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Protein Overview: Lac-PA

General Information:
Name(s) found: Lac-PA / FBpp0087044 [FlyBase]
Description(s) found:
Found 24 descriptions.
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  • The gene Lachesin is referred to in FlyBase by the symbol Dmel\Lac (CG12369, FBgn0010238). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 2R:8340696..8353154. It has the cytological map location 49A6-49A7. Its molecular function is unknown. There is experimental evidence that it is involved in the biological process</span>: morphogenesis of embryonic epithelium; homophilic cell adhesion; regulation of tube size, open tracheal system; maintenance of epithelial integrity, open tracheal system; open tracheal system development. 12 alleles are reported. The phenotypes of these alleles are annotated with: embryonic dorsal trunk; embryonic salivary gland; embryonic dorsal group branch; embryonic/larval dorsal trunk; embryonic tracheal system; embryonic/larval tracheal system; embryonic lateral group branch; embryonic/larval transverse connective. It has 2 annotated transcripts and 2 annotated polypeptides. [FlyBase]
    • Organism: Drosophila melanogaster
    Length: 359 amino acids

    Gene Ontology:
    Cellular Component: septate junction [IDA]
    extrinsic to membrane [NAS]
    Biological Process: regulation of tube size, open tracheal system [IMP]
    axonogenesis [ISS]
    morphogenesis of embryonic epithelium [IMP]
    homophilic cell adhesion [IDA]
    maintenance of epithelial integrity, open tracheal system [IMP]
    open tracheal system development [IEP][IMP]
    Molecular Function: NONE FOUND


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MWRPSISNCV WSTLLLAIFV QQTLAQRTPT ISYITQEQIK DIGGTVEFDC SVQYAKEYNV  60
   61 LFLKTDSDPV FLSTGSTLVI KDSRFSLRYD PNSSTYKLQI KDIQETDAGT YTCQVVISTV 120
  121 HKVSAEVKLS VRRPPVISDN STQSVVASEG SEVQMECYAS GYPTPTITWR RENNAILPTD 180
  181 SATYVGNTLR IKSVKKEDRG TYYCVADNGV SKGDRRNINV EVEFAPVITV PRPRLGQALQ 240
  241 YDMDLECHIE AYPPPAIVWT KDDIQLANNQ HYSISHFATA DEYTDSTLRV ITVEKRQYGD 300
  301 YVCKATNRFG EAEARVNLFE TIIPVCPPAC GQAYIAGAED VSATSFALVG ILAALLFAR

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    SHOWING SINGLE HITS. [ Hide Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..359] PSI-BLAST 44.0 Axonin-1

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • binding
    		•  2.33804459527604 bayes_pls_golite062009
  • receptor activity
    		•  1.90298241148243 bayes_pls_golite062009
  • signal transducer activity
    		•  1.59395248964472 bayes_pls_golite062009
  • molecular transducer activity
    		•  1.59395248964472 bayes_pls_golite062009
  • transmembrane receptor activity
    		•  1.5023290800351 bayes_pls_golite062009
  • fibroblast growth factor 1 binding
    		•  1.39482409678992 bayes_pls_golite062009
  • cell adhesion molecule binding
    		•  1.36789541796983 bayes_pls_golite062009
  • fibroblast growth factor receptor activity
    		•  1.13671712991988 bayes_pls_golite062009
  • protein binding
    		•  1.0782734177126 bayes_pls_golite062009
  • fibroblast growth factor binding
    		•  0.646668003618218 bayes_pls_golite062009
  • integrin binding
    		•  0.599569390248921 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    [View Details]
    Source: Reynolds et al. 2008. Manuscript submitted Philius confidence legend
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