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Protein Overview: Tdc2-PA

General Information:
Name(s) found: Tdc2-PA / FBpp0085475 [FlyBase]
Description(s) found:
Found 19 descriptions.
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  • The gene Tyrosine decarboxylase 2 is referred to in FlyBase by the symbol Dmel\Tdc2 (CG30446, FBgn0050446). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 2R:2572477..2577467. It has the cytological map location 42C4. Based on sequence similarity, it is predicted to have molecular function</span>: tyrosine decarboxylase activity; aromatic-L-amino-acid decarboxylase activity. There is experimental evidence that it is involved in the biological process</span>: locomotory behavior; oviposition; behavioral response to cocaine. 4 alleles are reported. The phenotype of these alleles is annotated with: adult brain. It has one annotated transcript and one annotated polypeptide. [FlyBase]
    • Organism: Drosophila melanogaster
    Length: 637 amino acids

    Gene Ontology:
    Cellular Component: NONE FOUND
    Biological Process: locomotory behavior [IMP]
    behavioral response to cocaine [IMP]
    cellular amino acid and derivative metabolic process [IEA]
    oviposition [IMP]
    carboxylic acid metabolic process [IEA]
    Molecular Function: pyridoxal phosphate binding [IEA]
    tyrosine decarboxylase activity [ISS]
    aromatic-L-amino-acid decarboxylase activity [ISS]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MDSTEFRKRG MEMVEYICNY LETLNERRVT PSVEPGYLRH LLPPEAPQEP EDWDQIMRDV  60
   61 EDKIMPGVTH WQHPRFHAYF PAGNSFPSIL GDMLGDGIGC IGFSWAASPA CTELETIVLD 120
  121 WLGKAIGLPD HFLALKEGST GGGVIQTSAS ECVLVTMLAA RAQALKRLKA QHPFVEEGHL 180
  181 LSKLMAYCSK EAHSCVEKAA MICFVKLRIL EPDDDASLRG QTIYEAMEED ELQGLVPFFV 240
  241 STTLGTTGSC AFDNLPEIGK QLQRFPGVWL HVDAAYAGNS FICPELKPLL KGIEYADSFN 300
  301 TNPNKWLLTN FDCSTLWVRD RIRLTSALVV DPLYLKHGYS DAAIDYRHWG VPLSRRFRSL 360
  361 KLWFVLRSYG ISGLQHYIRH HIKLAKRFEE LVLKDKRFEI CNQVKLGLVC FRLKGSDKLN 420
  421 EKLLSIINES GKLHMVPASV GDRYIIRFCA VAQNATAEDI DYAWDIIVDF ANELLEKEQH 480
  481 DELSEIMNRK KQDTLAQKRS FFVRMVSDPK IYNPAINKAG TPKLSMELPS PVVSRGSAPI 540
  541 IRTQSSVDHN SWISWPLAFL FNSNNEEKGS NVSLRFRHLD TNVRPSSSRR NSGAGSSPSP 600
  601 ENELDYVNVQ QQQMEQRSPR RSPMAVRKAS STRDNLN

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..480] PSI-BLAST 115.0 DOPA decarboxylase
    2 View Details [481..547] PSI-BLAST 30.69897 Human mitochondrial serine hydroxymethyltransferase 2
    3 View Details [548..637] deduced N/A No confident structure predictions are available.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • 4-aminobutyrate transaminase activity
    		•  2.49533238079952 bayes_pls_golite062009
  • catalytic activity
    		•  2.29878871754893 bayes_pls_golite062009
  • transferase activity, transferring nitrogenous groups
    		•  1.28316822767388 bayes_pls_golite062009
  • transaminase activity
    		•  1.24990480711889 bayes_pls_golite062009
  • glutamate decarboxylase activity
    		•  1.23912528700231 bayes_pls_golite062009
  • 5-aminolevulinate synthase activity
    		•  1.01853440922526 bayes_pls_golite062009
  • transferase activity
    		•  0.737426388870721 bayes_pls_golite062009
  • succinate-semialdehyde dehydrogenase binding
    		•  0.408430609033885 bayes_pls_golite062009
  • glycine dehydrogenase (decarboxylating) activity
    		•  0.390162083170876 bayes_pls_golite062009
  • oxidoreductase activity, acting on the CH-NH2 group of donors, disulfide as acceptor
    		•  0.390162083170876 bayes_pls_golite062009
  • binding
    		•  0.252160165096264 bayes_pls_golite062009
  • N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
    		•  0.223759435414525 bayes_pls_golite062009
  • L-aspartate:2-oxoglutarate aminotransferase activity
    		•  0.130698724135981 bayes_pls_golite062009
  • carbon-carbon lyase activity
    		•  0.11598778799668 bayes_pls_golite062009
  • aromatic-L-amino-acid decarboxylase activity
    		•  0.10589462882093 bayes_pls_golite062009
    2 No functions predicted.
    3 No functions predicted.


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.93

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle