YRC Public Data Repository - Protein Structure Prediction

Protein:	HP6-PA
Organism:	Drosophila melanogaster
Length:	106 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for HP6-PA.

Description	E-value	Query Range	Subject Range
gi\|114666540 - gi\|114666540\|ref\|XP_523820.2\| PREDICTED: similar to heterochromatin protein 1 beta [Pan troglodytes]	147.0	[0..11]	[83..272]
gi\|109067205 - gi\|109067205\|ref\|XP_001095397.1\| PREDICTED: similar to chromobox homolog 3 [Macaca mulatta]	143.0	[0..13]	[84..369]
gi\|62858127, gi\|... - gi\|89272794\|emb\|CAJ82321.1\| chromobox homolog 1 (HP1 beta homolog Drosophila ) [Xenopus tropicalis],...	141.0	[0..4]	[90..96]
gi\|76662791 - gi\|76662791\|ref\|XP_870417.1\| PREDICTED: similar to chromobox homolog 3 [Bos taurus]	141.0	[0..14]	[84..31]
gi\|49256331, gi\|... - gi\|49256331\|gb\|AAH74418.1\| MGC84435 protein [Xenopus laevis], gi\|148223529\|ref\|NP_001086279.1\| MGC84...	139.0	[0..4]	[90..96]
gi\|47169035, gi\|... - gi\|47169035\|pdb\|1S4Z\|B Chain B, Hp1 Chromo Shadow Domain In Complex With Pxvxl Motif Of Caf- 1, gi\|4...	139.0	[0..11]	[83..3]
gi\|47213846 - gi\|47213846\|emb\|CAG00650.1\| unnamed protein product [Tetraodon nigroviridis]	139.0	[0..4]	[89..75]
gi\|109488886 - gi\|109488886\|ref\|XP_340886.3\| PREDICTED: similar to Chromobox protein homolog 1 (Heterochromatin pro...	138.0	[0..18]	[83..675]
gi\|50344834, gi\|... - gi\|50344834\|ref\|NP_001002090.1\| chromobox homolog 1b [Danio rerio], gi\|47940432\|gb\|AAH71539.1\| Chrom...	138.0	[0..6]	[90..117]

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Predicted Domain #1

Region A:
Residues: [1-106]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MPSSTLTSST ALPVKQRNGF DLGLEPLRIL GACNWSGKLT FLMQWKGCDE AGLVPAEVLN  60
   61 VRCPQMVISF YEERIVFTDE GDEEDLESDN GYETTPSPRK KRSRNA

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	33.69897
Match:	1s4zA
Description:	HP1 chromo shadow domain in complex with PXVXL motif of CAF-1
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
chromatin binding	3.83416789362162	bayes_pls_golite062009
binding	2.86910316529652	bayes_pls_golite062009
transcription regulator activity	1.83823421170344	bayes_pls_golite062009
protein binding	1.51700626946713	bayes_pls_golite062009
histone binding	1.48525673080866	bayes_pls_golite062009
transcription repressor activity	1.4573414143788	bayes_pls_golite062009
DNA-dependent ATPase activity	0.998957812785999	bayes_pls_golite062009
nucleic acid binding	0.761815318547145	bayes_pls_golite062009
DNA helicase activity	0.726970683178132	bayes_pls_golite062009
DNA binding	0.634713444923942	bayes_pls_golite062009
ATP-dependent DNA helicase activity	0.494788451379878	bayes_pls_golite062009
methylated histone residue binding	0.32228411301259	bayes_pls_golite062009
catalytic activity	0.14067200158938	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: