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Protein Overview: RpIII128-PA

General Information:
Name(s) found: RpIII128-PA / FBpp0087085 [FlyBase]
Description(s) found:
Found 22 descriptions.
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  • The gene RNA polymerase III 128kD subunit is referred to in FlyBase by the symbol Dmel\RpIII128 (CG8344, FBgn0004463). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 2R:7926595..7930138. It has the cytological map location 48D8. Based on sequence similarity, it is predicted to have molecular function</span>: DNA-directed RNA polymerase activity. Based on sequence similarity, it is predicted to be involved in the biological process</span>: transcription from RNA polymerase III promoter. One allele is reported. No phenotypic data is available. It has one annotated transcript and one annotated polypeptide. [FlyBase]
    • Organism: Drosophila melanogaster
    Length: 1137 amino acids

    Gene Ontology:
    Cellular Component: nucleus [NAS]
    DNA-directed RNA polymerase III complex [ISS]
    Biological Process: transcription from RNA polymerase III promoter [ISS][NAS]
    transcription [IEA]
    Molecular Function: DNA binding [IEA]
    DNA-directed RNA polymerase activity [ISS]
    ribonucleoside binding [IEA]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MVELKMGDHN VEATTWDPGD SKDWSVPIKP LTEKWKLVPA FLQVKGLVKQ HIDSFNHFIN  60
   61 VDIKKIVKAN ELVTSGADPL FYLKYLDVRV GKPDIDDGFN ITKATTPHEC RLRDTTYSAP 120
  121 ITVDIEYTRG TQRIKRNNLL IGRMPLMLRC SNCALTGKSE FELSKLNECP LDPGGYFVVR 180
  181 GQEKVILIQE QLSWNKMLTE DFNGVVQCQV TSSTHEKKSR TLVLSKHGKY YLKHNSMTDD 240
  241 IPIVVIFKAL GVVSDQEIQS LIGIDSKSQN RFGASLIDAY NLKVFTQQRA LEYMGSKLVV 300
  301 KRFQSATTKT PSEEARELLL TTILAHVPVD NFNLQMKAIY VSMMVRRVMA AELDKTLFDD 360
  361 RDYYGNKRLE LAGSLLSMMF EDLFKRMNWE LKTIADKNIP KVKAAQFDVV KHMRAAQITA 420
  421 GLESAISSGN WTIKRFKMER AGVTQVLSRL SYISALGMMT RVNSQFEKTR KVSGPRSLQP 480
  481 SQWGMLCPSD TPEGEACGLV KNLALMTHIT TEVEERPVMI VAFNAGVEDI REVSGNPINN 540
  541 PNVFLVFING NVLGLTLNHK HLVRNLRYMR RKGRMGSYVS VHTSYTQRCI YIHTDGGRLC 600
  601 RPYVIVENRR PLVKQHHLDE LNRGIRKFDD FLLDGLIEYL DVNEENDSFI AWNEDQIEDR 660
  661 TTHLEIEPFT LLGVCAGLVP YPHHNQSPRN TYQCAMGKQA MGMIGYNQKN RIDSLMYNLV 720
  721 YPHAPMVKSK TIELTNFDKL PAGQNATVAV MSYSGYDIED ALILNKASID RGYGRCLVYK 780
  781 NSKCTVKRYA NQTFDRIMGP MKDALTNKVI FKHDVLDTDG IVAPGEQVQN KQIMINKEMP 840
  841 AVTSMNPLQG QSAQVPYTAV PISYKGPEPS YIERVMVSAN AEEDFLIKIL LRQTRIPEIG 900
  901 DKFSSRHGQK GVTGLIVEQE DMPFNDFGIC PDMIMNPHGF PSRMTVGKTL ELLGGKAGLL 960
  961 EGKFHYGTAF GGSKVEDIQA ELERHGFNYV GKDFFYSGIT GTPLEAYIYS GPVYYQKLKH1020
 1021 MVQDKMHARA RGPKAVLTRQ PTQGRSREGG LRLGEMERDC LISYGASMLI MERLMISSDA1080
 1081 FEVDVCRTCG RMAYCSWCHF CQSSANVSKI SMPYACKLLF QELTSMNVVP KMILENY

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..1137] PSI-BLAST 1000.0 RBP2

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • DNA-directed RNA polymerase activity
    		•  10.2021663255698 bayes_pls_golite062009
  • RNA polymerase activity
    		•  10.2021663255698 bayes_pls_golite062009
  • nucleotidyltransferase activity
    		•  7.6240729546188 bayes_pls_golite062009
  • general RNA polymerase II transcription factor activity
    		•  6.31198922553685 bayes_pls_golite062009
  • transferase activity, transferring phosphorus-containing groups
    		•  5.44374972993429 bayes_pls_golite062009
  • transferase activity
    		•  4.83218811360621 bayes_pls_golite062009
  • transcription regulator activity
    		•  2.34884279395902 bayes_pls_golite062009
  • nucleic acid binding
    		•  2.33174616086951 bayes_pls_golite062009
  • DNA binding
    		•  2.27079409864244 bayes_pls_golite062009
  • binding
    		•  1.73416306650822 bayes_pls_golite062009
  • RNA polymerase II transcription mediator activity
    		•  1.53259746846673 bayes_pls_golite062009
  • catalytic activity
    		•  1.36406839864424 bayes_pls_golite062009
  • RNA binding
    		•  1.12618950637766 bayes_pls_golite062009
  • RNA polymerase II transcription factor activity
    		•  0.847783043631028 bayes_pls_golite062009
  • protein binding
    		•  0.45174975126993 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.98

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle