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Protein Overview: HP6-PA

General Information:
Name(s) found: HP6-PA / FBpp0077134 [FlyBase]
Description(s) found:
Found 21 descriptions.
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  • The gene Heterochromatin protein 6 is referred to in FlyBase by the symbol Dmel\HP6 (CG15636, FBgn0031613). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 2L:4577719..4578201. It has the cytological map location 25A1. Based on sequence similarity, it is predicted to have molecular function</span>: DNA binding. There is experimental evidence that it is involved in the biological process</span>: female meiosis; telomere capping. 3 alleles are reported. The phenotypes of these alleles are annotated with: larval salivary gland; polar body nucleus; polytene chromosome, telomeric region. It has one annotated transcript and one annotated polypeptide. [FlyBase]
    • Organism: Drosophila melanogaster
    Length: 106 amino acids

    Gene Ontology:
    Cellular Component: polytene chromosome chromocenter [IDA]
    nucleus [IDA][ISS]
    polytene chromosome [IDA]
    polytene chromosome, telomeric region [IDA]
    telomeric heterochromatin [IEP]
    nucleolus [IDA]
    Biological Process: female meiosis [IMP]
    chromatin assembly or disassembly [IEA]
    telomere capping [IMP]
    Molecular Function: DNA binding [ISS]
    chromatin binding [IEA]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MPSSTLTSST ALPVKQRNGF DLGLEPLRIL GACNWSGKLT FLMQWKGCDE AGLVPAEVLN  60
   61 VRCPQMVISF YEERIVFTDE GDEEDLESDN GYETTPSPRK KRSRNA

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..106] PSI-BLAST 33.69897 HP1 chromo shadow domain in complex with PXVXL motif of CAF-1

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • chromatin binding
    		•  3.83416789362162 bayes_pls_golite062009
  • binding
    		•  2.86910316529652 bayes_pls_golite062009
  • transcription regulator activity
    		•  1.83823421170344 bayes_pls_golite062009
  • protein binding
    		•  1.51700626946713 bayes_pls_golite062009
  • histone binding
    		•  1.48525673080866 bayes_pls_golite062009
  • transcription repressor activity
    		•  1.4573414143788 bayes_pls_golite062009
  • DNA-dependent ATPase activity
    		•  0.998957812785999 bayes_pls_golite062009
  • nucleic acid binding
    		•  0.761815318547145 bayes_pls_golite062009
  • DNA helicase activity
    		•  0.726970683178132 bayes_pls_golite062009
  • DNA binding
    		•  0.634713444923942 bayes_pls_golite062009
  • ATP-dependent DNA helicase activity
    		•  0.494788451379878 bayes_pls_golite062009
  • methylated histone residue binding
    		•  0.32228411301259 bayes_pls_golite062009
  • catalytic activity
    		•  0.14067200158938 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.87

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle