Protein Overview: mre11-PA

General Information:
Name(s) found:	mre11-PA / FBpp0079802 [FlyBase]
Description(s) found: Found 24 descriptions. SHOW ALL	The gene meiotic recombination 11 is referred to in FlyBase by the symbol Dmel\mre11 (CG16928, FBgn0020270). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 2L:11282093..11284337. It has the cytological map location 32E2. Based on sequence similarity, it is predicted to have molecular function</span>: endonuclease activity; exonuclease activity. There is experimental evidence that it is involved in the biological process</span>: G2/M transition DNA damage checkpoint; cellular response to DNA damage stimulus; telomere maintenance; chromosome organization; telomere capping. 10 alleles are reported. The phenotype of these alleles is annotated with: chromosome, telomeric region. It has one annotated transcript and one annotated polypeptide. [FlyBase]
Organism:	Drosophila melanogaster
Length:	620 amino acids
Gene Ontology:
Cellular Component:	nucleus [IEA]
Biological Process:	chromosome organization [IMP] nucleotide-excision repair [NAS] telomere maintenance [IMP] G2/M transition DNA damage checkpoint [IMP] telomere capping [IDA] DNA metabolic process [IEA] response to DNA damage stimulus [IMP] double-strand break repair [ISS]
Molecular Function:	exonuclease activity [ISS][NAS] endonuclease activity [ISS][NAS] manganese ion binding [IEA]

Sequence:

Sequence:
[PDR BLAST]
[ProtParam]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MNGTTTAEQD ADNVIRILVA TDNHLGYGEK DAVRGEDSFT AFEEILELAV SEDVDMILLG  60
   61 GDLFHDAVPS QNALHKCIEL LRRYTFGDRP VSLEILSDQG QCFHNAVNQS VNYEDPNLNI 120
  121 AIPVFSIHGN HDDPSGFGRL SSLDLLSTSG LVNYFGRWTD LTQVEISPVL MRKGESQLAL 180
  181 YGLSHIHDGR LARLIKDFKV KFNCPENVAN GEDGNESKEE EDWFHLLVVH QNRADRGPKN 240
  241 YLPEDLLPSF LHLVIWGHEH DCRIEPEENA KKRFYVSQPG SSVPTSLSEG EAKKKHVGLL 300
  301 EIYKGKFKLK PLPLETVRPF VYESVVLADH ADELGLVEGD ASTKVFKFAQ ERVEAMIERA 360
  361 VAQHTGHPKQ PTLPLIRLRL LYTDESCMFN AIRFGEMLST RVANVQDVVQ FSKVVKRTKT 420
  421 EAVNLDKEAL RRALEADNAT RVEELVDRYF EEAKSNKPLK LFHSKALAEM TYRLLEQRDA 480
  481 DAAENIVKFY KEKAVDHLME AMPNDENIDE ELERFRALHK HGDLLKMLDT QGLKVKKEEK 540
  541 SMSVLGSEVN VSTAPATGRG AARGRGTART RAGATAATRG KGQLDVTVSS TRTSGRQQTL 600
  601 LSSLMGSRNT ASYVISDDSD

Protein Complex Data

No complex found for this protein.

Mass Spectrometry Data

No mass spectrometry results found for this protein.

Yeast Two-Hybrid Data

The following interactions contain this protein:

SHOWING SINGLE HITS. [ Hide Single Hits ]

[View our yeast two-hybrid interpretation guidelines.]

No yeast two-hybrid interactions found for this protein.

Protein predicted to be:	GLOBULAR (No transmembrane regions or signal peptide)
Confidence of classification:	0.99

Protein Overview: mre11-PA

Protein Complex Data

Mass Spectrometry Data

Yeast Two-Hybrid Data

Microscopy / Localization Data

Protein Structure Data

Philius Transmembrane Prediction: