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Protein Overview: MCPH1-PB

General Information:
Name(s) found: MCPH1-PB / FBpp0290644 [FlyBase]
Description(s) found:
Found 21 descriptions.
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  • The gene Microcephalin is referred to in FlyBase by the symbol Dmel\MCPH1 (CG42572, FBgn0260959). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 2R:7783499..7791429. It has the cytological map location 48C5. Its molecular function is unknown. There is experimental evidence that it is involved in the biological process</span>: mushroom body development. 11 alleles are reported. No phenotypic data is available. It has 4 annotated transcripts and 4 annotated polypeptides. [FlyBase]
    • Organism: Drosophila melanogaster
    Length: 826 amino acids

    Gene Ontology:
    Cellular Component: nucleus [IDA]
    Biological Process: embryonic development [IMP]
    mushroom body development [IMP]
    pole cell formation [IMP]
    mitosis [IMP]
    Molecular Function: molecular_function [ND]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MDKFLLRNPT WKTKTYGSVV ASSAAAAKKT AASSTRRPLH DSNLGDFRSK AAAPSPKSLS  60
   61 QAPADDQAAR DRLMLKPALA VSKAISQHRS EFHQDENEAG AEGSAAKPDP PIGAATPTRQ 120
  121 EGHWARLQQD LNSPNAALRL RAIRALKSPT KSAYNTFDVP LAEQSIITME ERNPQEPPSL 180
  181 PELLKDIVVY VEVRTGNDNR SEGVKSIIAK MGAQVKDRLT RTTTHVVFKD GLLSTYKKAT 240
  241 EWNIPVVSIL WIEACKVQLK ICDPKQFPIS NIRMYEYPEL FGKMPRVKFM QPDSELNQRP 300
  301 RKRQGTPTSS KDNEPGSTNK RAQTGTPTTT TPKNDISRFF RAINHNKPSD DEAIESPATK 360
  361 LLNRISSGCY TPLPAGGTPQ LMGTNGSGDA VAQKVQAQKS LQFGEQTDSN TPQAKPSSTS 420
  421 RPRRSTVDPP PVMTPPVRTT RRRSCVAEIS SPAATDTRMT RRRSSLLTST VIHEADPTQT 480
  481 AVAEPRMTRR RSSLLGIAKQ AEETAQRQTI QPITEELAPV EENRNSIIMA ETNIINNTNC 540
  541 LEQSIEITAV EAEASFKADR RGTLYASELM DISSPRRRSV AKSSLELRQE NLAPRARQSL 600
  601 SNVTTQTSFL DVEQQVTPLF SSTRLPTGQT TGNRRRTIFN MDMDVINESI ERMNQSHRMS 660
  661 LALANKAELG ESCQVHEQEP PQAEPVPSQE PKRRRLFNPN DEVVISPAMS NRKSRLSITG 720
  721 SGSSSSVQKR RRSLATPAKS SSSELCATTP LSKAVTNKEA EKSKSNTEIS EASLDAVPEV 780
  781 KKSTSNAGEE NEKPKGKSRT RIRTLVHTNM HQEQINVIRK VGNTTE

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    SHOWING SINGLE HITS. [ Hide Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


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    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..111] deduced N/A No confident structure predictions are available.
    2 View Details [112..291] FFAS03 3.99 No description for 2d8mA was found.
    3 View Details [292..517] deduced N/A No confident structure predictions are available.
    4 View Details [518..697] MSA 2.218982 View MSA. No confident structure predictions are available.
    5 View Details [698..826] MSA 1.193986 View MSA. No confident structure predictions are available.


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    [View Details]
    Source: Reynolds et al. 2008. Manuscript submitted Philius confidence legend
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