Protein Overview: lea-PA

General Information:
Name(s) found:	lea-PA / FBpp0077606 [FlyBase]
Description(s) found: Found 20 descriptions. SHOW ALL	The gene leak is referred to in FlyBase by the symbol Dmel\lea (CG5481, FBgn0002543). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 2L:1380086..1420449. It has the cytological map location 22A1. It is reported to have molecular function</span>: axon guidance receptor activity; receptor activity. There is experimental evidence that it is involved in the biological process</span>: salivary gland boundary specification; axon guidance; cardioblast cell fate specification; positive regulation of cell-cell adhesion; mushroom body development; embryonic heart tube development; neuron migration; ventral cord development; central complex development. 35 alleles are reported. The phenotypes of these alleles are annotated with 41 unique terms, many of which group under: organ system; multi-cell-component structure; nervous system; embryonic nervous system; adult segment; peripheral nervous system; embryonic neuron; abdominal transverse muscle; cephalopharyngeal skeleton; commissure. It has one annotated transcript and one annotated polypeptide. [FlyBase]
Organism:	Drosophila melanogaster
Length:	1463 amino acids
Gene Ontology:
Cellular Component:	plasma membrane [NAS]
Biological Process:	ventral cord development [IMP] neuron migration [IMP] mushroom body development [IMP] central complex development [IMP] positive regulation of cell-cell adhesion [IMP] salivary gland boundary specification [IMP] axon guidance [IGI][IMP][TAS] embryonic heart tube development [IMP] cardioblast cell fate specification [IMP] tracheal outgrowth, open tracheal system [TAS]
Molecular Function:	axon guidance receptor activity [NAS] receptor activity [TAS]

Sequence:

Sequence:
[PDR BLAST]
[ProtParam]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MHLCEMRGMP LRLQPQCLTN ESEIQIKIKS KIKNKTASEI KRRHRNNRDF HGERLKIMPV  60
   61 DRSRRAVFPL LLLLAGLNGL TQVGALKGEN PRIIEHPMDT TVPKNDPFTF NCQAEGNPTP 120
  121 TIQWFKDGRE LKTDTGSHRI MLPAGGLFFL KVIHSRRESD AGTYWCEAKN EFGVARSRNA 180
  181 TLQVAFLRDE FRLEPANTRV AQGEVALMEC GAPRGSPEPQ ISWRKNGQTL NLVGNKRIRI 240
  241 VDGGNLAIQE ARQSDDGRYQ CVVKNVVGTR ESATAFLKVH VRPFLIRGPQ NQTAVVGSSV 300
  301 VFQCRIGGDP LPDVLWRRTA SGGNMPLRRV HVLEDRSLKL DDVTLEDMGE YTCEADNAVG 360
  361 GITATGILTV HAPPKFVIRP KNQLVEIGDE VLFECQANGH PRPTLYWSVE GNSSLLLPGY 420
  421 RDGRMEVTLT PEGRSVLSIA RFAREDSGKV VTCNALNAVG SVSSRTVVSV DTQFELPPPI 480
  481 IEQGPVNQTL PVKSIVVLPC RTLGTPVPQV SWYLDGIPID VQEHERRNLS DAGALTISDL 540
  541 QRHEDEGLYT CVASNRNGKS SWSGYLRLDT PTNPNIKFFR APELSTYPGP PGKPQMVEKG 600
  601 ENSVTLSWTR SNKVGGSSLV GYVIEMFGKN ETDGWVAVGT RVQNTTFTQT GLLPGVNYFF 660
  661 LIRAENSHGL SLPSPMSEPI TVGTRYFNSG LDLSEARASL LSGDVVELSN ASVVDSTSMK 720
  721 LTWQIINGKY VEGFYVYARQ LPNPIVNNPA PVTSNTNPLL GSTSTSASAS ASASALISTK 780
  781 PNIAAAGKRD GETNQSGGGA PTPLNTKYRM LTILNGGGAS SCTITGLVQY TLYEFFIVPF 840
  841 YKSVEGKPSN SRIARTLEDV PSEAPYGMEA LLLNSSAVFL KWKAPELKDR HGVLLNYHVI 900
  901 VRGIDTAHNF SRILTNVTID AASPTLVLAN LTEGVMYTVG VAAGNNAGVG PYCVPATLRL 960
  961 DPITKRLDPF INQRYPINQD HVNDVLTQPW FIILLGAILA VLMLSFGAMV FVKRKHMMMK1020
 1021 QSALNTMRGN HTSDVLKMPS LSARNGNGYW LDSSTGGMVW RPSPGGDSLE MQKDHIADYA1080
 1081 PVCGAPGSPA GGGTSSGGSG GAGSGASGGD DIHGGHGSER NQQRYVGEYS NIPTDYAEVS1140
 1141 SFGKAPSEYG RHGNASPAPY ATSSILSPHQ QQQQQQPRYQ QRPVPGYGLQ RPMHPHYQQQ1200
 1201 QHQQQQAQQT HQQHQALQQH QQLPPSNIYQ QMSTTSEIYP TNTGPSRSVY SEQYYYPKDK1260
 1261 QRHIHITENK LSNCHTYEAA PGAKQSSPIS SQFASVRRQQ LPPNCSIGRE SARFKVLNTD1320
 1321 QGKNQQNLLD LDGSSMCYNG LADSGCGGSP SPMAMLMSHE DEHALYHTAD GDLDDMERLY1380
 1381 VKVDEQQPPQ QQQQLIPLVP QHPAEGHLQS WRNQSTRSSR KNGQECIKEP SELIYAPGSV1440
 1441 ASERSLLSNS GSGTSSQPAG HNV

Protein Complex Data

No complex found for this protein.

Mass Spectrometry Data

No mass spectrometry results found for this protein.

Yeast Two-Hybrid Data

The following interactions contain this protein:

NOT SHOWING SINGLE HITS. [ Show Single Hits ]

[View our yeast two-hybrid interpretation guidelines.]

No yeast two-hybrid interactions found for this protein.

Protein Overview: lea-PA

Protein Complex Data

Mass Spectrometry Data

Yeast Two-Hybrid Data

Microscopy / Localization Data

Protein Structure Data

Philius Transmembrane Prediction: