Protein Overview: Rya-r44F-PA

General Information:
Name(s) found:	Rya-r44F-PA / FBpp0087721 [FlyBase]
Description(s) found: SHOW ONLY BEST	gi\|33112444\|sp\|Q24498.3\|RY44_DROME RecName: Full=Ryanodine receptor 44F [NCBI NR] gi\|21645558\|gb\|AAF59036.2\| ryanodine receptor 44F, isoform A [Drosophila melanogaster] [NCBI NR] gi\|17352465\|ref\|NP_476991.1\| ryanodine receptor 44F, isoform A [Drosophila melanogaster] [NCBI NR] Ryanodine receptor OS=Drosophila melanogaster GN=RyR PE=1 SV=3 [Swiss-Prot] Ryanodine receptor 44F OS=Drosophila melanogaster GN=Rya-r44F PE=1 SV=3 [Swiss-Prot] The gene Ryanodine receptor 44F is referred to in FlyBase by the symbol Dmel\Rya-r44F (CG10844, FBgn0011286). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 2R:4747896..4775602. It has the cytological map location 44F1-44F2. Based on sequence similarity, it is predicted to have molecular function</span>: ryanodine-sensitive calcium-release channel activity. There is experimental evidence that it is involved in the biological process</span>: muscle contraction. 9 alleles are reported. The phenotypes of these alleles are annotated with: larva; larval head; embryonic/larval dorsal vessel; embryonic muscle system; embryonic/larval visceral muscle; embryonic/larval muscle system. It has 4 annotated transcripts and 4 annotated polypeptides. [FlyBase] >CG10844-PA translation from_gene[CG10844 Rya-r44F FBgn0011286] seq_release:3 mol_weight=581019 cds_boundaries:(2R:3,923,704..3,948,559[+]) aa_length:5127 transcript_info:[CG10844-RA seq_release:3] gene_info:[gene symbol:Rya-r44F FBgn0011286 gene_bound [hmr_yeast5_DM3-1_pombe.fasta] (Q24498) Ryanodine receptor 44F [DrosMelano7227.FASTAC.txt] CG10844-PA, isoform A [Drosophila melanogaster]gi\|17352465\|ref\|NP_476991.1\| CG10844-PA [Drosophila melanogaster]gi\|33112444\|sp\|Q24498\|RY44_DROME Ryanodine receptor 44F [nrdb_11152004_Chlamydomonas] type=protein; loc=2R:join(4750462..4750515,4753361..4753564,4754509..4754586,4754650..4755038,4755103..4755627,4755687..4755811,4755871..4757293,4757349..4757952,4758088..4758187,4759725..4759929,4759984..4760740,4760800..4761959,4762173..4762367,4762440. [fly-100309-contam.fasta] CG10844-PA, isoform A [Drosophila melanogaster] [nr-271106-contam.fasta] Ryanodine receptor 44F CG10844-PA, isoform A [Drosophila melanogaster] [nr-271106-contam.fasta] Ryanodine receptor 44F [nr-271106-contam.fasta] type=protein; loc=2R:join(4750462..4750515,4753361..4753564,4754509..4754586,4754650..4755038,4755103..4755627,4755687..4755811,4755871..4757293,4757349..4757952,4758088..4758187,4759725..4759929,4759984..4760740,4760800..4761959,4762173..4762367,4762440..4762555,4762862..4765134,4765643..4766122,4766723..4766860,4767014..4767300,4767362..4769459,4769809..4769921,4770559..4770904,4771127..4771427,4771720..4771830,4771888..4772307,4772376..4772577,4772641..4775320); ID=FBpp0087721; name=Rya-r44F-PA; parent=FBgn0011286,FBtr0088640; dbxref=FlyBase:FBpp0087721,FlyBase_Annotation_IDs:CG10844-PA,GB_protein:AAF59036.2,REFSEQ:NP_476991,GB_protein:AAF59036; MD5=f90935b4c470d1d12353ecdde59b660a; length=5127; release=r5.16; species=Dmel; [fly-contam-His-TEV-Tub4complex.fasta] type=protein; loc=2R:join(4750462..4750515,4753361..4753564,4754509..4754586,4754650..4755038,4755103..4755627,4755687..4755811,4755871..4757293,4757349..4757952,4758088..4758187,4759725..4759929,4759984..4760740,4760800..4761959,4762173..4762367,4762440..4762555,4762862..4765134,4765643..4766122,4766723..4766860,4767014..4767300,4767362..4769459,4769809..4769921,4770559..4770904,4771127..4771427,4771720..4771830,4771888..4772307,4772376..4772577,4772641..4775320); ID=FBpp0087721; name=Rya-r44F-PA; parent=FBgn0011286,FBtr0088640; dbxref=FlyBase:FBpp0087721,FlyBase_Annotation_IDs:CG10844-PA,GB_protein:AAF59036.2,REFSEQ:NP_476991,GB_protein:AAF59036; MD5=f90935b4c470d1d12353ecdde59b660a; length=5127; release=r5.21; species=Dmel; [Other_drosophila_na_09-09-2009_reversed.fasta] type=protein; loc=2R:join(4750462..4750515,4753361..4753564,4754509..4754586,4754650..4755038,4755103..4755627,4755687..4755811,4755871..4757293,4757349..4757952,4758088..4758187,4759725..4759929,4759984..4760740,4760800..4761959,4762173..4762367,4762440..4762555,4762862..4765134,4765643..4766122,4766723..4766860,4767014..4767300,4767362..4769459,4769809..4769921,4770559..4770904,4771127..4771427,4771720..4771830,4771888..4772307,4772376..4772577,4772641..4775320); ID=FBpp0087721; name=Rya-r44F-PA; parent=FBgn0011286,FBtr0088640; dbxref=FlyBase:FBpp0087721,FlyBase_Annotation_IDs:CG10844-PA,GB_protein:AAF59036.2,REFSEQ:NP_476991,GB_protein:AAF59036,FlyMine:FBpp0087721,modMine:FBpp0087721; MD5=f90935b4c470d1d12353ecdde59b660a; length=5127; release=r5.46; species=Dmel; [fly-062812-sfps-sandra-contam.fasta] type=protein; loc=2R:join(8862957..8863010,8865856..8866059,8867004..8867081,8867145..8867533,8867598..8868122,8868182..8868306,8868366..8869788,8869844..8870447,8870583..8870682,8872220..8872424,8872479..8873235,8873295..8874454,8874668..8874862,8874935..8875050,8875357..8877629,8878138..8878617,8879218..8879355,8879509..8879795,8879857..8881954,8882304..8882416,8883054..8883399,8883622..8883922,8884215..8884325,8884383..8884802,8884871..8885072,8885136..8887815); ID=FBpp0087721; name=RyR-PA; parent=FBgn0011286,FBtr0088640; dbxref=FlyBase:FBpp0087721,FlyBase_Annotation_IDs:CG10844-PA,GB_protein:AAF59036.2,REFSEQ:NP_476991,GB_protein:AAF59036,FlyMine:FBpp0087721,modMine:FBpp0087721; MD5=f90935b4c470d1d12353ecdde59b660a; length=5127; release=r6.02; species=Dmel; [fly-2014-05-contam.fasta] type=protein; loc=2R:join(8862957..8863010,8865856..8866059,8867004..8867081,8867145..8867533,8867598..8868122,8868182..8868306,8868366..8869788,8869844..8870447,8870583..8870682,8872220..8872424,8872479..8873235,8873295..8874454,8874668..8874862,8874935..8875050,8875357..8877629,8878138..8878617,8879218..8879355,8879509..8879795,8879857..8881954,8882304..8882416,8883054..8883399,8883622..8883922,8884215..8884325,8884383..8884802,8884871..8885072,8885136..8887815); ID=FBpp0087721; name=RyR-PA; parent=FBgn0011286,FBtr0088640; dbxref=FlyBase:FBpp0087721,FlyBase_Annotation_IDs:CG10844-PA,GB_protein:AAF59036.2,REFSEQ:NP_476991,GB_protein:AAF59036,FlyMine:FBpp0087721,modMine:FBpp0087721; MD5=f90935b4c470d1d12353ecdde59b660a; length=5127; release=r6.07; species=Dmel; [fly-08202015-contam.fasta] FBpp0087721 type=protein; loc=2R:join(8862957..8863010,8865856..8866059,8867004..8867081,8867145..8867533,8867598..8868122,8868182..8868306,8868366..8869788,8869844..8870447,8870583..8870682,8872220..8872424,8872479..8873235,8873295..8874454,8874668..8874862,8874935..8875050,8875357..8877629,8878138..8878617,8879218..8879355,8879509..8879795,8879857..8881954,8882304..8882416,8883054..8883399,8883622..8883922,8884215..8884325,8884383..8884802,8884871..8885072,8885136..8887815); ID=FBpp0087721; name=RyR-PA; parent=FBgn0011286,FBtr0088640; dbxref=FlyBase:FBpp0087721,FlyBase_Annotation_IDs:CG10844-PA,GB_protein:AAF59036.2,REFSEQ:NP_476991,GB_protein:AAF59036,FlyMine:FBpp0087721,modMine:FBpp0087721; MD5=f90935b4c470d1d12353ecdde59b660a; length=5127; release=r6.09; species=Dmel; [dmel-all-translation-r6.09.fasta] [fly-122215-dmel-6-09-contam.fasta] type=protein; loc=2R:join(8862957..8863010,8865856..8866059,8867004..8867081,8867145..8867533,8867598..8868122,8868182..8868306,8868366..8869788,8869844..8870447,8870583..8870682,8872220..8872424,8872479..8873235,8873295..8874454,8874668..8874862,8874935..8875050,8875357..8877629,8878138..8878617,8879218..8879355,8879509..8879795,8879857..8881954,8882304..8882416,8883054..8883399,8883622..8883922,8884215..8884325,8884383..8884802,8884871..8885072,8885136..8887815); ID=FBpp0087721; name=RyR-PA; parent=FBgn0011286,FBtr0088640; dbxref=FlyBase:FBpp0087721,FlyBase_Annotation_IDs:CG10844-PA,GB_protein:AAF59036.2,REFSEQ:NP_476991,GB_protein:AAF59036,UniProt/Swiss-Prot:Q24498,FlyMine:FBpp0087721,modMine:FBpp0087721; MD5=f90935b4c470d1d12353ecdde59b660a; length=5127; release=r6.14; species=Dmel; [fly-dmel-jan2017-sandracontam.fasta]
Organism:	Drosophila melanogaster
Length:	5127 amino acids
Gene Ontology:
Cellular Component:	endoplasmic reticulum membrane [NAS] integral to membrane [IEA][NAS]
Biological Process:	transmembrane transport [IEA] muscle contraction [IMP] calcium ion transport [IEA][TAS] cellular calcium ion homeostasis [IEA]
Molecular Function:	ryanodine-sensitive calcium-release channel activity [ISS][NAS][TAS] calcium ion binding [IEA]

Sequence:

Sequence:
[PDR BLAST]
[ProtParam]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MAEAEGGSEQ DDVSFLRTED MVTLSCTATG ERVCLAAEGF GNRHCFLENI ADKNVPPDLS  60
   61 QCVFVIEQAL SVRALQELVT AAGSETGKGT GSGHRTLLYG NAILLRHHNS DMYLACLSTS 120
  121 SSNDKLSFDV GLQEHSQGEA CWWTVHPASK QRSEGEKVRV GDDLILVSVA TERYLHTTKE 180
  181 NEQSIVNASF HVTHWSVQPY GTGISRMKYV GYVFGGDVLR FFHGGDECLT IPSTWGREAG 240
  241 QNIVIYEGGV VMAQARSLWR LELARTKWTG GFINWYHPMR IRHITTGRYL GVNDSNELIL 300
  301 VKKEEASIAT TTFCLRQEKD DEKKVLEDKD LEVIGSPIIK YGDTTVIVQH CETSLWLSYK 360
  361 SYETKKKGVG KVEEKQAILH EEGKMDDCLD FSRSQEEESK TARVIRKCSS LFTQFITALE 420
  421 TLQSNRRHSI FFQKVNLNEM VMCLEDLINY FSQPEDDMEH EEKQNRFRAL RNRQDLFQEE 480
  481 GVLNLILEAI DKINIITSQG FLASFLAGDE TGQSWDLIST YLYQLLAAII KGNHTNCAQF 540
  541 ANSNRLNWLF SRLGSQASSE GSGMLDVLHC VLIDSPEALN MMRDEHIKVI ISLLEKHGRD 600
  601 PKVLDVLCSL CVGNGVAVRS SQNNICDFLL PGKNLLLQTL LVDHVASIRP NIFVGRVDGS 660
  661 SMYQKWYFEV TMDHIEQTTH MMPHLRIGWA NTSGYVPYPG GGKKWGGNGV GDDLYSFGFD 720
  721 GAFLWTGGRK TLVVDALPEE PFIRKGDVIG VAIDLSVPII TFTFNGVKVR GSFRDFNLDG 780
  781 MFFPVMSCSS KLSCRFLFGG DHGRLKFAPP MGFSALVQCL MPQQILSLDP CFYFGNLAKN 840
  841 VLAGPWLIED DTAFVPKPVD TTGVTLPSSV DQIKEKLAEN IHEMWALNKI EAGWSWGEHR 900
  901 DDYHRIHPCL THFEKLPAAE KRYDNQLAVQ TLKTIISLGY YITMDKPPAR IRPVRLPNEI 960
  961 FMQGNGYKPA PLDLSAVTLT PKLEELVDQL AENTHNLWAR ERIQQGWTYG LNEDSENHRS1020
 1021 PHLVPYAKVD EAIKKANRDT ASETVRTLLV YGYVLDPPTG EGTEALLAEA QRLKFAGFRT1080
 1081 YRVERNYAVT SGKWYFEFEV LTSGPMRVGW ARADCYPGAM LGSEDTSWAF DGHNVTKMHA1140
 1141 GSIEHFGVRY EAGDVIGCFI DVKEQTISFS LNGELLMDAL GGETTFADVT AEGVGFVPAC1200
 1201 TLGVGQKARL IYGQDVDSLK FFTTCGLQEG YEPFCVNMRR PVTHWYTKDQ PIFENTEEMP1260
 1261 DCRIDVTRIP GGADTPPHLK ISHNTFETME KANWEFLRLS LPVTCMGEFI SEQEKARRWD1320
 1321 EIKNRQYRLM REAEIAAQMQ VQTQAAHMDH MLKGGFNMND IKGLTRNFDE HADAEADHMM1380
 1381 RGPNRPPRKG SLTRNITFET DMSAALDEMQ RSTSVLDMNG LGEEMDDKKK RGRSPFKFFS1440
 1441 KKSRDQSREK MGARTLDTSL ERRNTVAHGR NVVNQQMTTR APTLRLNNAE IPPSPVPQGP1500
 1501 KQLSGSNLGQ QPVETSGDEM FDAECLKLIN EYFYGVRIFP GQDPTHVYVG WVTTQYHLHS1560
 1561 REFNKNKVRR GSVYIEDDYE MAIERIDRQS CYVVRADELF NEVTQDASGK GASQGMFVGC1620
 1621 FVDTATGIIR FTCEGKDTSH RWMMEPDTKL FPAIFVEATS KEILQIELGR TPTTLPLSAA1680
 1681 VLPTSDKHIN PQSPPRLKVQ CLRPHQWARV PNTALQVHAL KLSDVRGWSM LCEDPVSMLA1740
 1741 LHIPEEDRCI DILELIEMDK LLSFHAHSLT LYAALCYQSN YRAAHALCQH VDQKQLLYAI1800
 1801 RSEYMSGPLR QGFYDLLIAL HLESHATTME VCKNEYITPL GAELKELYSD EEMQHSLRSL1860
 1861 VTESVRPQLR MTEITPPVIA TSSMPSVSSE PIPDIDQLYS PKFPLEVVRQ FVMEALKDAV1920
 1921 EINQVHNRDP IGWTNENLFL PLIKLTDRLL LVGVLTDEDV QRLLVMIDPE TWDQAFEREG1980
 1981 KDEHRKGLLT MKMAEGAKLQ MCYLLHHLYD TQLRHRVESI IAFSHDFVGD LQTDQLRRYI2040
 2041 EIKQSDLPSA VAAKKTKEFR CPPREQMNQI LCFKNLEPDD QDNCTCGLEL RGRLGDFHDS2100
 2101 LMQKVSLNAL QEPDGVEGTA IEEVKTGPIT KIYNFINTVK ELEEGPKEVE EPEKKTPEEV2160
 2161 FRKVLIKTIV SWAEESQIEN PKLVREMFSL LLRQYDTVGE LVRALEKTYV INTRARDDVA2220
 2221 EMWVGLSQIR ALLPVQMSQE EEELMRKRLW KLVNNATFFQ HPDLIRILRV HENVMAVMMN2280
 2281 TLGRRAQAQS DAPTQSEVAE GAPSKEKDTS HEMVVACCRF LCYFCRTGRQ NQKAMFDHFD2340
 2341 FLLDNANILL ARPSLRGSTP LDVAYSSLME NTELALALRE HYLEKIAVYL SRCGLQSNSE2400
 2401 LVEKGYPDLG WDPVEGERYL DFLRYCVWVN GESVEENANL VIRLLIRRPE CLGPALRGEG2460
 2461 EGLFRAIVEA NRMSERISDR CKMQDEAEGT IAGLNFTHPL PEGEEDEDYI DTGAAILNFY2520
 2521 CTLVDLLGRC APDASVIEQG KNESLRARAI LRSLVPLEDL QGVLSLKFTL SQTAPGEEKP2580
 2581 KSDMPSGLLP NNKQSIVLFL ERVYGIEAQD LFYRLLEDAF LPDLRTATIL DKSDGSESDM2640
 2641 ALAMNRYIGN SILPLLIKHS KFYNEAENYA SLLDATLHTV YRLSKNRMLT KGQREAVSDF2700
 2701 LVALTSQMQP AMLLKLLRKL TVDVSKLSEY TTVALRLLTL HFDRCAKYYG STQGQGSYGA2760
 2761 SSDEEKRLTM LLFSNIFDSL SNMDYDPELF GKALPCLIAI GCALPPDYSL SKNTDEDYYG2820
 2821 RQMGAPDQPQ YMPNPIDTNN VHLDNDLNSL VQKFSEHYHD AWASRRLEGG WTYGDIRSDN2880
 2881 DRKHPRLKPY NMLSEYERER YRDPVRECLK GLLAIGWTVE HSEVEVALNH RGSTRRQSKP2940
 2941 QINEFQNEGS PFNYNPHPVD MSNLTLSREM QNMAERLAEN SHDIWAKKKN EELNGCGGVI3000
 3001 HPQLVPYDLL TDKEKKKDRE RSQEFLKYMQ YQGYKLHKPS KGGAVEEGGA TQAAVELRFS3060
 3061 YSLLEKLIQY LDRATINMKL LKPSTTFSRR SSFKTATRDI KFFSKVVLPL MEKYFSTHRN3120
 3121 YFIAIATATN NIGAASLKEK EMVASIFCKL AALLRNRLSA FGPDVRITVR CLQVLVKGID3180
 3181 ARTLTKNCPE FIRTSMLTFF NQTSDDLGNT ILNLQDGKYS HLRGTHLKTS TSLGYVNQVV3240
 3241 LPVLTAMFDH LAACDYGSDL LLDEIQVASY KILAALYHLG TDGTLTHDRK YLKTEIERHR3300
 3301 PALGSCLGAY SSCFPVAFLE PHLNKHNQYS LLNRIADHSL EAQDIMVKME SCMPNLETIL3360
 3361 AEVDQFVESD KTYNDAPHII DVILPLLCAY LPFWWSQGPD NVSPTSGNHV TMVTADHMNP3420
 3421 LLRNVLKMIK KNIGNDNAPW MTRIAAYTQQ IIINTSEELL KDPFLPLAER VKKRTENMLH3480
 3481 KEDSMRGFIK SATDDTSQVE TQLQEDWNLL VRDIYSFYPL LIKYVDLQRN HWLKDNIPEA3540
 3541 EELYNHVAEI FNIWSKSQYF LKEEQNFISA NEIDNMALIM PTATRRSAIS EGAPAVGGKV3600
 3601 KKKKKNRDKK RDKDKEVQAS LMVACLKRLL PVGLNLFAGR EQELVQHCKD RYLKKMPEYD3660
 3661 VIEFARNQLT LPDKLDPSDE MSWQHYLYSK LGKTEEPVDE QALEKANVNS NEKGKDKTQE3720
 3721 TVDRIVAMAK VLFGLHMIDH PQQQSKNVYR SVVSIQRKRA VIACFRQTSL HSLPRHRACN3780
 3781 IFARSYYEQW LQEENVGQEV MVEDLTQTFE DSEKSKKEGE ETDSKPDPLT QLVTTFCRGA3840
 3841 MTERSGALQE DLLYMSYAQI AAKSTGKEEE EGGDEEGGEG GEEGEGTSIH EQEMEKQKLL3900
 3901 FHQARLSNRG VAEMVLLHIS ASKGIPSEMV MTTLNLGIAI LRGGNIDIQM GMLNHLKEKK3960
 3961 DVGFFTSIAG LMNSCSVLDL DAFERNTKAE GLGVGSEGAA GEKNMHDAEF TCALFRFIQL4020
 4021 TCEGHNLEWQ NYLRTQAGNT TTVNVVICTV DYLLRLQESI MDFYWHYSSK EIIDPAGKAN4080
 4081 FFKAIEVASQ VFNTLTEVIQ GPCTLNQQAL AHSRLWDAVG GFLFLFSHMQ DKLSKHSSQV4140
 4141 DLLKELLNLQ KDMITMMLSM LEGNVVNGTI GKQMVDTLVE SASNVELILK YFDMFLKLAD4200
 4201 LIESPSFHEV DMKNEGWVTP KDFREKMEQS KNYTPEEMDF LLACCERNHE GKIDYRAFVE4260
 4261 HFHEPSKEIG FNLAVLLTNL SEHMPNEPRL ARFLETAGSV LNYFEPFLGR IEILGSSKRI4320
 4321 ERVYFEIKDS NIEQWEKPQI RESKRAFFYS IVTEGGDKEK LEAFVNFCED AIFEMTHASG4380
 4381 LMATDDGGGN VKRDTAYSSY MSEEEEERAA RDPIRRTITA VKEGLKFGVH MLSPANIKHQ4440
 4441 IGVMQTKSIP ELIVGFFKII FYIFYYTGYA HFCVVRYIFG ILLNLMRGPA PEQEEEPVVE4500
 4501 EETFGRALPP LPLEEPPGTV QAFGLDINKE ENGMYKVVVH ESPANSSMEE GGESSPEDGA4560
 4561 AASGELVEGE PHQEPISIVD LLGGEAAKKA AQERQEAQKA QEAAMASIEA EAKKSSSAPQ4620
 4621 ETPAVHQIDF SQYTHRAVSF LARNFYNLKY VALVLAFSIN FMLLFYKVTS FTEEADSSAE4680
 4681 EELILGSGSG GGADITGSGF GGSGDGGSGD GEMEDEIPEL VHVDEDFFYM EHVLRIAACL4740
 4741 HSLVSLAMLI AYYHLKVPLA IFKREKEIAR RLEFEGLFIA EQPEDDDFKS HWDKLVISAK4800
 4801 SFPVNYWDKF VKKKVRQKYS ETYDFDSISN LLGMEKSTFA AQESEETGIF KYIMNIDWRY4860
 4861 QVWKAGVTFT DNAFLYSLWY FSFSVMGNFN NFFFAAHLLD VAVGFKTLRT ILQSVTHNGK4920
 4921 QLVLTVMLLT IIVYIYTVIA FNFFRKFYIQ EEDEEVDKKC HDMLTCFVFH LYKGVRAGGG4980
 4981 IGDEIGDPDG DDYEVYRIIF DITFFFFVII ILLAIIQGLI IDAFGELRDQ LESVKDNMES5040
 5041 NCFICGMGKD FFDIVPHGFD THVQKEHNLA NYMFFLMHLI NKPDTEYTGQ ETYVWNMYQQ5100
 5101 RSWDFFPVGD CFRKQYEDEL SGGGGGG

Protein Complex Data

No complex found for this protein.

Mass Spectrometry Data

No mass spectrometry results found for this protein.

Yeast Two-Hybrid Data

The following interactions contain this protein:

SHOWING SINGLE HITS. [ Hide Single Hits ]

[View our yeast two-hybrid interpretation guidelines.]

No yeast two-hybrid interactions found for this protein.

Protein Overview: Rya-r44F-PA

Protein Complex Data

Mass Spectrometry Data

Yeast Two-Hybrid Data

Microscopy / Localization Data

Protein Structure Data

Philius Transmembrane Prediction: