDFLRYKKI KLVNIRAEDI 120
  121 VDGNPKLTLG LIWTIILHFQ ISDIVVGKED NVSAREALLR WARRSTARYP GVRVNDFTSS 180
  181 WRDGLAFSAL VHRNRPDLLD WRKARNDRPR ERLETAFHIV EKEYGVTRLL DPEDVDTNEP 240
  241 DEKSLITYIS SLYDVFPEPP SIHPLFDMES QRRVHEYRDL AQQFIYWCRE KTAYLQERSF 300
  301 PPTLIEMKRL LSDLQRFRSD EVSARKREKS KLIQIYKELE RYFETVGEVD VEAELRPDAI 360
  361 EKAWYRMNTA LQDREVILQQ EIERLERLQR LADKVQREIK HVDQKLTDLE GRIGEEGRRI 420
  421 ERLHPVDAKS IVEALETEIR HLEEPIQDMN QDCHVLNEGR YPHVSELHKK VNKLHQRWAQ 480
  481 LRTNFHTNLV QKLSGLKYPV HETTVTRQTR MVVESRQIDT NPHFRDLQEH IEWCQNKLKQ 540
  541 LLAADYGSDL PSVKEELDRQ QHEHKIIDQF HTKILNDERQ QTKFSGDELA LYQQRLNQLQ 600
  601 KVYAELLSTS TKRLSDLDSL QHFLGQASAE LQWLNEKEQV EITRDWADKQ LDLPSVHRYY 660
  661 ENLMSELEKR EMHFATILDR GEALLNQQHP ASKCIEAHLT ALQQQWAWLL QLTLCLEVHL 720
  721 KHATEYHQFF GEIKDAEQWL AKRDEILNSK FSQSDFGLDQ GETLLRGMQD LREELNAFGE 780
  781 TVATLQRRAQ TVVPLNKRRQ PVNRQGPVQA ICAYKQQGQL QIEKGETVTL LDNSGRVKWR 840
  841 VRTAKGQEGP IPGACLLLPP PDQEAIDAAE RLKRLFDRSV ALWQKKHLRL RQNMIFATIR 900
  901 VVKGWDFDQF LAMGPEQRTA IRRALNDDAD KLLSEGDPND PQLRRLRREM DEVNRLFDEF 960
  961 EKRARAEEES KQASRIFTEE CLAIKSKLED MARELDQIIL APLPRDLDSL EHVLEIHSDY1020
 1021 ERRLHLLEPE LKHLQETFRT IALKTPVLKK SLDNLMELWK ELNTQSGLHK DRLKLLEASL1080
 1081 AGLEDNEHVI SELENELARH QDLPSTAEGL QQVFKQLNHM QDIITQQQPQ MDKMNDAADQ1140
 1141 LGRMGVPTKV LGDLKRLHSN VERLNTRWSA VCNQLGERMR SCETAIGLMK NLQSSVQVEE1200
 1201 SWVDGTTERL SAMPTATSAY ELDKLLGAAI ERKPKIENVN VAGGRLIREA KIYDSKCLRF1260
 1261 VDWLVEARPS FSPPRRDLRP ADSDPGATQY YSQRLDNLNT KNDRLLEQLS QRLKTAIEVN1320
 1321 GSDGLQYAES LQKPLKTFRV DFSAGSVPTG DGYAARQEDL YTTTYSTTQI SSTKTTKSST1380
 1381 KSVYSSDGLD AASQEVSTAG LPQSQIQFNE IRTLKRSQQL GGHSVLDIAG IRDPRTGRVL1440
 1441 TIGEAIQLRI LDVRTGEMLV GDRRITLEQA ADQGLIDLQL AKQLLEPGAG RDASGRELSL1500
 1501 LEVIQREISE AESGYETAEK RIKQAVFEKF NMCEENVNDL LKWVTTVEQK ISSVGGPREK1560
 1561 IDELRNQINA LKQIKDEIES QQRPVATCLE QIRQIVLTGG DVLSAPEVTT LENSGRELRS1620
 1621 RVDRVNDRTV RLLRRLEAGR DELTKLRSEL DVFSDWLQVA RRTLEDKERS LSDLTRLPSQ1680
 1681 ADSVREFVSD VIGHQADLRF ITMAAQKFVD ESKEFLAILN DFRTSLPERL PHVEPLSSAE1740
 1741 SPIRQEVSLV SAQYKDLLNR VNALQDRVSG LGGRQREYQD ALDKANEWLR SVHPRVSRII1800
 1801 SEPIAGDPKG VQDQMNEAKA LHNELLSSGR LVDNAQQALD NLLRSLGGQL SPMEINQLEL1860
 1861 PIADLKNNYQ QLLDNLGEHC KTLDKTLVQS QGVQDALDSL VGWVNQAEDK FKMNLRPASL1920
 1921 IKERLQEQIR EHKVLLADLQ SHQASIDSVQ VSAKHLLASA SNARIAKKVE SNLNDVTVKF1980
 1981 EKLYEKANKR GEFLDDVYNR LSRYLDEIST VEQRMASLQE ALDSRETSLL STEELARRMN2040
 2041 ELSRDKDQLA PQFEDCVRSG KDLISLRDVT DTGVLRDRIK ALESQWRNIN ISIDERAKLS2100
 2101 KQKAEQQLAY EGLKDQVLSW LASTEARVNG LPPVAIDLDR IKQQHDELKP ICKDYRDYAP2160
 2161 TIDKINDIGA QYDALIRPES PARKRSTYSP IKRTSPLRRM SGDARSPSPT KGGILSPLST2220
 2221 GSSGFGSRRS SQDGFQLSEL SPVQQQLSEI NNRYGLIGVR LNDRQHELDN LNEELRKQYE2280
 2281 NLKGLAQFLE RIQRQLPKES VSNKDEAERC IKQARKILED MYEKQSLLDT TKAQVKDILR2340
 2341 RKSDVPGAEQ LRQENDSIQE KWKNLNDICK NRIAFSEKLR DFLDTHGNLK SWLDSKERML2400
 2401 TVLGPISSDP RMVQSQVQQV QVLREEFRTQ QPQLKHFQEL GHDVVDHLAG TPDAQAVEIK2460
 2461 LKDILGKWDD LVGKLDDRAN SLGGAADSSK EFDAAVNRLR EALQNISDNL DTLPTDGDHQ2520
 2521 ENLRKIENLE RQLEGQRPLL ADVEQSAATL CNILGDPASR ADVNSRVAAL EKQYLALQKK2580
 2581 LDTKKAETEA SLRDGRHFAE NCSKTLGWLG GELSNLTDRL LVSAHKPTLQ HQIDTHEPIY2640
 2641 REVMAREHEV IMLINKGKDL TDRQQDRGVK RDLDRIQQQW EKLRREAVDR HTRLQTCMEH2700
 2701 CKKYSQTSET FLAWLRTAED KLADLTPGVL SKAKLETRLR DLQTFRSEVW KHSGEFENTK2760
 2761 GLGETFLSSC DIDKEPIKAE LQDIRDRWER LNNDLIARAH EIENCSRRLD DFNDELRNLD2820
 2821 HSLGRCEDRL AAHDALGGAA KDPKLLERVK AIREELTNLS KPLQSLKALA KDISAEARAA2880
 2881 GGDADHLTSE VDGLADRMSE LQGRLDDRCG ELQSAATAVS QFNEQMKSLG IDLNDLETEI2940
 2941 EKLSPPGREI KIVQVQIDDV GKIQTKLDRL VGRLEDAERA ADVLVDAGFA ADTTQTREQI3000
 3001 STLRKTLGRL DNRVRDHEDN LHSTLKALRE FYDHQSQTLD DIQDVSDEFK RMKPVGSELD3060
 3061 QIRRQQEDFR NFRERKVEPL AINVDKVNVA GRDLVRSAGS GVSTTAIEKD LEKLNDRWND3120
 3121 LKERMNERDR RLDVALLQSG KFQEALAGLS KWLSDTEEMV ANQKPPSSDY KVVKAQLQEQ3180
 3181 KFLKKMLLDR QNSMGSLANL GKEVANHCEP GERASIEKQL NDLMKRFDAL TDGAEQRELD3240
 3241 LEEAMEVAKR FHDKISPLEL WLDNTERSVK AMELIPTDEE KIQQRIREHD RLHDEILGKK3300
 3301 PDFSDLADVT AQLMHLVSDE EAVNLGEKVR GVTERYTGLV DASDNIGALL AESRQGLRHL3360
 3361 VLSYQDLVAW MESMEAELKR FKSVPVYAEK LLEQMDHLLE LNENIAGHAS NVESTVESGA3420
 3421 ELMKHISNDE AIQLKDKLDS LQRRYGDLTN RGGDLLKSAQ NALPLVQQFH EAHNRLVEWM3480
 3481 QSAEAALAPS EPRQADVLRL EGELADMRPI LDSINQVGPQ LCQLSPGEGA ATIESIVTRD3540
 3541 NRRFDSIVEQ IQRKAERLHL SNQRAKEVTG DIDELLEWFR EMDTTLREAD LPAMEPKLVR3600
 3601 AQLQEHRSIN DDISSQKGRV RDVTAASKKV LRESPQSENT ATLREKLDDL KEIVDTVAQL3660
 3661 CSERLGILEQ ALPLSEHFAD SHQGLTAWLD DMEQQISRLS MPALRPDQIT LQQDKNERLL3720
 3721 QSIAEHKPLL DKLNKTGEAL GALVADDDGA KINEILDTDN ARYAALRLEL RERQQALESA3780
 3781 LQESSQFSDK LEGMLRALAN TVDQVNQLDP LSALPQKIRE QIEDNDALMD DLDKRQDAFS3840
 3841 AVQRAANDVI AKAGNKADPA VRDIKAKLEK LNNLWNDVQN ATKKRGSSLD DILSVAEPFW3900
 3901 KQLNSVMKTL KDLEETLSCQ EPPAAQPQDI KKQQVALQEI RHEIDQTKPE VEQVRRHGSN3960
 3961 LMNMCGEPDK PEVKKHIEDL DNAWDNITAL YAKREENLID AMEKAMEFHE TLQNLLKFLT4020
 4021 KAEDKFAHLG AVGSDIDAVK RQIEQLKSFK DEVDPHMVEV EALNRQAVEL TERTSPEQAA4080
 4081 SIREPLSVVN RRWEALLRGM VERQKQLEHA LLHLGQFQHA LNELLVWINK TDSTLDQLKP4140
 4141 IPGDPQLLEV ELAKLKVLAN DIQAHQNSVD TLNDAGRQLI ETEKGSVEAS TTQEKLRKLN4200
 4201 NEWKQLLQKA SDRQHELEEA LREAHGYIAE VQDILGWLGD VDAVIGASKP VGGLPETATE4260
 4261 QLERFMEVYN ELDENRPKVE TIQAQGQEYI KRQNQMKVSS SNLQHTLRTL KQRWDAVVSR4320
 4321 ASDKKIKLEI ALKEATEFHD TLQAFVEWLT QAEKLLSNAE PVSRVLETIQ AQMEEHKVLQ4380
 4381 KDVSTHREAM LLLDKKGTHL KYFSQKQDVI LIKNLLVSVQ HRWERVVSKA AERTRALDHG4440
 4441 YKEAREFNDA WSGMMQYLQE TEQVLDQIIE EATASKEPQK IKKYIGKLKE THRQLGAKQS4500
 4501 VYDGTMRTGK NLLERAPKGD RPVLDKMLIE LKEQWTRVWS KSIDRQRKLE EALLLSGQFS4560
 4561 DALGELLDWL KKAKSRLNEN GPVHGDLETV QGLCEHHKHI EQDLQKRAAQ MQGVLKTGRD4620
 4621 LERSGNNPEV GRQLDEMQSI WEEVKSAVAK RGERLQVALV DAEKLNARVQ ALFDWLDHAE4680
 4681 HKLRYAKNAP DDEKVSREMM DIHMDFMKDL RVREREKTET FEYAEDIINK AYPDAIPIIK4740
 4741 NWLSIIQQRW EEVRQWAINR ESKLEQHLQS LKDLDDTIEE LLAWLSGLEG TLLNLKHEQL4800
 4801 PDEIPPVEKL IEDHKEFMEN TARRQNEVDR ACKPRQLPPG ARKPSRSGKT PVFKGSRDQG4860
 4861 LNARKGSRIT PTRDTPDRDR LPHYGPRFSP STSGPELEFR SPRAKLLWTK WRDVWMLSWE4920
 4921 RQRLLNDHLL YLKDVERARN FSWDDWRKRF LKYMNHKKSR LTDLFRKMDK DNNGMIPRDV4980
 4981 FIDGILNTKF DTSGLEMKAV ADLFDRNGEG LIDWQEFIAA LRPDWQERKP ANDSDKIHDE5040
 5041 VKRLVMLCTC RQKFRVFQVG EGKYRFGDSQ KLRLVRILRS TVMVRVGGGW VALDEFLQKN5100
 5101 DPCRAKGRTN IELREQFILA DGVSQSMAAF TPRRSTPNAA ATASSSPHAH NGGSSNLPPY5160
 5161 MSGQGPIIKV RERSVRSIPM SRPSRSSLSA STPDSLSDNE GSHGGPSGRY TPRKVTYTST5220
 5221 RTGLTPGGSR AGSKPNSRPL SRQGSKPPSR HGSTLSLDST DDHTPSRIPQ RKPSTGSTAS5280
 5281 GTTPRPARLS VTTTTTPGSR LNGTSTITRK TASGSASPAP TSNGGMSRSS SIPALTGFGF5340
 5341 KPIRRNISGS STPSGMQTPR KSSAEPTFSS TMRRTSRGTT PTEKREPFRL

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

    No microscopy data found in the PDR for this protein.

    Protein Structure Data



    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle