YRC Public Data Repository - Protein Structure Prediction

Protein:	Vhl-PA, FBpp0304693
Organism:	Drosophila melanogaster
Length:	178 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for Vhl-PA, FBpp0304693.

Description	E-value	Query Range	Subject Range
gi\|77454930 - gi\|77454930\|gb\|ABA86274.1\| CG13221 [Drosophila melanogaster]	244.0	[0..8]	[172..1]
gi\|77454934 - gi\|77454934\|gb\|ABA86276.1\| CG13221 [Drosophila simulans]	241.0	[0..8]	[172..1]
gi\|77454938, gi\|... - gi\|77454938\|gb\|ABA86278.1\| CG13221 [Drosophila yakuba], gi\|77454936\|gb\|ABA86277.1\| CG13221 [Drosophi...	241.0	[0..8]	[172..1]
gi\|77454940 - gi\|77454940\|gb\|ABA86279.1\| CG13221 [Drosophila erecta]	219.0	[0..8]	[172..1]
AGAP002496-PA - Von Hippel-Lindau disease tumor suppressor\|protein_coding\|2R:22013156:22013617:1\|gene:AGAP002496 gi\|58383182, gi\|... - gi\|58383182\|ref\|XP_312444.2\| ENSANGP00000022184 [Anopheles gambiae str. PEST], gi\|55242275\|gb\|EAA079...	179.0	[0..18]	[158..9]
VHL_CANLF - Von Hippel-Lindau disease tumor suppressor OS=Canis lupus familiaris GN=VHL PE=2 SV=1	179.0	[0..25]	[158..72]
VHL - von Hippel-Lindau tumor suppressor	179.0	[0..18]	[158..65]
gi\|197102444 - gi\|197102444\|ref\|NP_001126390.1\| von Hippel-Lindau tumor suppressor [Pongo abelii] gi\|55731296 - gi\|55731296\|emb\|CAH92362.1\| hypothetical protein [Pongo abelii]	179.0	[0..18]	[158..65]
gi\|54636429, gi\|... - gi\|54636429\|gb\|EAL25832.1\| GA12133-PA [Drosophila pseudoobscura], gi\|125809834\|ref\|XP_001361254.1\| G...	178.0	[0..1]	[169..1]

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Predicted Domain #1

Region A:
Residues: [1-178]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MALQIAQNNR DGQQLVGADQ GKVEVYVLFA NTTYRTLDLY WVCERERENM YLTLKPFEEV  60
   61 RVNTFTTHSW LFRDYYTGER MHVRSQRIFQ PIRVRVPKSQ QSPDQLVDVR SEVLIHFPMR 120
  121 SLRENCLWLV ARWLIRTSNA PRRIIHGYHI PSTLKQQLLS LLTCIESYSR VAGTRRRR

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	43.09691
Match:	1lqbC
Description:	VHL
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
ubiquitin-protein ligase activity	8.01440994441489	bayes_pls_golite062009
small conjugating protein ligase activity	7.70942209868927	bayes_pls_golite062009
acid-amino acid ligase activity	6.77439707091624	bayes_pls_golite062009
ligase activity, forming carbon-nitrogen bonds	5.6984967446785	bayes_pls_golite062009
ligase activity	2.26622701577586	bayes_pls_golite062009
binding	1.62518429477421	bayes_pls_golite062009
protein binding	1.15073144761547	bayes_pls_golite062009
catalytic activity	0.334765053110546	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: