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Protein Overview: Fmo-2-PA

General Information:
Name(s) found: Fmo-2-PA / FBpp0085481 [FlyBase]
Description(s) found:
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  • gi|7302273|gb|AAF57364.1| Flavin-containing monooxygenase 2 [Drosophila melanogaster] [NCBI NR]
  • gi|19921694|ref|NP_610217.1| Flavin-containing monooxygenase 2 [Drosophila melanogaster] [NCBI NR]
  • gi|16182789|gb|AAL13578.1| GH12207p [Drosophila melanogaster] [NCBI NR]
  • The gene Flavin-containing monooxygenase 2 is referred to in FlyBase by the symbol Dmel\Fmo-2 (CG3174, FBgn0033079). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 2R:2529922..2532585. It has the cytological map location 42B2. There is experimental evidence that it has the molecular function</span>: monooxygenase activity. An electronic pipeline based on InterPro domains suggests that it is involved in the biological process</span>: oxidation reduction. 2 alleles are reported. No phenotypic data is available. It has one annotated transcript and one annotated polypeptide. [FlyBase]
  • >CG3174-PA translation from_gene[CG3174 Fmo-2 FBgn0033079] seq_release:3 mol_weight=49208 cds_boundaries:(2R:1,703,609..1,705,913[-]) aa_length:429 transcript_info:[CG3174-RA seq_release:3] gene_info:[gene symbol:Fmo-2 FBgn0033079 gene_boundaries:(2R:1 [hmr_yeast5_DM3-1_pombe.fasta]
  • (Q9V9C9) CG3174 protein (GH12207P) [DrosMelano7227.FASTAC.txt]
  • (AE003789) CG3174 gene product [Drosophila melanogaster] [yeastflysequest.fasta]
  • CG3174-PA [Drosophila melanogaster]gi|16182789|gb|AAL13578.1| GH12207p [Drosophila melanogaster]gi|19921694|ref|NP_610217.1| CG3174-PA [Drosophila melanogaster] [nrdb_11152004_Chlamydomonas]
  • type=protein; loc=2R:complement(2530209..2530388,2530508..2531046,2531717..2531888,2531999..2532188,2532247..2532409,2532471..2532516); ID=FBpp0085481; name=Fmo-2-PA; parent=FBgn0033079,FBtr0086148; dbxref=FlyBase:FBpp0085481,FlyBase_Annotation_IDs:CG3174 [fly-100309-contam.fasta]
  • CG3174-PA [Drosophila melanogaster] [nr-271106-contam.fasta]
  • Flavin-containing monooxygenase 2 CG3174-PA [Drosophila melanogaster] [nr-271106-contam.fasta]
  • GH12207p [Drosophila melanogaster] [nr-271106-contam.fasta]
  • type=protein; loc=2R:complement(2530209..2530388,2530508..2531046,2531717..2531888,2531999..2532188,2532247..2532409,2532471..2532516); ID=FBpp0085481; name=Fmo-2-PA; parent=FBgn0033079,FBtr0086148; dbxref=FlyBase:FBpp0085481,FlyBase_Annotation_IDs:CG3174-PA,GB_protein:AAF57364.1,REFSEQ:NP_610217,GB_protein:AAF57364; MD5=5fdb46f1d8f05c6c5263c30dbd03c370; length=429; release=r5.16; species=Dmel; [fly-contam-His-TEV-Tub4complex.fasta]
  • type=protein; loc=2R:complement(2530209..2530388,2530508..2531046,2531717..2531888,2531999..2532188,2532247..2532409,2532471..2532516); ID=FBpp0085481; name=Fmo-2-PA; parent=FBgn0033079,FBtr0086148; dbxref=FlyBase:FBpp0085481,FlyBase_Annotation_IDs:CG3174-PA,GB_protein:AAF57364.1,REFSEQ:NP_610217,GB_protein:AAF57364; MD5=5fdb46f1d8f05c6c5263c30dbd03c370; length=429; release=r5.21; species=Dmel; [Other_drosophila_na_09-09-2009_reversed.fasta]
  • Flavin-containing monooxygenase 2 OS=Drosophila melanogaster GN=Fmo-2 PE=1 SV=1 [UniProt_drosophila_07-01-2011_reversed.fasta]
  • type=protein; loc=2R:complement(2530209..2530388,2530508..2531046,2531717..2531888,2531999..2532188,2532247..2532409,2532471..2532516); ID=FBpp0085481; name=Fmo-2-PA; parent=FBgn0033079,FBtr0086148; dbxref=FlyBase:FBpp0085481,FlyBase_Annotation_IDs:CG3174-PA,GB_protein:AAF57364.1,REFSEQ:NP_610217,GB_protein:AAF57364,FlyMine:FBpp0085481,modMine:FBpp0085481; MD5=5fdb46f1d8f05c6c5263c30dbd03c370; length=429; release=r5.46; species=Dmel; [fly-062812-sfps-sandra-contam.fasta]
  • Flavin-containing monooxygenase 2 OS=Drosophila melanogaster GN=Fmo-2 PE=2 SV=1 [UniProt_D_Melanogaster_07132012_07-13-2012_reversed.fasta]
  • type=protein; loc=2R:complement(join(6644966..6645011,6644742..6644904,6644494..6644683,6644212..6644383,6643003..6643541,6642704..6642883)); ID=FBpp0085481; name=Fmo-2-PA; parent=FBgn0033079,FBtr0086148; dbxref=FlyBase:FBpp0085481,FlyBase_Annotation_IDs:CG3174-PA,GB_protein:AAF57364.1,REFSEQ:NP_610217,GB_protein:AAF57364,FlyMine:FBpp0085481,modMine:FBpp0085481; MD5=5fdb46f1d8f05c6c5263c30dbd03c370; length=429; release=r6.02; species=Dmel; [fly-2014-05-contam.fasta]
  • type=protein; loc=2R:complement(join(6644966..6645011,6644742..6644904,6644494..6644683,6644212..6644383,6643003..6643541,6642704..6642883)); ID=FBpp0085481; name=Fmo-2-PA; parent=FBgn0033079,FBtr0086148; dbxref=FlyBase:FBpp0085481,FlyBase_Annotation_IDs:CG3174-PA,GB_protein:AAF57364.1,REFSEQ:NP_610217,GB_protein:AAF57364,FlyMine:FBpp0085481,modMine:FBpp0085481; MD5=5fdb46f1d8f05c6c5263c30dbd03c370; length=429; release=r6.07; species=Dmel; [fly-08202015-contam.fasta]
  • Flavin-containing monooxygenase OS=Drosophila melanogaster GN=Fmo-2 PE=1 SV=1 [DROME.fasta.20160308]
  • FBpp0085481 type=protein; loc=2R:complement(join(6644966..6645011,6644742..6644904,6644494..6644683,6644212..6644383,6643003..6643541,6642704..6642883)); ID=FBpp0085481; name=Fmo-2-PA; parent=FBgn0033079,FBtr0086148; dbxref=FlyBase:FBpp0085481,FlyBase_Annotation_IDs:CG3174-PA,GB_protein:AAF57364.1,REFSEQ:NP_610217,GB_protein:AAF57364,FlyMine:FBpp0085481,modMine:FBpp0085481; MD5=5fdb46f1d8f05c6c5263c30dbd03c370; length=429; release=r6.09; species=Dmel; [dmel-all-translation-r6.09.fasta]
  • [fly-122215-dmel-6-09-contam.fasta]
  • type=protein; loc=2R:complement(join(6644966..6645011,6644742..6644904,6644494..6644683,6644212..6644383,6643003..6643541,6642704..6642883)); ID=FBpp0085481; name=Fmo-2-PA; parent=FBgn0033079,FBtr0086148; dbxref=FlyBase:FBpp0085481,FlyBase_Annotation_IDs:CG3174-PA,GB_protein:AAF57364.1,REFSEQ:NP_610217,GB_protein:AAF57364,UniProt/TrEMBL:Q7K3U4,FlyMine:FBpp0085481,modMine:FBpp0085481; MD5=5fdb46f1d8f05c6c5263c30dbd03c370; length=429; release=r6.14; species=Dmel; [fly-dmel-jan2017-sandracontam.fasta]
    • Organism: Drosophila melanogaster
    Length: 429 amino acids

    Gene Ontology:
    Cellular Component: mitochondrion [IDA]
    microsome [IDA]
    cytosol [IDA]
    Biological Process: oxidation reduction [IEA]
    Molecular Function: NADP or NADPH binding [IEA]
    FAD binding [IEA]
    monooxygenase activity [IDA]
    flavin-containing monooxygenase activity [ISS][NAS]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MIKTSVDKRR VCVIGAGTAG LCALKNSLEA GLDAVAYERG TEIGGTWIFS EEMPKDEYDE  60
   61 VHSSMYEGLR TNLPKEVMGY PDYSYPDDIT ESFITSNQVL EFLRSYAEHF KLKAHIKLQH 120
  121 EVIRVRPRLD DWEVYVWDHS TDTCDPVYYD FVYVCNGHYT EPDLPEVEGL DLFEGNKMHS 180
  181 HLYRKADKFK DARVLIIGAG PSGMDITNHV RLAAKQVFLS HHLSTTPNTA FMGNVTQKPD 240
  241 VKRFTKDGAV FTDGSTESFD HVMFCTGYKY TFPCLSTDVG VQVIDNFVQP LWKHCININH 300
  301 PTMAFVGLPF NVIPTHIFDM QVRFTLKFFT GQRKFPSREQ MIADLEQEIG ERWGCGVRNQ 360
  361 KKAHQMGERQ FVYYNELASI AGIENIKPVI HKLMKDCGKK YIFELDTYRS NKYTILDDEN 420
  421 FLKNGEAIV

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    SHOWING SINGLE HITS. [ Hide Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..336] PSI-BLAST 27.39794 Crystal structure of a protein with similarity to flavin-containing monooxygenases and to mammalian dimethylalanine monooxygenases
    2 View Details [337..429] deduced N/A No confident structure predictions are available.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • oxidoreductase activity
    		•  2.37832337019921 bayes_pls_golite062009
  • monooxygenase activity
    		•  1.9668697934131 bayes_pls_golite062009
  • catalytic activity
    		•  1.56773888754354 bayes_pls_golite062009
  • antioxidant activity
    		•  1.49429830917872 bayes_pls_golite062009
  • oxidoreductase activity, acting on sulfur group of donors
    		•  1.39990343076756 bayes_pls_golite062009
  • binding
    		•  0.439539948156364 bayes_pls_golite062009
  • oxidoreductase activity, acting on sulfur group of donors, NAD or NADP as acceptor
    		•  0.160937050611661 bayes_pls_golite062009
    2 No functions predicted.


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    [View Details]
    Source: Reynolds et al. 2008. Manuscript submitted Philius confidence legend
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