YRC Public Data Repository - Protein Structure Prediction

Protein:	cbx-PA
Organism:	Drosophila melanogaster
Length:	214 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for cbx-PA.

Description	E-value	Query Range	Subject Range
gi\|220953710, gi... - gi\|220960022\|gb\|ACL92547.1\| cbx-PA [synthetic construct], gi\|220953710\|gb\|ACL89398.1\| cbx-PA [synthe... cbx-PB - The gene crossbronx is referred to in FlyBase by the symbol Dmel\cbx (CG10536, FBgn0011241). It is a...	197.0	[0..1]	[214..31]
AKTIP_DANRE - AKT-interacting protein OS=Danio rerio GN=aktip PE=2 SV=1	189.0	[0..1]	[214..86]
gi\|55249837 - gb\|AAH85983.1\| Unknown (protein for MGC:97982) [Xenopus laevis] AKTIP_MOUSE - AKT-interacting protein OS=Mus musculus GN=Aktip PE=1 SV=1	188.0	[0..1]	[214..85]
AKTIP_RAT - AKT-interacting protein OS=Rattus norvegicus GN=Aktip PE=1 SV=1	188.0	[0..1]	[214..85]
gi\|73949850 - gi\|73949850\|ref\|XP_535302.2\| PREDICTED: similar to fused toes homolog isoform 1 [Canis familiaris]	187.0	[0..1]	[214..79]
FTS1_PONPY - Fused toes protein homolog - Pongo pygmaeus (Orangutan) AKTIP_PONAB - AKT-interacting protein OS=Pongo abelii GN=AKTIP PE=2 SV=1	187.0	[0..1]	[214..85]
gi\|61857114 - gi\|61857114\|ref\|XP_594197.1\| PREDICTED: fused toes homolog isoform 1 [Bos taurus]	186.0	[0..1]	[214..85]
gi\|63102175 - gi\|63102175\|gb\|AAH95401.1\| AKT interacting protein [Homo sapiens]	186.0	[0..1]	[214..85]
gi\|114662508, gi... - gi\|114662512\|ref\|XP_001166637.1\| PREDICTED: fused toes homolog isoform 7 [Pan troglodytes], gi\|11466... gi\|208965808 - gi\|208965808\|dbj\|BAG72918.1\| AKT interacting protein [synthetic construct] gi\|119603212, gi... - gi\|62897045\|dbj\|BAD96463.1\| fused toes homolog [Homo sapiens], gi\|119603213\|gb\|EAW82807.1\| fused toe...	186.0	[0..1]	[214..85]

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Predicted Domain #1

Region A:
Residues: [1-214]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MIESEKLSGI YVIPSYANSL QWFGVFFGRQ GLYAESVFRF TILLPDRFPD DKSLPSIIFQ  60
   61 QDVIHPHVCP YTHSLDVSHA FPEWRCGEDH LWQLLKYLQV IFSDPLDSIR GIEVDKLKNS 120
  121 EAAELLMNNK EEYVARVQEN IKESKEHIFD TPPTEDPHYI VFEKFQQDVH GPVLERIKAG 180
  181 RSKLTEPSAQ QANGGHATGL SWVKEGEFKP LSIE

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	34.522879
Match:	1tteA
Description:	The Structure of a Class II ubiquitin-conjugating enzyme, Ubc1.
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
ligase activity	0.518980612933125	bayes_pls_golite062009
ligase activity, forming carbon-nitrogen bonds	0.458241996059049	bayes_pls_golite062009
acid-amino acid ligase activity	0.410220984601774	bayes_pls_golite062009
small conjugating protein ligase activity	0.348950860132607	bayes_pls_golite062009
ubiquitin-protein ligase activity	0.0637241173104256	bayes_pls_golite062009
protein binding	0.030781579956521	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: