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Protein Overview: esc-PA

General Information:
Name(s) found: esc-PA / FBpp0079907 [FlyBase]
Description(s) found:
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  • gi|7297878|gb|AAF53124.1| extra sexcombs [Drosophila melanogaster] [NCBI NR]
  • gi|29427425|sp|Q24338.1|ESC_DROME RecName: Full=Polycomb protein esc; AltName: Full=Protein extra sex combs [NCBI NR]
  • pir||S58672 extra sex combs protein - fruit fly (Drosophila melanogaster) [NCBI NR]
  • gi|17862928|gb|AAL39941.1| SD03549p [Drosophila melanogaster] [NCBI NR]
  • gi|17137672|ref|NP_477431.1| extra sexcombs [Drosophila melanogaster] [NCBI NR]
  • gi|1050997|gb|AAA86427.1| extra sex combs [Drosophila melanogaster] [NCBI NR]
  • Polycomb protein esc OS=Drosophila melanogaster GN=esc PE=1 SV=1 [Swiss-Prot]
  • The gene extra sexcombs is referred to in FlyBase by the symbol Dmel\esc (CG14941, FBgn0000588). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 2L:11827180..11829402. It has the cytological map location 33A2. There is experimental evidence that it has the molecular function</span>: protein binding. There is experimental evidence that it is involved in the biological process</span>: gene silencing; histone methylation; dendrite morphogenesis; neuron development; muscle organ development; chromatin silencing. 55 alleles are reported. The phenotypes of these alleles are annotated with 35 unique terms, many of which group under: embryonic segment; embryonic abdomen; adult segment; embryonic tagma; thoracic segment; abdominal segment 7; embryonic head; peripheral nervous system; embryonic thoracic segment; embryonic abdominal segment 4; abdominal segment 10; antennal segment; midgut constriction. It has one annotated transcript and one annotated polypeptide. [FlyBase]
  • >CG14941-PA translation from_gene[CG14941 esc FBgn0000588] seq_release:3 mol_weight=47988 cds_boundaries:(2L:11,816,334..11,818,106[-]) aa_length:425 transcript_info:[CG14941-RA seq_release:3] gene_info:[gene symbol:esc FBgn0000588 gene_boundaries:(2L: [hmr_yeast5_DM3-1_pombe.fasta]
  • (Q24338) Polycomb protein Esc (Extra sex combs protein) [DrosMelano7227.FASTAC.txt]
  • (AE003634) esc gene product [Drosophila melanogaster] [yeastflysequest.fasta]
  • CG14941-PA [Drosophila melanogaster]gi|17862928|gb|AAL39941.1| SD03549p [Drosophila melanogaster]gi|17137672|ref|NP_477431.1| CG14941-PA [Drosophila melanogaster]gi|2133657|pir||S58672 extra sex combs protein - fruit fly (Drosophila melanogaster)gi|29 [nrdb_11152004_Chlamydomonas]
  • type=protein; loc=2L:complement(11827460..11828371,11828736..11828907,11828970..11829103,11829176..11829235); ID=FBpp0079907; name=esc-PA; parent=FBgn0000588,FBtr0080325; dbxref=FlyBase:FBpp0079907,FlyBase_Annotation_IDs:CG14941-PA,GB_protein:AAF53124.1,R [fly-100309-contam.fasta]
  • extra sex combs gene product [nr-271106-contam.fasta]
  • extra sexcombs CG14941-PA [Drosophila melanogaster] [nr-271106-contam.fasta]
  • SD03549p [Drosophila melanogaster] [nr-271106-contam.fasta]
  • Polycomb protein esc (Protein extra sex combs) [nr-271106-contam.fasta]
  • CG14941-PA [Drosophila melanogaster] [nr-271106-contam.fasta]
  • type=protein; loc=2L:complement(11827460..11828371,11828736..11828907,11828970..11829103,11829176..11829235); ID=FBpp0079907; name=esc-PA; parent=FBgn0000588,FBtr0080325; dbxref=FlyBase:FBpp0079907,FlyBase_Annotation_IDs:CG14941-PA,GB_protein:AAF53124.1,REFSEQ:NP_477431,GB_protein:AAF53124; MD5=81123010ab0b3de5e540cb6a54645a3c; length=425; release=r5.16; species=Dmel; [fly-contam-His-TEV-Tub4complex.fasta]
  • type=protein; loc=2L:complement(11827460..11828371,11828736..11828907,11828970..11829103,11829176..11829235); ID=FBpp0079907; name=esc-PA; parent=FBgn0000588,FBtr0080325; dbxref=FlyBase:FBpp0079907,FlyBase_Annotation_IDs:CG14941-PA,GB_protein:AAF53124.1,REFSEQ:NP_477431,GB_protein:AAF53124; MD5=81123010ab0b3de5e540cb6a54645a3c; length=425; release=r5.21; species=Dmel; [Other_drosophila_na_09-09-2009_reversed.fasta]
  • type=protein; loc=2L:complement(11827460..11828371,11828736..11828907,11828970..11829103,11829176..11829235); ID=FBpp0079907; name=esc-PA; parent=FBgn0000588,FBtr0080325; dbxref=FlyBase:FBpp0079907,FlyBase_Annotation_IDs:CG14941-PA,GB_protein:AAF53124.1,REFSEQ:NP_477431,GB_protein:AAF53124,FlyMine:FBpp0079907,modMine:FBpp0079907; MD5=81123010ab0b3de5e540cb6a54645a3c; length=425; release=r5.46; species=Dmel; [fly-062812-sfps-sandra-contam.fasta]
  • type=protein; loc=2L:complement(join(11829176..11829235,11828970..11829103,11828736..11828907,11827460..11828371)); ID=FBpp0079907; name=esc-PA; parent=FBgn0000588,FBtr0080325; dbxref=FlyBase:FBpp0079907,FlyBase_Annotation_IDs:CG14941-PA,GB_protein:AAF53124.1,REFSEQ:NP_477431,GB_protein:AAF53124,FlyMine:FBpp0079907,modMine:FBpp0079907; MD5=81123010ab0b3de5e540cb6a54645a3c; length=425; release=r6.02; species=Dmel; [fly-2014-05-contam.fasta]
  • type=protein; loc=2L:complement(join(11829176..11829235,11828970..11829103,11828736..11828907,11827460..11828371)); ID=FBpp0079907; name=esc-PA; parent=FBgn0000588,FBtr0080325; dbxref=FlyBase:FBpp0079907,FlyBase_Annotation_IDs:CG14941-PA,GB_protein:AAF53124.1,REFSEQ:NP_477431,GB_protein:AAF53124,FlyMine:FBpp0079907,modMine:FBpp0079907; MD5=81123010ab0b3de5e540cb6a54645a3c; length=425; release=r6.07; species=Dmel; [fly-08202015-contam.fasta]
  • FBpp0079907 type=protein; loc=2L:complement(join(11829176..11829235,11828970..11829103,11828736..11828907,11827460..11828371)); ID=FBpp0079907; name=esc-PA; parent=FBgn0000588,FBtr0080325; dbxref=FlyBase:FBpp0079907,FlyBase_Annotation_IDs:CG14941-PA,GB_protein:AAF53124.1,REFSEQ:NP_477431,GB_protein:AAF53124,FlyMine:FBpp0079907,modMine:FBpp0079907; MD5=81123010ab0b3de5e540cb6a54645a3c; length=425; release=r6.09; species=Dmel; [dmel-all-translation-r6.09.fasta]
  • [fly-122215-dmel-6-09-contam.fasta]
  • type=protein; loc=2L:complement(join(11829176..11829235,11828970..11829103,11828736..11828907,11827460..11828371)); ID=FBpp0079907; name=esc-PA; parent=FBgn0000588,FBtr0080325; dbxref=FlyBase:FBpp0079907,FlyBase_Annotation_IDs:CG14941-PA,GB_protein:AAF53124.1,REFSEQ:NP_477431,GB_protein:AAF53124,UniProt/Swiss-Prot:Q24338,FlyMine:FBpp0079907,modMine:FBpp0079907; MD5=81123010ab0b3de5e540cb6a54645a3c; length=425; release=r6.14; species=Dmel; [fly-dmel-jan2017-sandracontam.fasta]
    • Organism: Drosophila melanogaster
    Length: 425 amino acids

    Gene Ontology:
    Cellular Component: nucleus [IDA]
    nuclear chromatin [ISS]
    ESC/E(Z) complex [IDA]
    Biological Process: gene silencing [IGI][IMP][ISS]
    muscle organ development [IMP]
    histone methylation [IDA]
    chromatin silencing [IPI][ISS][NAS]
    neuron development [IMP]
    dendrite morphogenesis [IMP]
    Molecular Function: DNA binding [ISS]
    protein binding [IPI]
    histone methyltransferase activity (H3-K9 specific) [IC]
    histone methyltransferase activity (H3-K27 specific) [IC]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSSDKVKNGN EPEESEESCG DESASYTTNS TTSRSKSPSS STRSKRRGRR STKSKPKSRA  60
   61 AYKYDTHVKE NHGANIFGVA FNTLLGKDEP QVFATAGSNR VTVYECPRQG GMQLLHCYAD 120
  121 PDPDEVFYTC AWSYDLKTSS PLLAAAGYRG VIRVIDVEQN EAVGNYIGHG QAINELKFHP 180
  181 HKLQLLLSGS KDHAIRLWNI QSHVCIAILG GVEGHRDEVL SIDFNMRGDR IVSSGMDHSL 240
  241 KLWCLNTPEF HHKIELSNTF SQEKSTLPFP TVTKHFPDFS TRDIHRNYVD CVQWFGNFVL 300
  301 SKSCENAIVC WKPGQLHQSF EQVKPSDSSC TIIAEFEYDE CEIWFVRFGF NPWQKVIALG 360
  361 NQQGKVYVWE LDPSDPEGAH MTTLHNSRSV ATVRQIAFSR DASVLVYVCD DATVWRWNRR 420
  421 QTTSI

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    SHOWING SINGLE HITS. [ Hide Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data



    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle