Protein Overview: rtGEF-PB, rtGEF-PA

General Information:
Name(s) found:	rtGEF-PB / FBpp0080889 [FlyBase] rtGEF-PA / FBpp0080888 [FlyBase]
Description(s) found: SHOW ONLY BEST	gi\|7298672\|gb\|AAF53886.1\| rho-type guanine exchange factor, isoform A [Drosophila melanogaster] [NCBI NR] gi\|24585417\|ref\|NP_724258.1\| rho-type guanine exchange factor, isoform B [Drosophila melanogaster] [NCBI NR] gi\|22946904\|gb\|AAF53887.2\| rho-type guanine exchange factor, isoform B [Drosophila melanogaster] [NCBI NR] gi\|17137224\|ref\|NP_477174.1\| rho-type guanine exchange factor, isoform A [Drosophila melanogaster] [NCBI NR] The gene rho-type guanine exchange factor is referred to in FlyBase by the symbol Dmel\rtGEF (CG10043, FBgn0015803). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 2L:20350436..20365254. It has the cytological map location 38C5. Based on sequence similarity, it is predicted to have molecular function</span>: guanyl-nucleotide exchange factor activity. There is experimental evidence that it is involved in the biological process</span>: regulation of synapse organization. 12 alleles are reported. The phenotypes of these alleles are annotated with: t-bar; NMJ bouton; postsynaptic membrane; synaptic vesicle. It has 5 annotated transcripts and 5 annotated polypeptides. [FlyBase] >CG10043-PB translation from_gene[CG10043 rtGEF FBgn0015803] seq_release:3 mol_weight=75007 cds_boundaries:(2L:20,325,152..20,334,229[+]) aa_length:687 transcript_info:[CG10043-RB seq_release:3] gene_info:[gene symbol:rtGEF FBgn0015803 gene_boundaries: [hmr_yeast5_DM3-1_pombe.fasta] >CG10043-PA translation from_gene[CG10043 rtGEF FBgn0015803] seq_release:3 mol_weight=75007 cds_boundaries:(2L:20,325,152..20,334,229[+]) aa_length:687 transcript_info:[CG10043-RA seq_release:3] gene_info:[gene symbol:rtGEF FBgn0015803 gene_boundaries: [hmr_yeast5_DM3-1_pombe.fasta] (Q9VIN1) RTGEF protein [DrosMelano7227.FASTAC.txt] (AE003666) rtGEF gene product [alt 2] [Drosophila melanogaster] [yeastflysequest.fasta] CG10043-PB, isoform B [Drosophila melanogaster]gi\|7298672\|gb\|AAF53886.1\| CG10043-PA, isoform A [Drosophila melanogaster]gi\|24585417\|ref\|NP_724258.1\| CG10043-PB [Drosophila melanogaster]gi\|17137224\|ref\|NP_477174.1\| CG10043-PA [Drosophila melanogaster] [nrdb_11152004_Chlamydomonas] type=protein; loc=2L:join(20355410..20355747,20355806..20356006,20356085..20356505,20356562..20356801,20360013..20360433,20360564..20360812,20364297..20364490); ID=FBpp0080888; name=rtGEF-PA; parent=FBgn0015803,FBtr0081356; dbxref=FlyBase:FBpp0080888,FlyB [fly-100309-contam.fasta] type=protein; loc=2L:join(20355410..20355747,20355806..20356006,20356085..20356505,20356562..20356801,20360013..20360433,20360564..20360812,20364297..20364490); ID=FBpp0080889; name=rtGEF-PB; parent=FBgn0015803,FBtr0081357; dbxref=FlyBase:FBpp0080889,FlyB [fly-100309-contam.fasta] CG10043-PB, isoform B [Drosophila melanogaster] [nr-271106-contam.fasta] rho-type guanine exchange factor CG10043-PB, isoform B [Drosophila melanogaster] [nr-271106-contam.fasta] rho-type guanine exchange factor CG10043-PA, isoform A [Drosophila melanogaster] [nr-271106-contam.fasta] CG10043-PA, isoform A [Drosophila melanogaster] [nr-271106-contam.fasta] type=protein; loc=2L:join(20355410..20355747,20355806..20356006,20356085..20356505,20356562..20356801,20360013..20360433,20360564..20360812,20364297..20364490); ID=FBpp0080888; name=rtGEF-PA; parent=FBgn0015803,FBtr0081356; dbxref=FlyBase:FBpp0080888,FlyBase_Annotation_IDs:CG10043-PA,GB_protein:AAF53886.1,REFSEQ:NP_477174,GB_protein:AAF53886; MD5=f273b4319adf717c1d66682a5b1a8590; length=687; release=r5.16; species=Dmel; [fly-contam-His-TEV-Tub4complex.fasta] type=protein; loc=2L:join(20355410..20355747,20355806..20356006,20356085..20356505,20356562..20356801,20360013..20360433,20360564..20360812,20364297..20364490); ID=FBpp0080889; name=rtGEF-PB; parent=FBgn0015803,FBtr0081357; dbxref=FlyBase:FBpp0080889,FlyBase_Annotation_IDs:CG10043-PB,GB_protein:AAF53887.2,REFSEQ:NP_724258,GB_protein:AAF53887; MD5=f273b4319adf717c1d66682a5b1a8590; length=687; release=r5.16; species=Dmel; [fly-contam-His-TEV-Tub4complex.fasta] type=protein; loc=2L:join(20355410..20355747,20355806..20356006,20356085..20356505,20356562..20356801,20360013..20360433,20360564..20360812,20364297..20364490); ID=FBpp0080888; name=rtGEF-PA; parent=FBgn0015803,FBtr0081356; dbxref=FlyBase:FBpp0080888,FlyBase_Annotation_IDs:CG10043-PA,GB_protein:AAF53886.1,REFSEQ:NP_477174,GB_protein:AAF53886; MD5=f273b4319adf717c1d66682a5b1a8590; length=687; release=r5.21; species=Dmel; [Other_drosophila_na_09-09-2009_reversed.fasta] type=protein; loc=2L:join(20355410..20355747,20355806..20356006,20356085..20356505,20356562..20356801,20360013..20360433,20360564..20360812,20364297..20364490); ID=FBpp0080889; name=rtGEF-PB; parent=FBgn0015803,FBtr0081357; dbxref=FlyBase:FBpp0080889,FlyBase_Annotation_IDs:CG10043-PB,GB_protein:AAF53887.2,REFSEQ:NP_724258,GB_protein:AAF53887; MD5=f273b4319adf717c1d66682a5b1a8590; length=687; release=r5.21; species=Dmel; [Other_drosophila_na_09-09-2009_reversed.fasta] Rho-type guanine exchange factor, isoform A OS=Drosophila melanogaster GN=rtGEF PE=1 SV=1 [UniProt_drosophila_07-01-2011_reversed.fasta] type=protein; loc=2L:join(20355410..20355747,20355806..20356006,20356085..20356505,20356562..20356801,20360013..20360433,20360564..20360812,20364297..20364490); ID=FBpp0080888; name=rtGEF-PA; parent=FBgn0015803,FBtr0081356; dbxref=FlyBase:FBpp0080888,FlyBase_Annotation_IDs:CG10043-PA,GB_protein:AAF53886.1,REFSEQ:NP_477174,GB_protein:AAF53886; MD5=f273b4319adf717c1d66682a5b1a8590; length=687; release=r5.46; species=Dmel; [fly-062812-sfps-sandra-contam.fasta] type=protein; loc=2L:join(20355410..20355747,20355806..20356006,20356085..20356505,20356562..20356801,20360013..20360433,20360564..20360812,20364297..20364490); ID=FBpp0080889; name=rtGEF-PB; parent=FBgn0015803,FBtr0081357; dbxref=FlyBase:FBpp0080889,FlyBase_Annotation_IDs:CG10043-PB,GB_protein:AAF53887.2,REFSEQ:NP_724258,GB_protein:AAF53887,FlyMine:FBpp0080889,modMine:FBpp0080889; MD5=f273b4319adf717c1d66682a5b1a8590; length=687; release=r5.46; species=Dmel; [fly-062812-sfps-sandra-contam.fasta] Rho-type guanine exchange factor, isoform A OS=Drosophila melanogaster GN=rtGEF PE=2 SV=1 [UniProt_D_Melanogaster_07132012_07-13-2012_reversed.fasta] type=protein; loc=2L:join(20355410..20355747,20355806..20356006,20356085..20356505,20356562..20356801,20360013..20360433,20360564..20360812,20364297..20364490); ID=FBpp0080888; name=RtGEF-PA; parent=FBgn0015803,FBtr0081356; dbxref=FlyBase:FBpp0080888,FlyBase_Annotation_IDs:CG10043-PA,GB_protein:AAF53886.1,REFSEQ:NP_477174,GB_protein:AAF53886; MD5=f273b4319adf717c1d66682a5b1a8590; length=687; release=r6.02; species=Dmel; [fly-2014-05-contam.fasta] type=protein; loc=2L:join(20355410..20355747,20355806..20356006,20356085..20356505,20356562..20356801,20360013..20360433,20360564..20360812,20364297..20364490); ID=FBpp0080889; name=RtGEF-PB; parent=FBgn0015803,FBtr0081357; dbxref=FlyBase:FBpp0080889,FlyBase_Annotation_IDs:CG10043-PB,GB_protein:AAF53887.2,REFSEQ:NP_724258,GB_protein:AAF53887,FlyMine:FBpp0080889,modMine:FBpp0080889; MD5=f273b4319adf717c1d66682a5b1a8590; length=687; release=r6.02; species=Dmel; [fly-2014-05-contam.fasta] type=protein; loc=2L:join(20355410..20355747,20355806..20356006,20356085..20356505,20356562..20356801,20360013..20360433,20360564..20360812,20364297..20364490); ID=FBpp0080888; name=RtGEF-PA; parent=FBgn0015803,FBtr0081356; dbxref=FlyBase:FBpp0080888,FlyBase_Annotation_IDs:CG10043-PA,GB_protein:AAF53886.1,REFSEQ:NP_477174,GB_protein:AAF53886; MD5=f273b4319adf717c1d66682a5b1a8590; length=687; release=r6.07; species=Dmel; [fly-08202015-contam.fasta] type=protein; loc=2L:join(20355410..20355747,20355806..20356006,20356085..20356505,20356562..20356801,20360013..20360433,20360564..20360812,20364297..20364490); ID=FBpp0080889; name=RtGEF-PB; parent=FBgn0015803,FBtr0081357; dbxref=FlyBase:FBpp0080889,FlyBase_Annotation_IDs:CG10043-PB,GB_protein:AAF53887.2,REFSEQ:NP_724258,GB_protein:AAF53887,FlyMine:FBpp0080889,modMine:FBpp0080889; MD5=f273b4319adf717c1d66682a5b1a8590; length=687; release=r6.07; species=Dmel; [fly-08202015-contam.fasta] Isoform of A8DZ19, Rho-type guanine nucleotide exchange factor, isoform A OS=Drosophila melanogaster GN=RtGEF PE=1 SV=1 [DROME.fasta.20160308] FBpp0080888 type=protein; loc=2L:join(20355410..20355747,20355806..20356006,20356085..20356505,20356562..20356801,20360013..20360433,20360564..20360812,20364297..20364490); ID=FBpp0080888; name=RtGEF-PA; parent=FBgn0015803,FBtr0081356; dbxref=FlyBase:FBpp0080888,FlyBase_Annotation_IDs:CG10043-PA,GB_protein:AAF53886.1,REFSEQ:NP_477174,GB_protein:AAF53886; MD5=f273b4319adf717c1d66682a5b1a8590; length=687; release=r6.09; species=Dmel; [dmel-all-translation-r6.09.fasta] FBpp0080889 type=protein; loc=2L:join(20355410..20355747,20355806..20356006,20356085..20356505,20356562..20356801,20360013..20360433,20360564..20360812,20364297..20364490); ID=FBpp0080889; name=RtGEF-PB; parent=FBgn0015803,FBtr0081357; dbxref=FlyBase:FBpp0080889,FlyBase_Annotation_IDs:CG10043-PB,GB_protein:AAF53887.2,REFSEQ:NP_724258,GB_protein:AAF53887,FlyMine:FBpp0080889,modMine:FBpp0080889; MD5=f273b4319adf717c1d66682a5b1a8590; length=687; release=r6.09; species=Dmel; [dmel-all-translation-r6.09.fasta] [fly-122215-dmel-6-09-contam.fasta] type=protein; loc=2L:join(20355410..20355747,20355806..20356006,20356085..20356505,20356562..20356801,20360013..20360433,20360564..20360812,20364297..20364490); ID=FBpp0080888; name=RtGEF-PA; parent=FBgn0015803,FBtr0081356; dbxref=FlyBase:FBpp0080888,FlyBase_Annotation_IDs:CG10043-PA,GB_protein:AAF53886.1,REFSEQ:NP_477174,GB_protein:AAF53886,UniProt/TrEMBL:Q9VIN1; MD5=f273b4319adf717c1d66682a5b1a8590; length=687; release=r6.14; species=Dmel; [fly-dmel-jan2017-sandracontam.fasta] type=protein; loc=2L:join(20355410..20355747,20355806..20356006,20356085..20356505,20356562..20356801,20360013..20360433,20360564..20360812,20364297..20364490); ID=FBpp0080889; name=RtGEF-PB; parent=FBgn0015803,FBtr0081357; dbxref=FlyBase:FBpp0080889,FlyBase_Annotation_IDs:CG10043-PB,GB_protein:AAF53887.2,REFSEQ:NP_724258,GB_protein:AAF53887,UniProt/TrEMBL:Q9VIN1,FlyMine:FBpp0080889,modMine:FBpp0080889; MD5=f273b4319adf717c1d66682a5b1a8590; length=687; release=r6.14; species=Dmel; [fly-dmel-jan2017-sandracontam.fasta]
Organism:	Drosophila melanogaster
Length:	687 amino acids
Gene Ontology:
Cellular Component:	intracellular [IEA]
Biological Process:	regulation of Rho protein signal transduction [IEA] regulation of synapse organization [IMP]
Molecular Function:	guanyl-nucleotide exchange factor activity [ISS] Rho guanyl-nucleotide exchange factor activity [IEA]

Sequence:

Sequence:
[PDR BLAST]
[ProtParam]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MDQPLVVQAE YSFMGSNNDE LCFQKGDVIT VTQREDGGWW EGTLNDKTGW FPSNYVNECK  60
   61 VQLPLTETIR PPEEIQEYRS VVLKDLLDSE RAHVAELQGL LENFLEPMQQ TQILSQDEYA 120
  121 QLMCNFVEIV RTHEDLLIQI EECNDRVGKL FLTSAPLMKK VHQAYCAAHP KAIVILDKYK 180
  181 DELEKYMERQ GAATPGLLVL TTGLSKPFRR LDKYSAMLQE LERHMESSHP DRGDTQRSVA 240
  241 VYKDIAATCS ATRRQKELEL QVLTGPVRGW QGQELSTLGD IIHMGSVAVG ADHRDRYFVL 300
  301 FPQTLLFLSV SQRMSAFIYE GKLPLTGIIV NRLEDTDALK NAFEISSPLI DRIVAVCQGP 360
  361 NEANKWVELL NANNPSLPMG IKRQLSNLSN SSLGHLNAAH MSPPSSHILL PPGGRPPATP 420
  421 SSIPAGSSSG GSHSHQGSPA TNSMSHHKRS QSFNHHLSYN QYTPTQPPPH HLHPPQPPSL 480
  481 PSHLGASGPR SSSAQTPNSK TAAPLQASSM DASPAIQAAA AAAAAAVGMG VPSARKGSTK 540
  541 ANWTISCLRP TPPLRPSLLN ATSGSGSGSG GSGGGGSSSS NALASYCSGR KNQPTYEEDA 600
  601 LVLRVFEAYC AAYQNNARNT IHSGLENEDM TPTLRQLWTA IRQMQQDMSQ IKLQINEERA 660
  661 LRADLQQLLM QHLETSSVSS GANTPKC

Protein Complex Data

No complex found for this protein.

Mass Spectrometry Data

No mass spectrometry results found for this protein.

Yeast Two-Hybrid Data

The following interactions contain this protein:

NOT SHOWING SINGLE HITS. [ Show Single Hits ]

[View our yeast two-hybrid interpretation guidelines.]

No yeast two-hybrid interactions found for this protein.

Protein predicted to be:	GLOBULAR (No transmembrane regions or signal peptide)
Confidence of classification:	0.79

Protein Overview: rtGEF-PB, rtGEF-PA

Protein Complex Data

Mass Spectrometry Data

Yeast Two-Hybrid Data

Microscopy / Localization Data

Protein Structure Data

Philius Transmembrane Prediction: