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View Structure Prediction Details

Protein: Tdc2-PA
Organism: Drosophila melanogaster
Length: 637 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for Tdc2-PA.

Description E-value Query
Range
Subject
Range
gi|54635312|gb|E... - GA15851-PA [Drosophila pseudoobscura], GA15851 [Drosophila pseudoobscura pseudoobscura]
gi|125806728, gi... - gi|54635312|gb|EAL24715.1| GA15851 [Drosophila pseudoobscura pseudoobscura], gi|125806728|ref|XP_001...
580.0 [0..1] [637..1]

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Predicted Domain #1
Region A:
Residues: [1-480]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MDSTEFRKRG MEMVEYICNY LETLNERRVT PSVEPGYLRH LLPPEAPQEP EDWDQIMRDV  60
   61 EDKIMPGVTH WQHPRFHAYF PAGNSFPSIL GDMLGDGIGC IGFSWAASPA CTELETIVLD 120
  121 WLGKAIGLPD HFLALKEGST GGGVIQTSAS ECVLVTMLAA RAQALKRLKA QHPFVEEGHL 180
  181 LSKLMAYCSK EAHSCVEKAA MICFVKLRIL EPDDDASLRG QTIYEAMEED ELQGLVPFFV 240
  241 STTLGTTGSC AFDNLPEIGK QLQRFPGVWL HVDAAYAGNS FICPELKPLL KGIEYADSFN 300
  301 TNPNKWLLTN FDCSTLWVRD RIRLTSALVV DPLYLKHGYS DAAIDYRHWG VPLSRRFRSL 360
  361 KLWFVLRSYG ISGLQHYIRH HIKLAKRFEE LVLKDKRFEI CNQVKLGLVC FRLKGSDKLN 420
  421 EKLLSIINES GKLHMVPASV GDRYIIRFCA VAQNATAEDI DYAWDIIVDF ANELLEKEQH 480
  481 

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 115.0
Match: 1js3A
Description: DOPA decarboxylase
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
4-aminobutyrate transaminase activity 2.49533238079952 bayes_pls_golite062009
catalytic activity 2.29878871754893 bayes_pls_golite062009
transferase activity, transferring nitrogenous groups 1.28316822767388 bayes_pls_golite062009
transaminase activity 1.24990480711889 bayes_pls_golite062009
glutamate decarboxylase activity 1.23912528700231 bayes_pls_golite062009
5-aminolevulinate synthase activity 1.01853440922526 bayes_pls_golite062009
transferase activity 0.737426388870721 bayes_pls_golite062009
succinate-semialdehyde dehydrogenase binding 0.408430609033885 bayes_pls_golite062009
glycine dehydrogenase (decarboxylating) activity 0.390162083170876 bayes_pls_golite062009
oxidoreductase activity, acting on the CH-NH2 group of donors, disulfide as acceptor 0.390162083170876 bayes_pls_golite062009
binding 0.252160165096264 bayes_pls_golite062009
N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity 0.223759435414525 bayes_pls_golite062009
L-aspartate:2-oxoglutarate aminotransferase activity 0.130698724135981 bayes_pls_golite062009
carbon-carbon lyase activity 0.11598778799668 bayes_pls_golite062009
aromatic-L-amino-acid decarboxylase activity 0.10589462882093 bayes_pls_golite062009

Predicted Domain #2
Region A:
Residues: [481-547]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 DELSEIMNRK KQDTLAQKRS FFVRMVSDPK IYNPAINKAG TPKLSMELPS PVVSRGSAPI  60
   61 IRTQSSV

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 30.69897
Match: 2a7vA
Description: Human mitochondrial serine hydroxymethyltransferase 2
Matching Structure (courtesy of the PDB):

Predicted Domain #3
Region A:
Residues: [548-637]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 DHNSWISWPL AFLFNSNNEE KGSNVSLRFR HLDTNVRPSS SRRNSGAGSS PSPENELDYV  60
   61 NVQQQQMEQR SPRRSPMAVR KASSTRDNLN 

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.


YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle