YRC Logo
PROTEIN SEARCH:
Descriptions Names[Advanced Search]

Protein Overview: Vhl-PA, FBpp0304693

General Information:
Name(s) found: FBpp0304693 [FlyBase]
Vhl-PA / FBpp0087216 [FlyBase]
Description(s) found:
SHOW ONLY BEST
  • gi|74867035|sp|Q9V3C1.1|VHL_DROME RecName: Full=Protein Vhl [NCBI NR]
  • gi|73853435|gb|AAZ86788.1| IP02669p [Drosophila melanogaster] [NCBI NR]
  • gi|7303632|gb|AAF58684.1| von Hippel-Lindau [Drosophila melanogaster] [NCBI NR]
  • gi|6842048|gb|AAF29377.1|AF195836_1 von Hippel-Lindau tumor suppressor VHL [Drosophila melanogaster] [NCBI NR]
  • pir||JC7399 von Hippel-Lindau protein - fruit fly (Drosophila melanogaster) [NCBI NR]
  • gi|18447602|gb|AAL68362.1| RH61560p [Drosophila melanogaster] [NCBI NR]
  • gi|17864658|ref|NP_524986.1| von Hippel-Lindau [Drosophila melanogaster] [NCBI NR]
  • Protein Vhl OS=Drosophila melanogaster GN=Vhl PE=1 SV=1 [Swiss-Prot]
  • type=protein; loc=2R:7167383..7167919; ID=FBpp0304693; name=Vhl-PB; parent=FBgn0041174,FBtr0332420; dbxref=FlyBase:FBpp0304693,FlyBase_Annotation_IDs:CG13221-PB,REFSEQ:NP_001260885,GB_protein:AGB93418; MD5=4f4556dd59a240a6e0199b7136c95efb; length=178; release=r5.56; species=Dmel; [FlyBase]
  • The gene von Hippel-Lindau is referred to in FlyBase by the symbol Dmel\Vhl (CG13221, FBgn0041174). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 2R:7167231..7168538. It has the cytological map location 47E5-47E6. There is experimental evidence that it has the molecular function</span>: protein binding; ubiquitin-protein ligase activity. There is experimental evidence that it is involved in the biological process</span>: cytoskeleton organization; open tracheal system development; protein ubiquitination. 4 alleles are reported. The phenotypes of these alleles are annotated with: embryonic dorsal trunk; embryonic visceral branch; embryonic tracheal system; embryonic lateral trunk; embryonic transverse connective. It has one annotated transcript and one annotated polypeptide. [FlyBase]
  • >CG13221-PA translation from_gene[CG13221 Vhl FBgn0041174] seq_release:3 mol_weight=21241 cds_boundaries:(2R:6,344,607..6,345,140[+]) aa_length:178 transcript_info:[CG13221-RA seq_release:3] gene_info:[gene symbol:Vhl FBgn0041174 gene_boundaries:(2R:6, [hmr_yeast5_DM3-1_pombe.fasta]
  • (Q9V3C1) CG13221 protein (RH61560p) [DrosMelano7227.FASTAC.txt]
  • (AE003826) vhl gene product [Drosophila melanogaster] [yeastflysequest.fasta]
  • CG13221-PA [Drosophila melanogaster]gi|6842048|gb|AAF29377.1| von Hippel-Lindau tumor suppressor VHL [Drosophila melanogaster]gi|18447602|gb|AAL68362.1| RH61560p [Drosophila melanogaster]gi|17864658|ref|NP_524986.1| CG13221-PA [Drosophila melanogaster] [nrdb_11152004_Chlamydomonas]
  • type=protein; loc=2R:7167383..7167919; ID=FBpp0087216; name=Vhl-PA; parent=FBgn0041174,FBtr0088115; dbxref=FlyBase:FBpp0087216,FlyBase_Annotation_IDs:CG13221-PA,GB_protein:AAF58684.1,REFSEQ:NP_524986,GB_protein:AAF58684; MD5=4f4556dd59a240a6e0199b7136c95e [fly-100309-contam.fasta]
  • CG13221-PA [Drosophila melanogaster] [nr-271106-contam.fasta]
  • RH61560p [Drosophila melanogaster] [nr-271106-contam.fasta]
  • von Hippel-Lindau tumor suppressor VHL [Drosophila melanogaster] [nr-271106-contam.fasta]
  • Protein Vhl [nr-271106-contam.fasta]
  • von Hippel-Lindau CG13221-PA [Drosophila melanogaster] [nr-271106-contam.fasta]
  • IP02669p [Drosophila melanogaster] [nr-271106-contam.fasta]
  • type=protein; loc=2R:7167383..7167919; ID=FBpp0087216; name=Vhl-PA; parent=FBgn0041174,FBtr0088115; dbxref=FlyBase:FBpp0087216,FlyBase_Annotation_IDs:CG13221-PA,GB_protein:AAF58684.1,REFSEQ:NP_524986,GB_protein:AAF58684; MD5=4f4556dd59a240a6e0199b7136c95efb; length=178; release=r5.16; species=Dmel; [fly-contam-His-TEV-Tub4complex.fasta]
  • type=protein; loc=2R:7167383..7167919; ID=FBpp0087216; name=Vhl-PA; parent=FBgn0041174,FBtr0088115; dbxref=FlyBase:FBpp0087216,FlyBase_Annotation_IDs:CG13221-PA,GB_protein:AAF58684.1,REFSEQ:NP_524986,GB_protein:AAF58684; MD5=4f4556dd59a240a6e0199b7136c95efb; length=178; release=r5.21; species=Dmel; [Other_drosophila_na_09-09-2009_reversed.fasta]
  • type=protein; loc=2R:7167383..7167919; ID=FBpp0087216; name=Vhl-PA; parent=FBgn0041174,FBtr0088115; dbxref=FlyBase:FBpp0087216,FlyBase_Annotation_IDs:CG13221-PA,GB_protein:AAF58684.1,REFSEQ:NP_524986,GB_protein:AAF58684,FlyMine:FBpp0087216,modMine:FBpp0087216; MD5=4f4556dd59a240a6e0199b7136c95efb; length=178; release=r5.46; species=Dmel; [fly-062812-sfps-sandra-contam.fasta]
  • type=protein; loc=2R:7167383..7167919; ID=FBpp0304693; name=Vhl-PB; parent=FBgn0041174,FBtr0332420; dbxref=FlyBase:FBpp0304693,FlyBase_Annotation_IDs:CG13221-PB; MD5=4f4556dd59a240a6e0199b7136c95efb; length=178; release=r5.46; species=Dmel; [fly-062812-sfps-sandra-contam.fasta]
  • type=protein; loc=2R:11279878..11280414; ID=FBpp0087216; name=Vhl-PA; parent=FBgn0041174,FBtr0088115; dbxref=FlyBase:FBpp0087216,FlyBase_Annotation_IDs:CG13221-PA,GB_protein:AAF58684.1,REFSEQ:NP_524986,GB_protein:AAF58684,FlyMine:FBpp0087216,modMine:FBpp0087216; MD5=4f4556dd59a240a6e0199b7136c95efb; length=178; release=r6.02; species=Dmel; [fly-2014-05-contam.fasta]
  • type=protein; loc=2R:11279878..11280414; ID=FBpp0304693; name=Vhl-PB; parent=FBgn0041174,FBtr0332420; dbxref=FlyBase:FBpp0304693,FlyBase_Annotation_IDs:CG13221-PB,REFSEQ:NP_001260885,GB_protein:AGB93418; MD5=4f4556dd59a240a6e0199b7136c95efb; length=178; release=r6.02; species=Dmel; [fly-2014-05-contam.fasta]
  • type=protein; loc=2R:11279878..11280414; ID=FBpp0087216; name=Vhl-PA; parent=FBgn0041174,FBtr0088115; dbxref=FlyBase:FBpp0087216,FlyBase_Annotation_IDs:CG13221-PA,GB_protein:AAF58684.1,REFSEQ:NP_524986,GB_protein:AAF58684,FlyMine:FBpp0087216,modMine:FBpp0087216; MD5=4f4556dd59a240a6e0199b7136c95efb; length=178; release=r6.07; species=Dmel; [fly-08202015-contam.fasta]
  • type=protein; loc=2R:11279878..11280414; ID=FBpp0304693; name=Vhl-PB; parent=FBgn0041174,FBtr0332420; dbxref=FlyBase:FBpp0304693,FlyBase_Annotation_IDs:CG13221-PB,REFSEQ:NP_001260885,GB_protein:AGB93418; MD5=4f4556dd59a240a6e0199b7136c95efb; length=178; release=r6.07; species=Dmel; [fly-08202015-contam.fasta]
  • Isoform of Q9V3C1, von Hippel-Lindau, isoform B OS=Drosophila melanogaster GN=Vhl PE=1 SV=1 [DROME.fasta.20160308]
  • FBpp0087216 type=protein; loc=2R:11279878..11280414; ID=FBpp0087216; name=Vhl-PA; parent=FBgn0041174,FBtr0088115; dbxref=FlyBase:FBpp0087216,FlyBase_Annotation_IDs:CG13221-PA,GB_protein:AAF58684.1,REFSEQ:NP_524986,GB_protein:AAF58684,FlyMine:FBpp0087216,modMine:FBpp0087216; MD5=4f4556dd59a240a6e0199b7136c95efb; length=178; release=r6.09; species=Dmel; [dmel-all-translation-r6.09.fasta]
  • FBpp0304693 type=protein; loc=2R:11279878..11280414; ID=FBpp0304693; name=Vhl-PB; parent=FBgn0041174,FBtr0332420; dbxref=FlyBase:FBpp0304693,FlyBase_Annotation_IDs:CG13221-PB,REFSEQ:NP_001260885,GB_protein:AGB93418; MD5=4f4556dd59a240a6e0199b7136c95efb; length=178; release=r6.09; species=Dmel; [dmel-all-translation-r6.09.fasta]
  • [fly-122215-dmel-6-09-contam.fasta]
  • type=protein; loc=2R:11279878..11280414; ID=FBpp0087216; name=Vhl-PA; parent=FBgn0041174,FBtr0088115; dbxref=FlyBase:FBpp0087216,FlyBase_Annotation_IDs:CG13221-PA,GB_protein:AAF58684.1,REFSEQ:NP_524986,GB_protein:AAF58684,UniProt/Swiss-Prot:Q9V3C1,FlyMine:FBpp0087216,modMine:FBpp0087216; MD5=4f4556dd59a240a6e0199b7136c95efb; length=178; release=r6.14; species=Dmel; [fly-dmel-jan2017-sandracontam.fasta]
  • type=protein; loc=2R:11279878..11280414; ID=FBpp0304693; name=Vhl-PB; parent=FBgn0041174,FBtr0332420; dbxref=FlyBase:FBpp0304693,FlyBase_Annotation_IDs:CG13221-PB,REFSEQ:NP_001260885,GB_protein:AGB93418,UniProt/Swiss-Prot:Q9V3C1; MD5=4f4556dd59a240a6e0199b7136c95efb; length=178; release=r6.14; species=Dmel; [fly-dmel-jan2017-sandracontam.fasta]
    • Organism: Drosophila melanogaster
    Length: 178 amino acids

    Gene Ontology:
    Cellular Component: nucleus [IEA]
    VCB complex [IDA]
    Biological Process: cytoskeleton organization [IDA]
    open tracheal system development [IMP]
    protein ubiquitination [IDA]
    Molecular Function: ubiquitin-protein ligase activity [IDA]
    protein binding [IPI]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MALQIAQNNR DGQQLVGADQ GKVEVYVLFA NTTYRTLDLY WVCERERENM YLTLKPFEEV  60
   61 RVNTFTTHSW LFRDYYTGER MHVRSQRIFQ PIRVRVPKSQ QSPDQLVDVR SEVLIHFPMR 120
  121 SLRENCLWLV ARWLIRTSNA PRRIIHGYHI PSTLKQQLLS LLTCIESYSR VAGTRRRR

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..178] PSI-BLAST 43.09691 VHL

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • ubiquitin-protein ligase activity
    		•  8.01440994441489 bayes_pls_golite062009
  • small conjugating protein ligase activity
    		•  7.70942209868927 bayes_pls_golite062009
  • acid-amino acid ligase activity
    		•  6.77439707091624 bayes_pls_golite062009
  • ligase activity, forming carbon-nitrogen bonds
    		•  5.6984967446785 bayes_pls_golite062009
  • ligase activity
    		•  2.26622701577586 bayes_pls_golite062009
  • binding
    		•  1.62518429477421 bayes_pls_golite062009
  • protein binding
    		•  1.15073144761547 bayes_pls_golite062009
  • catalytic activity
    		•  0.334765053110546 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.98

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle