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Protein Overview: NAT1-PA, NAT1-PB

General Information:
Name(s) found: NAT1-PB / FBpp0086900 [FlyBase]
NAT1-PA / FBpp0086899 [FlyBase]
Description(s) found:
Found 33 descriptions.
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  • The gene NAT1 is referred to in FlyBase by the symbol Dmel\NAT1 (CG3845, FBgn0010488). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 2R:8803502..8810745. It has the cytological map location 49E1. Based on sequence similarity, it is predicted to have molecular function</span>: translation initiation factor activity. There is experimental evidence that it is involved in the biological process</span>: autophagic cell death; salivary gland cell autophagic cell death. 8 alleles are reported. No phenotypic data is available. It has 3 annotated transcripts and 3 annotated polypeptides. [FlyBase]
  • The gene NAT1 is referred to in FlyBase by the symbol Dmel\NAT1 (CG3845, FBgn0010488). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 2R:8803502..8810745. It has the cytological map location 49E1. Based on sequence similarity, it is predicted to have molecular function</span>: translation initiation factor activity. There is experimental evidence that it is involved in the biological process</span>: autophagic cell death; salivary gland cell autophagic cell death. 8 alleles are reported. No phenotypic data is available. It has 3 annotated transcripts and 3 annotated polypeptides. [FlyBase]
    • Organism: Drosophila melanogaster
    Length: 918 amino acids

    Gene Ontology:
    Cellular Component: mRNA cap binding complex [ISS]
    Biological Process: RNA metabolic process [IEA]
    autophagic cell death [IEP]
    salivary gland cell autophagic cell death [IEP]
    Molecular Function: translation initiation factor activity [ISS]
    protein binding [IEA]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MYAQLCKRLS EEAPSFDKEP SNSSTFLRLL IAVCRDKFNN RLKRDENDNR PPPENEADEE  60
   61 ERRHLAKQRM LGNVKFIGEL NKLDMLSKNV LHQCIMELFD KKKKRTAGTQ EMCEDMECLA 120
  121 QLLKTCGKNL DSEQGKELMN QYFEKLERRS KSSEYPPRIR FMLKDVIELR QNNWVPRKLG 180
  181 TTEGPVPIKQ IRSDDDSIIR TPFPNRNRDM RNNDRDSDSW MNRFHLNIQP GGYNDMFSGL 240
  241 SVTGASPIVS PFATSNRDRD RDNRQYNNRG DRNRDRDQGG SGGANYGNRY NKHNQNGGGS 300
  301 GGGSSNNRDR DDSRRNNDRD RDRNDGQYGG NQLLGSKELA PRFKRNLITT NQDAVENLQM 360
  361 RPAANSLLFR AASQNQKFPA TLPMSTPPNS SGSNNQGSSQ GQLSNSHYPM LGTPTSHLIN 420
  421 PTRPSSTPSA EYADNRTLLG VQQERGLKAT SSSPNFSSGA EKLDLDGQAG RKGSHDGKDQ 480
  481 GKNGSVERPS TPAGGIGSAK QQKKDKGPNK EELSKKASQY FKDRFYYDEE EDAEVTEIEI 540
  541 KDIDETKTEE ADAAPVEVSE VKEDAAIPVT TPDRFTKLVD GFLELKLPEK ALKDVCINLL 600
  601 MEVLDRVNDV FLERAVRLLQ TLRKQSNIKP NIVVEIFKQV VNKMNEREAL NPRIVSLVAS 660
  661 LLAKTICEPA LLKLSDIANF TDNGQHYPLF LLVLQQLVKV IGKDALEEKF RASKVDLMNS 720
  721 LPEADRNKER LAGILEDRKL SFLYPLLKVQ AEMLKQLQSD PNPNNFYKWI KANVDNKYYK 780
  781 DPGFIQALMT VVVKYVTKET TLADNLDPKE HPEKSVTQKE QQLLENYSQM LQTFLGQNEL 840
  841 QLMALYALQT FCYNENFPKG MLCRWFKYLY ESEIIEEEAF VLWKEEISDK YPGKGSALFQ 900
  901 VNAWLTWLQE AESEDDED

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..153] PSI-BLAST 66.39794 Eukaryotic initiation factor eIF4G
    2 View Details [154..579] PSI-BLAST 28.522879 No description for 1y0fB was found.
    3 View Details [580..918] PSI-BLAST 101.0 C-terminal portion of human eIF4GI

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • RNA cap binding
    		•  3.2160251815809 bayes_pls_golite062009
  • binding
    		•  1.99013774955562 bayes_pls_golite062009
  • protein binding
    		•  1.75981610748679 bayes_pls_golite062009
    2 No functions predicted.
    3 No functions predicted.


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.98

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle