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Protein Overview: FBpp0304598, Top2-PA

General Information:
Name(s) found: FBpp0304598 [FlyBase]
Top2-PA / FBpp0080825 [FlyBase]
Description(s) found:
Found 30 descriptions.
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  • type=protein; loc=2L:complement(19447738..19448061,19448143..19451180,19451247..19451670,19451728..19452285); ID=FBpp0304598; name=Top2-PB; parent=FBgn0003732,FBtr0332320; dbxref=FlyBase:FBpp0304598,FlyBase_Annotation_IDs:CG10223-PB,REFSEQ:NP_001260580,GB_protein:AGB93115; MD5=44a7e3677ef6ad5222f7811934e0e1c9; length=1447; release=r5.56; species=Dmel; [FlyBase]
  • The gene Topoisomerase 2 is referred to in FlyBase by the symbol Dmel\Top2 (CG10223, FBgn0003732). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 2L:19447362..19453507. It has the cytological map location 37E1. There is experimental evidence that it has the molecular function</span>: DNA topoisomerase (ATP-hydrolyzing) activity; satellite DNA binding; mRNA binding; rDNA binding; four-way junction DNA binding; SUMO binding; DNA binding. There is experimental evidence that it is involved in the biological process</span>: mitotic chromosome condensation; metaphase plate congression; DNA topological change; mitotic spindle organization; sister chromatid segregation; chromatin silencing. 7 alleles are reported. No phenotypic data is available. It has one annotated transcript and one annotated polypeptide. [FlyBase]
    • Organism: Drosophila melanogaster
    Length: 1447 amino acids

    Gene Ontology:
    Cellular Component: nucleus [IDA][NAS]
    insoluble fraction [IDA]
    soluble fraction [IDA]
    [NOT]ACF complex [IDA]
    cytoplasm [IDA]
    chromosome [IDA]
    chromatin accessibility complex [IDA]
    Biological Process: sister chromatid segregation [IDA]
    metaphase plate congression [IDA]
    mitotic chromosome condensation [IMP]
    mitotic spindle organization [IMP]
    mitosis [TAS]
    DNA topological change [IDA]
    chromatin silencing [IDA]
    DNA metabolic process [IEA]
    meiosis [TAS]
    Molecular Function: DNA binding [IDA]
    ATP binding [IEA]
    SUMO binding [IPI]
    rDNA binding [IDA]
    mRNA binding [IDA]
    DNA topoisomerase (ATP-hydrolyzing) activity [IDA][NAS]
    four-way junction DNA binding [IDA]
    satellite DNA binding [IDA]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MENGNKALSI EQMYQKKSQL EHILLRPDSY IGSVEFTKEL MWVYDNSQNR MVQKEISFVP  60
   61 GLYKIFDEIL VNAADNKQRD KSMNTIKIDI DPERNMVSVW NNGQGIPVTM HKEQKMYVPT 120
  121 MIFGHLLTSS NYNDDEKKVT GGRNGYGAKL CNIFSTSFTV ETATREYKKS FKQTWGNNMG 180
  181 KASDVQIKDF NGTDYTRITF SPDLAKFKMD RLDEDIVALM SRRAYDVAAS SKGVSVFLNG 240
  241 NKLGVRNFKD YIDLHIKNTD DDSGPPIKIV HEVANERWEV ACCPSDRGFQ QVSFVNSIAT 300
  301 YKGGRHVDHV VDNLIKQLLE VLKKKNKGGI NIKPFQVRNH LWVFVNCLIE NPTFDSQTKE 360
  361 NMTLQQKGFG SKCTLSEKFI NNMSKSGIVE SVLAWAKFKA QNDIAKTGGR KSSKIKGIPK 420
  421 LEDANEAGGK NSIKCTLILT EGDSAKSLAV SGLGVIGRDL YGVFPLRGKL LNVREANFKQ 480
  481 LSENAEINNL CKIIGLQYKK KYLTEDDLKT LRYGKVMIMT DQDQDGSHIK GLLINFIHTN 540
  541 WPELLRLPFL EEFITPIVKA TKKNEELSFY SLPEFEEWKN DTANHHTYNI KYYKGLGTST 600
  601 SKEAKEYFQD MDRHRILFKY DGSVDDESIV MAFSKKHIES RKVWLTNHMD EVKRRKELGL 660
  661 PERYLYTKGT KSITYADFIN LELVLFSNAD NERSIPSLVD GLKPGQRKVM FTCFKRNDKR 720
  721 EVKVAQLSGS VAEMSAYHHG EVSLQMTIVN LAQNFVGANN INLLEPRGQF GTRLSGGKDC 780
  781 ASARYIFTIM SPLTRLIYHP LDDPLLDYQV DDGQKIEPLW YLPIIPMVLV NGAEGIGTGW 840
  841 STKISNYNPR EIMKNLRKMI NGQEPSVMHP WYKNFLGRME YVSDGRYIQT GNIQILSGNR 900
  901 LEISELPVGV WTQNYKENVL EPLSNGTEKV KGIISEYREY HTDTTVRFVI SFAPGEFERI 960
  961 HAEEGGFYRV FKLTTTLSTN QMHAFDQNNC LRRFPTAIDI LKEYYKLRRE YYARRRDFLV1020
 1021 GQLTAQADRL SDQARFILEK CEKKLVVENK QRKAMCDELL KRGYRPDPVK EWQRRIKMED1080
 1081 AEQADEEDEE EEEAAPSVSS KAKKEKEVDP EKAFKKLTDV KKFDYLLGMS MWMLTEEKKN1140
 1141 ELLKQRDTKL SELESLRKKT PEMLWLDDLD ALESKLNEVE EKERAEEQGI NLKTAKALKG1200
 1201 QKSASAKGRK VKSMGGGAGA GDVFPDPDGE PVEFKITEEI IKKMAAAAKV AQAAKEPKKP1260
 1261 KEPKEPKVKK EPKGKQIKAE PDASGDEVDE FDAMVEGGSK TSPKAKKAVV KKEPGEKKPR1320
 1321 QKKENGGGLK QSKIDFSKAK AKKSDDDVEE VTPRAERPGR RQASKKIDYS SLFSDEEEDG1380
 1381 GNVGSDDDGN ASDDDSPKRP AKRGREDESS GGAKKKAPPK KRRAVIESDD DDIEIDEDDD1440
 1441 DDSDFNC

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data



    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle