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Protein Overview: cbx-PA

General Information:
Name(s) found: cbx-PA / FBpp0087537 [FlyBase]
Description(s) found:
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  • gi|25012278|gb|AAN71252.1| LD32963p [Drosophila melanogaster] [NCBI NR]
  • gi|24652233|ref|NP_724848.1| crossbronx, isoform A [Drosophila melanogaster] [NCBI NR]
  • gi|10727674|gb|AAG22290.1| crossbronx, isoform A [Drosophila melanogaster] [NCBI NR]
  • The gene crossbronx is referred to in FlyBase by the symbol Dmel\cbx (CG10536, FBgn0011241). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 2R:5752013..5762577. It has the cytological map location 46B4-46C1. An electronic pipeline based on InterPro domains suggests that it has the molecular function</span>: small conjugating protein ligase activity. There is experimental evidence that it is involved in the biological process</span>: spermatid development; sperm individualization. 14 alleles are reported. The phenotypes of these alleles are annotated with: spermatid; primary spermatocyte cyst; crystal cell; spermatozoon. It has 2 annotated transcripts and 2 annotated polypeptides. [FlyBase]
  • >CG10536-PA translation from_gene[CG10536 cbx FBgn0011241] seq_release:3 mol_weight=24572 cds_boundaries:(2R:4,925,226..4,925,983[-]) aa_length:214 transcript_info:[CG10536-RA seq_release:3] gene_info:[gene symbol:cbx FBgn0011241 gene_boundaries:(2R:4, [hmr_yeast5_DM3-1_pombe.fasta]
  • (Q9I7E8) CG10536 protein (EC 6.3.2.19) (Ubiquitin-conjugating enzyme E2) (Ubiquitin-protein ligase) (Ubiquitin carrier protein) (LD32963p) [DrosMelano7227.FASTAC.txt]
  • (AE003831) CG10536 gene product [alt 1] [Drosophila melanogaster] [yeastflysequest.fasta]
  • CG10536-PA, isoform A [Drosophila melanogaster]gi|24652233|ref|NP_724848.1| CG10536-PA [Drosophila melanogaster]gi|25012278|gb|AAN71252.1| LD32963p [Drosophila melanogaster] [nrdb_11152004_Chlamydomonas]
  • type=protein; loc=2R:complement(5752095..5752574,5752629..5752732,5752795..5752855); ID=FBpp0087537; name=cbx-PA; parent=FBgn0011241,FBtr0088452; dbxref=GB_protein:AAG22290.1,FlyBase:FBpp0087537,FlyBase_Annotation_IDs:CG10536-PA,REFSEQ:NP_724848,GB_protei [fly-100309-contam.fasta]
  • LD32963p [Drosophila melanogaster] [nr-271106-contam.fasta]
  • CG10536-PA, isoform A [Drosophila melanogaster] [nr-271106-contam.fasta]
  • crossbronx CG10536-PA, isoform A [Drosophila melanogaster] [nr-271106-contam.fasta]
  • type=protein; loc=2R:complement(5752095..5752574,5752629..5752732,5752795..5752855); ID=FBpp0087537; name=cbx-PA; parent=FBgn0011241,FBtr0088452; dbxref=GB_protein:AAG22290.1,FlyBase:FBpp0087537,FlyBase_Annotation_IDs:CG10536-PA,REFSEQ:NP_724848,GB_protein:AAG22290; MD5=97aeef907709d413d006b31956a99999; length=214; release=r5.16; species=Dmel; [fly-contam-His-TEV-Tub4complex.fasta]
  • type=protein; loc=2R:complement(5752095..5752574,5752629..5752732,5752795..5752855); ID=FBpp0087537; name=cbx-PA; parent=FBgn0011241,FBtr0088452; dbxref=GB_protein:AAG22290.1,FlyBase:FBpp0087537,FlyBase_Annotation_IDs:CG10536-PA,REFSEQ:NP_724848,GB_protein:AAG22290; MD5=97aeef907709d413d006b31956a99999; length=214; release=r5.21; species=Dmel; [Other_drosophila_na_09-09-2009_reversed.fasta]
  • Isoform A of Protein crossbronx OS=Drosophila melanogaster GN=cbx [UniProt_drosophila_07-01-2011_reversed.fasta]
  • type=protein; loc=2R:complement(5752095..5752574,5752629..5752732,5752795..5752855); ID=FBpp0087537; name=cbx-PA; parent=FBgn0011241,FBtr0088452; dbxref=GB_protein:AAG22290.1,FlyBase:FBpp0087537,FlyBase_Annotation_IDs:CG10536-PA,REFSEQ:NP_724848,GB_protein:AAG22290,FlyMine:FBpp0087537,modMine:FBpp0087537; MD5=97aeef907709d413d006b31956a99999; length=214; release=r5.46; species=Dmel; [fly-062812-sfps-sandra-contam.fasta]
  • type=protein; loc=2R:complement(join(9865290..9865350,9865124..9865227,9864590..9865069)); ID=FBpp0087537; name=cbx-PA; parent=FBgn0011241,FBtr0088452; dbxref=GB_protein:AAG22290.1,FlyBase:FBpp0087537,FlyBase_Annotation_IDs:CG10536-PA,REFSEQ:NP_724848,GB_protein:AAG22290,FlyMine:FBpp0087537,modMine:FBpp0087537; MD5=97aeef907709d413d006b31956a99999; length=214; release=r6.02; species=Dmel; [fly-2014-05-contam.fasta]
  • type=protein; loc=2R:complement(join(9865290..9865350,9865124..9865227,9864590..9865069)); ID=FBpp0087537; name=cbx-PA; parent=FBgn0011241,FBtr0088452; dbxref=GB_protein:AAG22290.1,FlyBase:FBpp0087537,FlyBase_Annotation_IDs:CG10536-PA,REFSEQ:NP_724848,GB_protein:AAG22290,FlyMine:FBpp0087537,modMine:FBpp0087537; MD5=97aeef907709d413d006b31956a99999; length=214; release=r6.07; species=Dmel; [fly-08202015-contam.fasta]
  • Isoform of Q7K4V4, Isoform A of Protein crossbronx OS=Drosophila melanogaster GN=cbx [DROME.fasta.20160308]
  • FBpp0087537 type=protein; loc=2R:complement(join(9865290..9865350,9865124..9865227,9864590..9865069)); ID=FBpp0087537; name=cbx-PA; parent=FBgn0011241,FBtr0088452; dbxref=GB_protein:AAG22290.1,FlyBase:FBpp0087537,FlyBase_Annotation_IDs:CG10536-PA,REFSEQ:NP_724848,GB_protein:AAG22290,FlyMine:FBpp0087537,modMine:FBpp0087537; MD5=97aeef907709d413d006b31956a99999; length=214; release=r6.09; species=Dmel; [dmel-all-translation-r6.09.fasta]
  • [fly-122215-dmel-6-09-contam.fasta]
  • type=protein; loc=2R:complement(join(9865290..9865350,9865124..9865227,9864590..9865069)); ID=FBpp0087537; name=cbx-PA; parent=FBgn0011241,FBtr0088452; dbxref=GB_protein:AAG22290.1,FlyBase:FBpp0087537,FlyBase_Annotation_IDs:CG10536-PA,REFSEQ:NP_724848,GB_protein:AAG22290,FlyMine:FBpp0087537,modMine:FBpp0087537; MD5=97aeef907709d413d006b31956a99999; length=214; release=r6.14; species=Dmel; [fly-dmel-jan2017-sandracontam.fasta]
    • Organism: Drosophila melanogaster
    Length: 214 amino acids

    Gene Ontology:
    Cellular Component: NONE FOUND
    Biological Process: NONE FOUND
    Molecular Function: NONE FOUND


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MIESEKLSGI YVIPSYANSL QWFGVFFGRQ GLYAESVFRF TILLPDRFPD DKSLPSIIFQ  60
   61 QDVIHPHVCP YTHSLDVSHA FPEWRCGEDH LWQLLKYLQV IFSDPLDSIR GIEVDKLKNS 120
  121 EAAELLMNNK EEYVARVQEN IKESKEHIFD TPPTEDPHYI VFEKFQQDVH GPVLERIKAG 180
  181 RSKLTEPSAQ QANGGHATGL SWVKEGEFKP LSIE

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..214] PSI-BLAST 34.522879 The Structure of a Class II ubiquitin-conjugating enzyme, Ubc1.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • ligase activity
    		•  0.518980612933125 bayes_pls_golite062009
  • ligase activity, forming carbon-nitrogen bonds
    		•  0.458241996059049 bayes_pls_golite062009
  • acid-amino acid ligase activity
    		•  0.410220984601774 bayes_pls_golite062009
  • small conjugating protein ligase activity
    		•  0.348950860132607 bayes_pls_golite062009
  • ubiquitin-protein ligase activity
    		•  0.0637241173104256 bayes_pls_golite062009
  • protein binding
    		•  0.030781579956521 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.80

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle