Protein Overview: esc-PA

General Information:
Name(s) found:	esc-PA / FBpp0079907 [FlyBase]
Description(s) found: Found 26 descriptions. SHOW ALL	The gene extra sexcombs is referred to in FlyBase by the symbol Dmel\esc (CG14941, FBgn0000588). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 2L:11827180..11829402. It has the cytological map location 33A2. There is experimental evidence that it has the molecular function</span>: protein binding. There is experimental evidence that it is involved in the biological process</span>: gene silencing; histone methylation; dendrite morphogenesis; neuron development; muscle organ development; chromatin silencing. 55 alleles are reported. The phenotypes of these alleles are annotated with 35 unique terms, many of which group under: embryonic segment; embryonic abdomen; adult segment; embryonic tagma; thoracic segment; abdominal segment 7; embryonic head; peripheral nervous system; embryonic thoracic segment; embryonic abdominal segment 4; abdominal segment 10; antennal segment; midgut constriction. It has one annotated transcript and one annotated polypeptide. [FlyBase]
Organism:	Drosophila melanogaster
Length:	425 amino acids
Gene Ontology:
Cellular Component:	nucleus [IDA] nuclear chromatin [ISS] ESC/E(Z) complex [IDA]
Biological Process:	gene silencing [IGI][IMP][ISS] muscle organ development [IMP] histone methylation [IDA] chromatin silencing [IPI][ISS][NAS] neuron development [IMP] dendrite morphogenesis [IMP]
Molecular Function:	DNA binding [ISS] protein binding [IPI] histone methyltransferase activity (H3-K9 specific) [IC] histone methyltransferase activity (H3-K27 specific) [IC]

Sequence:

Sequence:
[PDR BLAST]
[ProtParam]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSSDKVKNGN EPEESEESCG DESASYTTNS TTSRSKSPSS STRSKRRGRR STKSKPKSRA  60
   61 AYKYDTHVKE NHGANIFGVA FNTLLGKDEP QVFATAGSNR VTVYECPRQG GMQLLHCYAD 120
  121 PDPDEVFYTC AWSYDLKTSS PLLAAAGYRG VIRVIDVEQN EAVGNYIGHG QAINELKFHP 180
  181 HKLQLLLSGS KDHAIRLWNI QSHVCIAILG GVEGHRDEVL SIDFNMRGDR IVSSGMDHSL 240
  241 KLWCLNTPEF HHKIELSNTF SQEKSTLPFP TVTKHFPDFS TRDIHRNYVD CVQWFGNFVL 300
  301 SKSCENAIVC WKPGQLHQSF EQVKPSDSSC TIIAEFEYDE CEIWFVRFGF NPWQKVIALG 360
  361 NQQGKVYVWE LDPSDPEGAH MTTLHNSRSV ATVRQIAFSR DASVLVYVCD DATVWRWNRR 420
  421 QTTSI

Protein Complex Data

No complex found for this protein.

Mass Spectrometry Data

No mass spectrometry results found for this protein.

Yeast Two-Hybrid Data

The following interactions contain this protein:

SHOWING SINGLE HITS. [ Hide Single Hits ]

[View our yeast two-hybrid interpretation guidelines.]

No yeast two-hybrid interactions found for this protein.

Protein predicted to be:	GLOBULAR (No transmembrane regions or signal peptide)
Confidence of classification:	0.99

Protein Overview: esc-PA

Protein Complex Data

Mass Spectrometry Data

Yeast Two-Hybrid Data

Microscopy / Localization Data

Protein Structure Data

Philius Transmembrane Prediction: