Protein Overview: rk-PA

General Information:
Name(s) found:	rk-PA / FBpp0080183 [FlyBase]
Description(s) found: SHOW ONLY BEST	gi\|22946467\|gb\|AAN10866.1\| rickets, isoform D [Drosophila melanogaster] [NCBI NR] gi\|22946466\|gb\|AAN10865.1\| rickets, isoform C [Drosophila melanogaster] [NCBI NR] gi\|22946465\|gb\|AAN10864.1\| rickets, isoform B [Drosophila melanogaster] [NCBI NR] gi\|22946464\|gb\|AAF53367.3\| rickets, isoform A [Drosophila melanogaster] [NCBI NR] gi\|19550088\|ref\|NP_599104.1\| rickets, isoform D [Drosophila melanogaster] [NCBI NR] gi\|19550086\|ref\|NP_599103.1\| rickets, isoform C [Drosophila melanogaster] [NCBI NR] gi\|19550084\|ref\|NP_599102.1\| rickets, isoform B [Drosophila melanogaster] [NCBI NR] gi\|17136436\|ref\|NP_476702.1\| rickets, isoform A [Drosophila melanogaster] [NCBI NR] The gene rickets is referred to in FlyBase by the symbol Dmel\rk (CG8930, FBgn0003255). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 2L:13982726..14001252. It has the cytological map location 34E5-34E6. Based on sequence similarity, it is predicted to have molecular function</span>: G-protein coupled receptor activity; protein-hormone receptor activity; neuropeptide receptor activity. There is experimental evidence that it is involved in the biological process</span>: epithelial to mesenchymal transition; regulation of chitin-based cuticle tanning. 31 alleles are reported. The phenotypes of these alleles are annotated with: abdomen; leg; macrochaeta; adult cuticle; metathoracic leg; haltere; tarsal segment; wing; posterior scutellar bristle. It has 2 annotated transcripts and 2 annotated polypeptides. [FlyBase] >CG8930-PD translation from_gene[CG8930 rk FBgn0003255] seq_release:3 mol_weight=150775 cds_boundaries:(2L:13,965,577..13,975,639[-]) aa_length:1360 transcript_info:[CG8930-RD seq_release:3] gene_info:[gene symbol:rk FBgn0003255 gene_boundaries:(2L:13, [hmr_yeast5_DM3-1_pombe.fasta] >CG8930-PC translation from_gene[CG8930 rk FBgn0003255] seq_release:3 mol_weight=150775 cds_boundaries:(2L:13,965,577..13,975,639[-]) aa_length:1360 transcript_info:[CG8930-RC seq_release:3] gene_info:[gene symbol:rk FBgn0003255 gene_boundaries:(2L:13, [hmr_yeast5_DM3-1_pombe.fasta] >CG8930-PB translation from_gene[CG8930 rk FBgn0003255] seq_release:3 mol_weight=150775 cds_boundaries:(2L:13,965,577..13,975,639[-]) aa_length:1360 transcript_info:[CG8930-RB seq_release:3] gene_info:[gene symbol:rk FBgn0003255 gene_boundaries:(2L:13, [hmr_yeast5_DM3-1_pombe.fasta] >CG8930-PA translation from_gene[CG8930 rk FBgn0003255] seq_release:3 mol_weight=150775 cds_boundaries:(2L:13,965,577..13,975,639[-]) aa_length:1360 transcript_info:[CG8930-RA seq_release:3] gene_info:[gene symbol:rk FBgn0003255 gene_boundaries:(2L:13, [hmr_yeast5_DM3-1_pombe.fasta] (AAF53367) CG8930-PA (CG8930-PB) [DrosMelano7227.FASTAC.txt] CG8930-PD, isoform D [Drosophila melanogaster]gi\|22946466\|gb\|AAN10865.1\| CG8930-PC, isoform C [Drosophila melanogaster]gi\|22946465\|gb\|AAN10864.1\| CG8930-PB, isoform B [Drosophila melanogaster]gi\|22946464\|gb\|AAF53367.3\| CG8930-PA, isoform A [Drosophila [nrdb_11152004_Chlamydomonas] type=protein; loc=2L:complement(13983422..13983741,13983799..13985580,13985637..13986004,13986066..13986209,13986267..13986332,13986398..13986538,13986594..13986731,13987821..13987889,13989637..13989708,13989783..13989854,13990446..13990589,13990915..1399 [fly-100309-contam.fasta] CG8930-PA, isoform A [Drosophila melanogaster] [nr-271106-contam.fasta] rickets CG8930-PC, isoform C [Drosophila melanogaster] [nr-271106-contam.fasta] CG8930-PB, isoform B [Drosophila melanogaster] [nr-271106-contam.fasta] rickets CG8930-PD, isoform D [Drosophila melanogaster] [nr-271106-contam.fasta] rickets CG8930-PB, isoform B [Drosophila melanogaster] [nr-271106-contam.fasta] CG8930-PC, isoform C [Drosophila melanogaster] [nr-271106-contam.fasta] CG8930-PD, isoform D [Drosophila melanogaster] [nr-271106-contam.fasta] rickets CG8930-PA, isoform A [Drosophila melanogaster] [nr-271106-contam.fasta] type=protein; loc=2L:complement(13983422..13983741,13983799..13985580,13985637..13986004,13986066..13986209,13986267..13986332,13986398..13986538,13986594..13986731,13987821..13987889,13989637..13989708,13989783..13989854,13990446..13990589,13990915..13991058,13991642..13991713,13992937..13993487); ID=FBpp0080183; name=rk-PA; parent=FBgn0003255,FBtr0080610; dbxref=FlyBase:FBpp0080183,FlyBase_Annotation_IDs:CG8930-PA,GB_protein:AAF53367.3,REFSEQ:NP_476702,GB_protein:AAF53367; MD5=140e12c5cd79c8b0e19fd94c8c9138fa; length=1360; release=r5.16; species=Dmel; [fly-contam-His-TEV-Tub4complex.fasta] type=protein; loc=2L:complement(13983422..13983741,13983799..13985580,13985637..13986004,13986066..13986209,13986267..13986332,13986398..13986538,13986594..13986731,13987821..13987889,13989637..13989708,13989783..13989854,13990446..13990589,13990915..13991058,13991642..13991713,13992937..13993487); ID=FBpp0080184; name=rk-PB; parent=FBgn0003255,FBtr0080611; dbxref=FlyBase:FBpp0080184,FlyBase_Annotation_IDs:CG8930-PB,GB_protein:AAN10864.1,REFSEQ:NP_599102,GB_protein:AAN10864; MD5=140e12c5cd79c8b0e19fd94c8c9138fa; length=1360; release=r5.16; species=Dmel; [fly-contam-His-TEV-Tub4complex.fasta] type=protein; loc=2L:complement(13983422..13983741,13983799..13985580,13985637..13986004,13986066..13986209,13986267..13986332,13986398..13986538,13986594..13986731,13987821..13987889,13989637..13989708,13989783..13989854,13990446..13990589,13990915..13991058,13991642..13991713,13992937..13993487); ID=FBpp0080185; name=rk-PC; parent=FBgn0003255,FBtr0080612; dbxref=FlyBase:FBpp0080185,FlyBase_Annotation_IDs:CG8930-PC,GB_protein:AAN10865.1,REFSEQ:NP_599103,GB_protein:AAN10865; MD5=140e12c5cd79c8b0e19fd94c8c9138fa; length=1360; release=r5.16; species=Dmel; [fly-contam-His-TEV-Tub4complex.fasta] type=protein; loc=2L:complement(13983422..13983741,13983799..13985580,13985637..13986004,13986066..13986209,13986267..13986332,13986398..13986538,13986594..13986731,13987821..13987889,13989637..13989708,13989783..13989854,13990446..13990589,13990915..13991058,13991642..13991713,13992937..13993487); ID=FBpp0080186; name=rk-PD; parent=FBgn0003255,FBtr0080613; dbxref=FlyBase:FBpp0080186,FlyBase_Annotation_IDs:CG8930-PD,GB_protein:AAN10866.1,REFSEQ:NP_599104,GB_protein:AAN10866; MD5=140e12c5cd79c8b0e19fd94c8c9138fa; length=1360; release=r5.16; species=Dmel; [fly-contam-His-TEV-Tub4complex.fasta] type=protein; loc=2L:complement(13983422..13983741,13983799..13985580,13985637..13986004,13986066..13986209,13986267..13986332,13986398..13986538,13986594..13986731,13987821..13987889,13989637..13989708,13989783..13989854,13990446..13990589,13990915..13991058,13991642..13991713,13992937..13993487); ID=FBpp0080183; name=rk-PA; parent=FBgn0003255,FBtr0080610; dbxref=FlyBase:FBpp0080183,FlyBase_Annotation_IDs:CG8930-PA,GB_protein:AAF53367.3,REFSEQ:NP_476702,GB_protein:AAF53367; MD5=140e12c5cd79c8b0e19fd94c8c9138fa; length=1360; release=r5.21; species=Dmel; [Other_drosophila_na_09-09-2009_reversed.fasta] Rickets, isoform A OS=Drosophila melanogaster GN=rk PE=2 SV=1 [UniProt_drosophila_07-01-2011_reversed.fasta] type=protein; loc=2L:complement(13983422..13983741,13983799..13985580,13985637..13986004,13986066..13986209,13986267..13986332,13986398..13986538,13986594..13986731,13987821..13987889,13989637..13989708,13989783..13989854,13990446..13990589,13990915..13991058,13991642..13991713,13992937..13993487); ID=FBpp0080183; name=rk-PA; parent=FBgn0003255,FBtr0080610; dbxref=FlyBase:FBpp0080183,FlyBase_Annotation_IDs:CG8930-PA,GB_protein:AAF53367.3,REFSEQ:NP_476702,GB_protein:AAF53367,FlyMine:FBpp0080183,modMine:FBpp0080183; MD5=140e12c5cd79c8b0e19fd94c8c9138fa; length=1360; release=r5.46; species=Dmel; [fly-062812-sfps-sandra-contam.fasta] type=protein; loc=2L:complement(join(13992937..13993487,13991642..13991713,13990915..13991058,13990446..13990589,13989783..13989854,13989637..13989708,13987821..13987889,13986594..13986731,13986398..13986538,13986267..13986332,13986066..13986209,13985637..13986004,13983799..13985580,13983422..13983741)); ID=FBpp0080183; name=rk-PA; parent=FBgn0003255,FBtr0080610; dbxref=FlyBase:FBpp0080183,FlyBase_Annotation_IDs:CG8930-PA,GB_protein:AAF53367.3,REFSEQ:NP_476702,GB_protein:AAF53367,FlyMine:FBpp0080183,modMine:FBpp0080183; MD5=140e12c5cd79c8b0e19fd94c8c9138fa; length=1360; release=r6.02; species=Dmel; [fly-2014-05-contam.fasta] type=protein; loc=2L:complement(join(13992937..13993487,13991642..13991713,13990915..13991058,13990446..13990589,13989783..13989854,13989637..13989708,13987821..13987889,13986594..13986731,13986398..13986538,13986267..13986332,13986066..13986209,13985637..13986004,13983799..13985580,13983422..13983741)); ID=FBpp0080183; name=rk-PA; parent=FBgn0003255,FBtr0080610; dbxref=FlyBase:FBpp0080183,FlyBase_Annotation_IDs:CG8930-PA,GB_protein:AAF53367.3,REFSEQ:NP_476702,GB_protein:AAF53367,FlyMine:FBpp0080183,modMine:FBpp0080183; MD5=140e12c5cd79c8b0e19fd94c8c9138fa; length=1360; release=r6.07; species=Dmel; [fly-08202015-contam.fasta] Rickets OS=Drosophila melanogaster GN=rk PE=4 SV=1 [DROME.fasta.20160308] FBpp0080183 type=protein; loc=2L:complement(join(13992937..13993487,13991642..13991713,13990915..13991058,13990446..13990589,13989783..13989854,13989637..13989708,13987821..13987889,13986594..13986731,13986398..13986538,13986267..13986332,13986066..13986209,13985637..13986004,13983799..13985580,13983422..13983741)); ID=FBpp0080183; name=rk-PA; parent=FBgn0003255,FBtr0080610; dbxref=FlyBase:FBpp0080183,FlyBase_Annotation_IDs:CG8930-PA,GB_protein:AAF53367.3,REFSEQ:NP_476702,GB_protein:AAF53367,FlyMine:FBpp0080183,modMine:FBpp0080183; MD5=140e12c5cd79c8b0e19fd94c8c9138fa; length=1360; release=r6.09; species=Dmel; [dmel-all-translation-r6.09.fasta] [fly-122215-dmel-6-09-contam.fasta] type=protein; loc=2L:complement(join(13992937..13993487,13991642..13991713,13990915..13991058,13990446..13990589,13989783..13989854,13989637..13989708,13987821..13987889,13986594..13986731,13986398..13986538,13986267..13986332,13986066..13986209,13985637..13986004,13983799..13985580,13983422..13983741)); ID=FBpp0080183; name=rk-PA; parent=FBgn0003255,FBtr0080610; dbxref=FlyBase:FBpp0080183,FlyBase_Annotation_IDs:CG8930-PA,GB_protein:AAF53367.3,REFSEQ:NP_476702,GB_protein:AAF53367,UniProt/TrEMBL:Q7KTA0,FlyMine:FBpp0080183,modMine:FBpp0080183; MD5=140e12c5cd79c8b0e19fd94c8c9138fa; length=1360; release=r6.14; species=Dmel; [fly-dmel-jan2017-sandracontam.fasta]
Organism:	Drosophila melanogaster
Length:	1360 amino acids
Gene Ontology:
Cellular Component:	integral to membrane [IEA][ISS] plasma membrane [NAS]
Biological Process:	G-protein coupled receptor protein signaling pathway [IEA][ISS] regulation of chitin-based cuticle tanning [IMP] epithelial to mesenchymal transition [IMP]
Molecular Function:	G-protein coupled receptor activity [ISS][NAS] protein binding [IEA] neuropeptide receptor activity [ISS] protein-hormone receptor activity [IEA][ISS]

Sequence:

Sequence:
[PDR BLAST]
[ProtParam]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MAARCRWSWR LALCPLLLQL LLQLLLLPPS AMGHDETKEN PAPDMQNSQE QEPYVHLQHL  60
   61 QQQQQQNPQT VQQLSQITVN RTSKSASVTP TGIRENVMLP SADPEKEAQI LYEKSLQEYH 120
  121 GSQLSTASTA TDVIAGKRTL HSICERWLQK HCHCTGSLEV LRLSCRGIGI LAVPVNLPNE 180
  181 VVVLDLGNNN LTKLEANSFF MAPNLEELTL SDNSIINMDP NAFYGLAKLK RLSLQNCGLK 240
  241 SLPPQSFQGL AQLTSLQLNG NALVSLDGDC LGHLQKLRTL RLEGNLFYRI PTNALAGLRT 300
  301 LEALNLGSNL LTIINDEDFP RMPNLIVLLL KRNQIMKISA GALKNLTALK VLELDDNLIS 360
  361 SLPEGLSKLS QLQELSITSN RLRWINDTEL PRSMQMLDMR ANPLSTISPG AFRGMSKLRK 420
  421 LILSDVRTLR SFPELEACHA LEILKLDRAG IQEVPANLCR QTPRLKSLEL KTNSLKRIPN 480
  481 LSSCRDLRLL DLSSNQIEKI QGKPFNGLKQ LNDLLLSYNR IKALPQDAFQ GIPKLQLLDL 540
  541 EGNEISYIHK EAFSGFTALE DLNLGNNIFP ELPESGLRAL LHLKTFNNPK LREFPPPDTF 600
  601 PRIQTLILSY AYHCCAFLPL VAMSSQKKTS QVQEAVLFPS DAEFDMTLWN NSMMNIWPQM 660
  661 HNLSKQLGAS MHDPWETAIN FNEEQLQTQT GGQIATSYME EYFEEHDVSG PATGYGFGTG 720
  721 LFSGMSTEDF QPGSVQCLPM PGPFLPCADL FDWWTLRCGV WVVFLLSLLG NGTVVFVLLC 780
  781 SRSKMDVPRF LVCNLAAADF FMGIYLGILA IVDAATLGEF RMFAIPWQMS VLCQLSGFLA 840
  841 VLSSELSVYT LAVITLERNY AITHAIHLNK RLSLKQAGYI MSVGWVFALI MALMPLVGVS 900
  901 DYRKFAVCLP FETTTGPASL TYVISLMFIN GCAFLTLMGC YLKMYWAIRG SQAWNTNDSR 960
  961 IAKRMALLVF TDFLCWSPIA FFSITAIFGL QLISLEQAKI FTVFVLPLNS CCNPFLYAIM1020
 1021 TKQFKKDCVT LCKHFEESRV VGGGGPGGRG AVARTKRGDL PPPLLPAAAV AHPPGCRCLR1080
 1081 MLPSEMPNWH KMEQTPSMWQ RLRTFCCGEN RRRRKQRRQP QQRRQRAYTA AAANPYQYQF1140
 1141 AELRQQRQNR ASSISSENFC SSRSSSWRHG PPSSAPVPPG NCSMPLKMLE PHAHPHGHGR1200
 1201 RRHSAWLITR KTSQDSNLSS SRNDSSASAT TASTSTFRLS RSSAGSSTPL PSIIAHNGKA1260
 1261 QLDAVKPRLV RQEAVQEEED SSPPRLGVRF LPTIPSAADS SVVMEDGDSA NTGVASFLGM1320
 1321 PLPGASSGFL IAPTTAATTS PPPVVLQPAK PPPDPNDAPL

Protein Complex Data

No complex found for this protein.

Mass Spectrometry Data

No mass spectrometry results found for this protein.

Yeast Two-Hybrid Data

The following interactions contain this protein:

NOT SHOWING SINGLE HITS. [ Show Single Hits ]

[View our yeast two-hybrid interpretation guidelines.]

No yeast two-hybrid interactions found for this protein.

Protein Overview: rk-PA

Protein Complex Data

Mass Spectrometry Data

Yeast Two-Hybrid Data

Microscopy / Localization Data

Protein Structure Data

Philius Transmembrane Prediction: