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Protein Overview: Su(dx)-PB, Su(dx...

General Information:
Name(s) found: FBpp0308612 [FlyBase]
FBpp0306832 [FlyBase]
Su(dx)-PC / FBpp0077497 [FlyBase]
Su(dx)-PA / FBpp0077496 [FlyBase]
Su(dx)-PB / FBpp0077495 [FlyBase]
Description(s) found:
Found 65 descriptions.
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  • type=protein; loc=2L:join(2039992..2040154,2040217..2040359,2040422..2041573,2041647..2042569,2042653..2042851,2042914..2043183); ID=FBpp0308612; name=Su(dx)-PF; parent=FBgn0003557,FBtr0339529; dbxref=FlyBase:FBpp0308612,FlyBase_Annotation_IDs:CG4244-PF,REFSEQ:NP_001259898,GB_protein:AGB92435; MD5=da2af6c478426b1d5220d2121b41684b; length=949; release=r5.56; species=Dmel; [FlyBase]
  • type=protein; loc=2L:join(2039992..2040154,2040217..2040359,2040422..2041573,2041647..2042569,2042653..2042851,2042914..2043183); ID=FBpp0306832; name=Su(dx)-PE; parent=FBgn0003557,FBtr0334778; dbxref=FlyBase:FBpp0306832,FlyBase_Annotation_IDs:CG4244-PE,REFSEQ:NP_001259899,GB_protein:AGB92436; MD5=da2af6c478426b1d5220d2121b41684b; length=949; release=r5.56; species=Dmel; [FlyBase]
  • The gene Suppressor of deltex is referred to in FlyBase by the symbol Dmel\Su(dx) (CG4244, FBgn0003557). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 2L:2037802..2044373. It has the cytological map location 22C1. There is experimental evidence that it has the molecular function</span>: Notch binding. There is experimental evidence that it is involved in the biological process</span>: negative regulation of Notch signaling pathway; receptor internalization; imaginal disc-derived wing margin morphogenesis; imaginal disc-derived wing vein morphogenesis; Notch signaling pathway; imaginal disc-derived leg joint morphogenesis; regulation of protein localization. 12 alleles are reported. The phenotypes of these alleles are annotated with: wing margin; wing vein L3; leg; dorsal mesothoracic disc; crossvein; tarsal segment; wing; wing vein. It has 3 annotated transcripts and 3 annotated polypeptides. [FlyBase]
  • The gene Suppressor of deltex is referred to in FlyBase by the symbol Dmel\Su(dx) (CG4244, FBgn0003557). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 2L:2037802..2044373. It has the cytological map location 22C1. There is experimental evidence that it has the molecular function</span>: Notch binding. There is experimental evidence that it is involved in the biological process</span>: negative regulation of Notch signaling pathway; receptor internalization; imaginal disc-derived wing margin morphogenesis; imaginal disc-derived wing vein morphogenesis; Notch signaling pathway; imaginal disc-derived leg joint morphogenesis; regulation of protein localization. 12 alleles are reported. The phenotypes of these alleles are annotated with: wing margin; wing vein L3; leg; dorsal mesothoracic disc; crossvein; tarsal segment; wing; wing vein. It has 3 annotated transcripts and 3 annotated polypeptides. [FlyBase]
  • The gene Suppressor of deltex is referred to in FlyBase by the symbol Dmel\Su(dx) (CG4244, FBgn0003557). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 2L:2037802..2044373. It has the cytological map location 22C1. There is experimental evidence that it has the molecular function</span>: Notch binding. There is experimental evidence that it is involved in the biological process</span>: negative regulation of Notch signaling pathway; receptor internalization; imaginal disc-derived wing margin morphogenesis; imaginal disc-derived wing vein morphogenesis; Notch signaling pathway; imaginal disc-derived leg joint morphogenesis; regulation of protein localization. 12 alleles are reported. The phenotypes of these alleles are annotated with: wing margin; wing vein L3; leg; dorsal mesothoracic disc; crossvein; tarsal segment; wing; wing vein. It has 3 annotated transcripts and 3 annotated polypeptides. [FlyBase]
    • Organism: Drosophila melanogaster
    Length: 949 amino acids

    Gene Ontology:
    Cellular Component: intracellular [IEA]
    Biological Process: imaginal disc-derived leg joint morphogenesis [IGI]
    Notch signaling pathway [IGI]
    regulation of protein localization [IMP]
    protein modification process [IEA]
    imaginal disc-derived wing margin morphogenesis [IGI]
    imaginal disc-derived wing vein morphogenesis [IGI][IMP]
    negative regulation of Notch signaling pathway [IMP]
    receptor internalization [IMP]
    Molecular Function: ubiquitin-protein ligase activity [ISS][NAS]
    Notch binding [IPI]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MADGNGLPAG AASGGMEAGQ TVNGAGSASP TPTSSSGAGA SGSANQGYHQ LSVTIEEASL  60
   61 RNNGFLKPNP YVELLIDSKS KRKTDLVKNS YLPKWNEEFT VLITPNSTLH FKVLDHSSFR 120
  121 KDAMLGERII NLAHILQHYN GRCEFLELTI DLFVTSKSDN RQTKSGELVA ILNGLKLDMS 180
  181 KLQIQPVAGQ QNGNPPVQAV NPSVVSDAAA GRSCMIYGGV RARMRLRSSS GNSNGGETRS 240
  241 PLPNGGGDHR RSTQAPPVWE QQQQQSQNQQ QPLRMVNGSG AAVPQTAPYP QQPPAPALAR 300
  301 PLTQVYGALP ENTQPAAVYL PAGGGAAVGP PGVAGPPIEQ PGVGLPVSQS TDPQLQTQPA 360
  361 DDEPLPAGWE IRLDQYGRRY YVDHNTRSTY WEKPTPLPPG WEIRKDGRGR VYYVDHNTRK 420
  421 TTWQRPNSER LMHFQHWQGQ RAHVVSQGNQ RYLYSQQQQQ PTAVTAQVTQ DDEDALGPLP 480
  481 DGWEKKIQSD NRVYFVNHKN RTTQWEDPRT QGQEVSLINE GPLPPGWEIR YTAAGERFFV 540
  541 DHNTRRTTFE DPRPGAPKGA KGVYGVPRAY ERSFRWKLSQ FRYLCQSNAL PSHIKITVTR 600
  601 QTLFEDSYHQ IMRLPAYELR RRLYIIFRGE EGLDYGGVSR EWFFLLSHEV LNPMYCLFEY 660
  661 ANKNNYSLQI NPASYVNPDH LQYFKFIGRF IAMALYHGRF IYSGFTMPFY KRMLNKKLTI 720
  721 KDIETIDPEF YNSLIWVKDN NIDECGLELW FSVDFEVLGQ IIHHELKENG EKERVTEENK 780
  781 EEYITLMTEW RMTRGIEQQT KTFLEGFNEV VPLEWLKYFD ERELELILCG MQDVDVEDWQ 840
  841 RNTIYRHYNR NSKQVVWFWQ FVRETDNEKR ARLLQFVTGT CRVPVGGFAE LMGSNGPQRF 900
  901 CIEKVGKETW LPRSHTCFNR LDLPPYKSYD QLVEKLTFAI EETEGFCQE

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data



    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.87

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle