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Protein Overview: RFeSP-PA

General Information:
Name(s) found: RFeSP-PA / FBpp0077580 [FlyBase]
Description(s) found:
Found 15 descriptions.
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  • The gene Rieske iron-sulfur protein is referred to in FlyBase by the symbol Dmel\RFeSP (CG7361, FBgn0021906). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 2L:1612686..1614182. It has the cytological map location 22A3. Based on sequence similarity, it is predicted to have molecular function</span>: ubiquinol-cytochrome-c reductase activity. There is experimental evidence that it is involved in the biological process</span>: lysosome organization. 4 alleles are reported. No phenotypic data is available. It has 2 annotated transcripts and 2 annotated polypeptides. [FlyBase]
    • Organism: Drosophila melanogaster
    Length: 260 amino acids

    Gene Ontology:
    Cellular Component: mitochondrial respiratory chain complex III [ISS]
    Biological Process: lysosome organization [IMP]
    mitochondrial electron transport, ubiquinol to cytochrome c [ISS]
    Molecular Function: ubiquinol-cytochrome-c reductase activity [ISS]
    2 iron, 2 sulfur cluster binding [IEA]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MMNAVSRAYV RGGAQVLSTG LKASGVAVNS MANRQAHTDL QVPDFSAYRR ESVKDSRRRN  60
   61 DTAEERKAFS YLMVGAGAVG GAYAAKGLVN TFIGSMSASA EVLAMAKIEI KLSDIPEGKS 120
  121 VTFKWRGKPL FIRHRTAAEI ETERNVPTST LRDPEADDVG TVEWVDSLML LPISSLATCD 180
  181 QARVAGGHRS VHASGLCAHR ERRRLGWLLL PLPRLPLRRL RKDPQGTRAP QLGGAHPRVP 240
  241 QRGSSRGRLE ELLSFKPPTA

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..260] PSI-BLAST 64.0 ISP subunit of the mitochondrial cytochrome bc1-complex, watersoluble domain; Iron-sulfur subunit (ISP) of cytochrome bc1 complex (Ubiquinol-cytochrome c reductase), transmembrane region

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • ubiquinol-cytochrome-c reductase activity
    		•  12.5243667017255 bayes_pls_golite062009
  • oxidoreductase activity, acting on diphenols and related substances as donors, cytochrome as acceptor
    		•  12.5243667017255 bayes_pls_golite062009
  • oxidoreductase activity, acting on diphenols and related substances as donors
    		•  9.125468664417 bayes_pls_golite062009
  • hydrogen ion transmembrane transporter activity
    		•  6.56410033542443 bayes_pls_golite062009
  • monovalent inorganic cation transmembrane transporter activity
    		•  6.40889163290296 bayes_pls_golite062009
  • oxidoreductase activity
    		•  6.05060612159037 bayes_pls_golite062009
  • inorganic cation transmembrane transporter activity
    		•  5.79350583896014 bayes_pls_golite062009
  • cation transmembrane transporter activity
    		•  5.52425708699797 bayes_pls_golite062009
  • ion transmembrane transporter activity
    		•  5.31511996363681 bayes_pls_golite062009
  • electron carrier activity
    		•  5.20213585732279 bayes_pls_golite062009
  • substrate-specific transmembrane transporter activity
    		•  4.88364619884033 bayes_pls_golite062009
  • substrate-specific transporter activity
    		•  4.66567624087954 bayes_pls_golite062009
  • binding
    		•  1.1265044642485 bayes_pls_golite062009
  • catalytic activity
    		•  0.746741393172769 bayes_pls_golite062009
  • iron-sulfur cluster binding
    		•  0.71220774812099 bayes_pls_golite062009
  • metal cluster binding
    		•  0.71220774812099 bayes_pls_golite062009
  • protein binding
    		•  0.439276074643623 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    [View Details]
    Source: Reynolds et al. 2008. Manuscript submitted Philius confidence legend
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